云南某农村高尿酸血症与血脂异常的相关性分析
The Correlation Analysis between Hyperuricemia and Dyslipidemia in Rural Areas, Yunnan Province
-
摘要: 目的 了解云南某农村居民高尿酸血症及血脂异常的患病情况, 分析高尿酸血症与血脂异常及血脂各项指标的关系, 为下一步慢性非传染性疾病的早期预防和营养干预方案设计提供理论依据.方法 采用横断面研究的方法, 选取云南某农村513名18岁以上居民作为研究对象, 抽取调查对象晨空腹静脉血进行血尿酸及血清总胆固醇水平、血清甘油三酯水平 (TG) 及血清高密度脂蛋白胆固醇水平 (HDL-C) 的测定.采用Logistic回归分析高尿酸血症与血脂异常的关系.结果 被调查人群高尿酸血症患病率为18.7%, 高于全国水平, 血脂异常率为44.7%, 高于全国水平;女性高尿酸血症高于男性, 且差别有统计学意义 (P<0.05) ;血脂异常率男性高于女性, 但差别无统计学意义 (P>0.05) .随着年龄的增长高尿酸血症的患病率和血脂异常率呈上升趋势.Logistic回归分析显示:TG、LDL为尿酸的危险因素, 而HDL-C为尿酸的保护因素.结论 定期检测尿酸与血脂水平以及加强农村居民合理膳食等相关宣传教育, 建立健康膳食习惯对于早期预防慢性非传染性疾病具有非常重要的意义.Abstract: Objective To provide evidence-based prevention of chronic disease and nutritional interventions by investigating the development of dyslipidemia and hyperuricemia in rural areas of Yunnan and analyzing the relationship between hyperuricemia and dyslipidemia. Me thods The cross-sectional study recruited 513 residents over 18 years old in 2016. The morning fasting venous blood of all subjects were obtained to detect uric acid, serum total cholesterol (TC) , triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) . Each food factor's blood lipid to the hyperuricemia was determined through multivariate logistic regression. Re s ults The prevalence rates of hyperuricemia and dyslipidemia were 18.7% and 44.7% respectively. Females were more likely to have hyperuricemia than males (P <0.05) . Males were more likely to develop dyslipidemia than females (P >0.05) . The prevalence of hyperuricemia and dyslipidemia increased with age. Logistic regression analysis showed that the level of TG and LDL-C were risk factors and the level of HDL-C was protective factor of hyperuricemia.Conclus ion Regularly testing the levels of uric acid and blood lipid, enhancing the knowledge of reasonable diet and developing healthy dietary habits have significant importance to prevent chronic diseases.
-
Key words:
- Hyperuricemia /
- Dyslipidemia /
- Non-communicable diseases /
- Prevention
-
[1]杨月欣, 张环美.《中国居民膳食指南 (2016) 》简介[J].营养学报, 2016, 38 (3) :209-217. [2]葛均波, 徐永健, 梅长林等.内科学[M].北京:人民卫生出版社, 2013:856. [3]中国成人血脂异常指南修订联合委员会.中国成人血脂异常防治指南2016年修订版[J].中国循环杂志, 2016, 31 (10) :937-950. [4] [4]MAZZA A, LENTI S, SCHIAVON L, et al.Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population[J].Biomed Pharmacother, 2017, 4 (86) :590-594. [5] [5]KUWABARA M.Hyperuricemia, Cardiovascular Disease, and Hypertension[J].Pulse (Basel) , 2015, 3 (3-4) :242-252. [6] [6]ACEVEDO A, BENAVIDES J, CHOWDHURY M, et al.Hyperuricemia and Cardiovascular Disease in Patients with Hypertension[J].Conn Med, 2016, 80 (2) :85-90. [7] [7]YOKOKAWA H, FUKUDA H, SUZUKI A, et al.Association Between Serum Uric Acid Levels/Hyperuricemia and Hypertension Among 85, 286 Japanese Workers[J].J Clin Hypertens (Greenwich) , 2016, 18 (1) :53-59. [8] 国家卫生计生委疾病预防控制局.中国居民营养与慢性病状况报告[M].北京:人民卫生出版社, 2015:1-5. [9]陈涛, 李卫, 王杨等.高尿酸血症的患病情况及相关因素分析[J].中华临床医师杂志, 2012, 6 (13) :3526-3529. [10]强艳, 刘贺荣, 宋辉, 等.宁夏部分人群高尿酸血症的流行特征研究[J].工业卫生与职业病, 2014, 40 (6) :423-432. [11]王珥梅与陆晓荣.常州市成人血尿酸流行病学特征分析[J].职业与健康, 2013, 29 (20) :2675-2676. [12] [12]HAN G M, GONZALEZ S, DEVRIES D.Combined effect of hyperuricemia and overweight/obesity on the prevalence of hypertension among US adults:result from the National Health and Nutrition Examination Survey[J].J Hum Hypertens, 2014, 28 (10) :579-586. [13] [13]ZHANG M, CHANG H, GAO Y et al.Major dietary patterns and risk of asymptomatic hyperuricemia in Chinese adults[J].J Nutr Sci Vitaminol (Tokyo) , 2012, 58 (5) :339-345. [14] [14]FEIG D I.Hyperuricemia and hypertension[J].Adv Chronic Kidney Dis, 2012, 19 (6) :377-385. [15] [15]Whelton A.Hyperuricemia and hypertension:a confluence of concepts[J].Hypertension, 2012, 60 (5) :1112-1113. [16]李迪, 王军波.营养素与人体血尿酸水平关系研究进展[J].中国食物与营养, 2014, 12 (1) :58-62. -
点击查看大图
计量
- 文章访问数: 2598
- HTML全文浏览量: 995
- PDF下载量: 116
- 被引次数: 0
下载:
