白三烯受体拮抗剂联合吸入用激素治疗中重度哮喘的疗效
The Observation of Curative Effect on Leukotriene Receptor Antagonist Combined with Inhaled Hormone in the Treatment of Moderately Severe Asthma
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摘要: 目的 探讨孟鲁斯特联合吸入用布地奈德混悬液在治疗重度哮喘时的临床疗效.方法 回顾性分析昆明市第二人民医院呼吸内科自2016年1月至2017年8月期间收治的中重度哮喘患者168例, 然后按照数字随机的方法分为对照组和观察组, 对照组患者采取白三烯受体拮抗剂孟鲁斯特进行治疗, 观察组在对照组的基础上加用吸入用布地奈德混悬液进行治疗, 治疗结束时对比2组患者的临床效果、肺功能改善状况以及两组患者治疗前后血气指标.结果 2组患者经治疗期临床症状以及肺功能均有明显的改善, 而观察组患者的改善情况好于对照组患者, 经对比其差异有统计学意义 (P<0.05) .2组患者治疗前后及两组患者治疗后血气分析结果存在差异, 且具有统计学意义 (P<0.05) .结论 在对中重度哮喘进行治疗时采用孟鲁斯特联合吸入用布地奈德混悬液具有良好的临床效果, 能够明显改善患者症状, 可在临床上推广使用.
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关键词:
- 孟鲁斯特 /
- 吸入用布地奈德混悬液 /
- 中重度哮喘 /
- 临床疗效
Abstract: Objective To explore the clinical efficacy of Montelukast in the treatment of severe asthma.Me thods A retrospective analysis was conducted in the Department of Respiratory Medicine from January 2016 to August 2017.A total of 168 patients with moderately severe asthma were randomly divided into control group and observation group. The control group was treated with leukotriene receptor antagonist Montelukast and the observation group was treated with both Montelukast and budesonide inhalation suspension. Then we compared the clinical effect, lung function and blood gas index before and after treatment between the two groups. Re s ults Significant improvement was observed in the clinical symptoms and lung function in the two groups of patients after the treatment.Compared to the control group, a better improvement was seen in the observation group (P < 0.05) . The results of blood gas analysis were significantly different between the two groups before and after the treatment (P < 0.05) .Conclus ion In the treatment of moderately severe asthma, Montelukast combined with budesonide inhalation suspension has good clinical effect and can significantly alleviate symptoms, which can be widely used clinically. -
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