白三烯受体拮抗剂联合吸入用激素治疗中重度哮喘的疗效
The Observation of Curative Effect on Leukotriene Receptor Antagonist Combined with Inhaled Hormone in the Treatment of Moderately Severe Asthma
-
摘要: 目的 探讨孟鲁斯特联合吸入用布地奈德混悬液在治疗重度哮喘时的临床疗效.方法 回顾性分析昆明市第二人民医院呼吸内科自2016年1月至2017年8月期间收治的中重度哮喘患者168例, 然后按照数字随机的方法分为对照组和观察组, 对照组患者采取白三烯受体拮抗剂孟鲁斯特进行治疗, 观察组在对照组的基础上加用吸入用布地奈德混悬液进行治疗, 治疗结束时对比2组患者的临床效果、肺功能改善状况以及两组患者治疗前后血气指标.结果 2组患者经治疗期临床症状以及肺功能均有明显的改善, 而观察组患者的改善情况好于对照组患者, 经对比其差异有统计学意义 (P<0.05) .2组患者治疗前后及两组患者治疗后血气分析结果存在差异, 且具有统计学意义 (P<0.05) .结论 在对中重度哮喘进行治疗时采用孟鲁斯特联合吸入用布地奈德混悬液具有良好的临床效果, 能够明显改善患者症状, 可在临床上推广使用.
-
关键词:
- 孟鲁斯特 /
- 吸入用布地奈德混悬液 /
- 中重度哮喘 /
- 临床疗效
Abstract: Objective To explore the clinical efficacy of Montelukast in the treatment of severe asthma.Me thods A retrospective analysis was conducted in the Department of Respiratory Medicine from January 2016 to August 2017.A total of 168 patients with moderately severe asthma were randomly divided into control group and observation group. The control group was treated with leukotriene receptor antagonist Montelukast and the observation group was treated with both Montelukast and budesonide inhalation suspension. Then we compared the clinical effect, lung function and blood gas index before and after treatment between the two groups. Re s ults Significant improvement was observed in the clinical symptoms and lung function in the two groups of patients after the treatment.Compared to the control group, a better improvement was seen in the observation group (P < 0.05) . The results of blood gas analysis were significantly different between the two groups before and after the treatment (P < 0.05) .Conclus ion In the treatment of moderately severe asthma, Montelukast combined with budesonide inhalation suspension has good clinical effect and can significantly alleviate symptoms, which can be widely used clinically. -
[1]蔡勇辉, 卢浩堂, 冯科壬, 等.吸入糖皮质激素联合小剂量茶碱与联合白三烯调节剂治疗5岁以下儿童哮喘的效果比较[J].中国当代医药, 2014, 21 (2) :103-106. [2]区秀燕, 袁小玲, 郭伟洪.布地奈德福莫特罗干粉吸入剂联合孟鲁司特对中重度支气管哮喘肺功能的影响[J].辽宁医学院学报, 2014, 35 (2) :12-14. [3]陈毅斐, 李平, 陈凡, 等.沙美特罗替卡松干粉剂单用和联合孟鲁司特应用对成人中重度哮喘疗效的系统评价[J].中国呼吸与危重监护杂志, 2013, 12 (6) :605-612. [4]吕明明.白三烯受体拮抗剂联合沙美特罗替卡松治疗老年支气管哮喘患者的临床疗效[J].中国药物经济学, 2016, 11 (12) :41-43. [5]刘继东.白三烯受体拮抗剂在缓解期老年支气管哮喘治疗中的临床疗效分析[J].吉林医学, 2013, 34 (25) :5100-5101. [6]李东伟.支气管哮喘临床诊治进展[J].海峡药学, 2016, 28 (5) :155-157. [7]李留栓.儿童中重度哮喘采用白三烯受体拮抗剂孟鲁司特钠治疗的临床疗效观察[J].中国医药指南, 2015, 13 (20) :120-121. [8]龚益, 陈小东.白三烯调节剂在哮喘治疗中的应用[J].上海医药, 2014, 34 (5) :8-12. [9]谢顺英.白三烯受体拮抗剂孟鲁司特钠治疗儿童中重度哮喘的临床疗效[J].临床医学工程, 2012, 19 (10) :1722-1723. [10]池晓群.白三烯受体拮抗剂联合激素治疗小儿中重度哮喘的临床研究[J].吉林医学, 2012, 33 (27) :5873-5874. [11]陈超亮.白三烯受体拮抗剂孟鲁司特钠治疗儿童中重度哮喘的疗效观察[J].中外医疗, 2012, 31 (16) :102-103. [12]鲁萍, 齐志业, 莫亚雄, 等.布地奈德雾化吸入治疗小儿咳嗽变异性哮喘的临床分析[J].昆明医学院学报, 2011, 32 (8) :66-68. [13]范木英, 余泽民, 杜晓华, 等.激发试验的哮喘患者停用舒张剂后阳性率的比较研究[J].昆明医学院学报, 2011, 32 (02) :68-70. [14]张剑青, 赵芝焕, 舒敬奎, 等明.妥洛特罗贴剂治疗轻中度持续支气管哮喘患者的临床疗效观察[J].昆明医学院学报, 2010, 31 (3) :39-50. [15]应红霞.白三烯受体拮抗剂孟鲁司特钠治疗儿童中重度哮喘的疗效观察[J].中国全科医学, 2009, 11 (3) :245-246.
点击查看大图
计量
- 文章访问数: 1401
- HTML全文浏览量: 542
- PDF下载量: 52
- 被引次数: 0