经颅低频聚焦超声联合微泡在开放血脑屏障中的研究进展

张留影; 徐璇; 陈茉弦; 敖丽娟

经颅低频聚焦超声联合微泡在开放血脑屏障中的研究进展

昆明医科大学康复学院

基金项目:

基金：国家自然科学基金资助项目 (81660381);

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出版历程
- 收稿日期: 2018-02-17

Research Progress of Transcranial Focused Ultrasound in Combination with Microbubbles in Treating Open Blood-Brain Barrier

Funds:

基金：国家自然科学基金资助项目 (81660381);

摘要

摘要: 血脑屏障 (blood-brain barrier, BBB) 存在于血液与脑组织之间, 是一种特殊的保护性屏障.BBB的主要功能是选择性阻止大部分血液运载的溶质侵入中枢神经系统 (central nervous system, CNS) , 避免CNS受到损害, 从而有效维持着CNS内环境的稳定和正常的生理功能.但是在某些中枢神经系统疾病中, BBB也阻碍了大部分治疗性药物进入中枢神经系统, 影响了中枢神经系统疾病的有效治疗.因此, 如何安全、可逆地开放BBB成为近年来研究的重点.近年来研究表明, 低频聚焦超声联合微泡 (focused ultrasound-microbubbles therapy, FUS-MB) 能够瞬时、局部和可逆、无创地开放BBB, 开辟了颅内疾病的靶向给药治疗的新途径.对以FUS-MB技术打开BBB的研究进展及其机制予以综述.
- 血脑屏障 /
- 低频聚焦超声 /
- 微泡
Abstract: The blood-brain barrier (BBB) is a special protective barrier existing between the blood and brain tissues. The primary function of BBB is to selectively prevent most solutes in the blood from invading the central nervous system (CNS) and avoid damage to CNS, thereby effectively maintaining the stability and normal physiological function of CNS environment. However, in some CNS diseases, BBB also blocks most therapeutic drugs from entering the central nervous system, which would affect the treatment effect. Therefore, how to open BBB safely and reversibly has become the focus of research in recent years. Recent studies have shown that focused ultrasound-microbubbles therapy (FUS-MB) can open BBB transiently, locally, reversibly and noninvasively, and open up a new approach for targeted therapy of intracranial diseases. This article reviewed relevant research progress and mechanism of BBB opening with FUS-MB technology.
- Blood brain barrier /
- Focused ultrasound /
- Microbubbles

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参考文献(36)

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