经颅低频聚焦超声联合微泡在开放血脑屏障中的研究进展

张留影; 徐璇; 陈茉弦; 敖丽娟

经颅低频聚焦超声联合微泡在开放血脑屏障中的研究进展

昆明医科大学康复学院

基金项目:

基金：国家自然科学基金资助项目 (81660381);

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出版历程
- 收稿日期: 2018-02-17

Research Progress of Transcranial Focused Ultrasound in Combination with Microbubbles in Treating Open Blood-Brain Barrier

Funds:

基金：国家自然科学基金资助项目 (81660381);

摘要

摘要: 血脑屏障 (blood-brain barrier, BBB) 存在于血液与脑组织之间, 是一种特殊的保护性屏障.BBB的主要功能是选择性阻止大部分血液运载的溶质侵入中枢神经系统 (central nervous system, CNS) , 避免CNS受到损害, 从而有效维持着CNS内环境的稳定和正常的生理功能.但是在某些中枢神经系统疾病中, BBB也阻碍了大部分治疗性药物进入中枢神经系统, 影响了中枢神经系统疾病的有效治疗.因此, 如何安全、可逆地开放BBB成为近年来研究的重点.近年来研究表明, 低频聚焦超声联合微泡 (focused ultrasound-microbubbles therapy, FUS-MB) 能够瞬时、局部和可逆、无创地开放BBB, 开辟了颅内疾病的靶向给药治疗的新途径.对以FUS-MB技术打开BBB的研究进展及其机制予以综述.
- 血脑屏障 /
- 低频聚焦超声 /
- 微泡
Abstract: The blood-brain barrier (BBB) is a special protective barrier existing between the blood and brain tissues. The primary function of BBB is to selectively prevent most solutes in the blood from invading the central nervous system (CNS) and avoid damage to CNS, thereby effectively maintaining the stability and normal physiological function of CNS environment. However, in some CNS diseases, BBB also blocks most therapeutic drugs from entering the central nervous system, which would affect the treatment effect. Therefore, how to open BBB safely and reversibly has become the focus of research in recent years. Recent studies have shown that focused ultrasound-microbubbles therapy (FUS-MB) can open BBB transiently, locally, reversibly and noninvasively, and open up a new approach for targeted therapy of intracranial diseases. This article reviewed relevant research progress and mechanism of BBB opening with FUS-MB technology.
- Blood brain barrier /
- Focused ultrasound /
- Microbubbles

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参考文献(36)

[1]	[1]TIMBIE K F, MEAD B P, PRICE R J.Drug and gene delivery across the blood-brain barrier with focused ultrasound[J].Controll Release, 2015, 219 (10) :61-75.
[2]徐兵, 张俞, 杜久林.血脑屏障的研究进展[J].生理学报Acta Physiologica Sinica, 2015, 68 (3) :306-322.
[3]	[3]ZHAO Z, NELSON A R, BETSHOLTZ C, et al.Establishment and dysfunction of the blood-brain barrier[J].Cell, 2015, 163 (5) :1064-1078.
[4]	[4]BAUER H C, KRIZBAI I A, BAUER H, et al.“You Shall Not Pass”-tight junctions of the blood-brainbarrier[J].Front in Neurosci, 2014, 8 (392) :1-21.
[5]	[5]HANSKE S, DYRNA F, BECHMANN I, et al.Different segments of the cerebral vasculature reveal specific endothelial specifications, while tight junction proteins appear equally distributed[J].Brain Struct Funct, 2017, 222 (3) :1179-1192.
[6]	[6]DIAZ R, MIGUEL P M, DENIZ B F, et al.Environmental enrichment attenuates the blood brain barrier dysfunction induced by the neonatal hypoxia-ischemia[J].Int J Dev Neurosci, 2016, 53 (16) :35-45.
[7]	[7]LIAO Z, YANG Z, PIONTEK A, et al.Specific binding of a mutated fragment of Clostridium perfringens enterotoxin to endothelial claudin-5 and its modulation of cerebral vascular permeability[J].Neuroscience, 2016, 327 (16) :53-63.
[8]	[8]BETSHOLTZ C.Physiology:Double function at the blood-brain barrier[J].Nature, 2014, 509 (7501) :432-433.
[9]徐猛, 李延锋, 杨本强, 等.血脑屏障开放及其灌注成像的影响评估[J].中国CT和MRI杂志, 2014, 12 (5) :109-115.
[10]	[10]SHOICHET M S, WINN S R.Cell delivery to the central nervous system[J].Adv Drug Deliv Rev, 2000, 42 (1) :81-102.
[11]	[11]BURGESS A, HYNYNEN K.Noninvasive and targeted drug delivery to the brain using focused ultrasound[J].Acs Cheml Neurosc, 2013, 4 (4) :519-526.
[12]	[12]FAN C H, YEH C K.Microbubble-enhanced focused ultrasound-induced blood-brain barrier opening for local and transient drug delivery in central nervous system disease[J].J Ultras Med, 2014, 22 (4) :183-193.
[13]	[13]MCDANNOLD N, ARYANITIS C D, VYKHODTSEVA N, et al.Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles:safety and efficacy evaluation in rhesus macaques[J].Cancer Res, 2012, 72 (14) :3652-3663.
[14]陈高舒, 郭瑾璇, 杨细飞, 等.低频超声联合微泡治疗阿尔茨海默症的研究进展[J].生物医学工程学进展, 2015, 36 (3) :153-158.
[15]	[15]REBECCA M, NISBET, ANN VAN DER JEUGD, et al.Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse mode[J].Brain 2017, 140 (5) :1220-1230.
[16]	[16]BARNARD J W, FRY W J, FRY F J, et al.Effects of high intensity ultrasound on the central nervous system of the cat[J].The Journal of Comparative Neurology, 1955, 103 (3) :459-484.
[17]	[17]BAKAY L, LEE J C, LEE G C, et al.Experimental cerebral concussion.Part1:an electron microscopic study[J].J Nerosurg, 1977, 47 (4) :525-531.
[18]	[18]HYNYNEN K, MCDANNOLD N, VYKHODTSEVA N, et al.Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits[J].Radiology, 2001, 220 (3) :640-646.
[19]	[19]LAMMERTINK B, DECKERS R, STORM G, et al.Duration of ultrasound-mediated enhanced plasma membrane permeability[J].Int J Pharm, 2015, 482 (1/2) :92-98.
[20]	[20]JORDAO J F, THEVENOT E, MARKHAM-COULTES K, et al.Amyloid-beta plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound[J].Experimental neurology, 2013, 248 (16) :16-29.
[21]	[21] CHEN W S, HSIEH H Y, PITT W G, et al.Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery[J].Journal of Controlled Release, 2015, 212 (19) :1-9.
[22]王敏, 沈圆圆, 汪天富, 等.聚焦超声联合微泡开放血脑屏障机制及监测方法的研究进展[J].2016, 37 (4) :198-203.
[23]	[23]LU M, SHI Y, FANG L, et al.Enhanced-cavitation heating protocols in focused ultrasound surgery with broadband split-focus approach[J].IEEE Tran Ultrason, Ferroelectr Freq Control, 2014, 61 (4) :631-646.
[24]	[24]BAZAN-PEREGRINO M, RIFAI B, CARLISLE R C, et al.Cavitation-enhanced delivery of a replicating oncolytic adenovirus to tumors using focused ultrasound[J].J Control Release, 2013, 169 (1/2) :40-47.
[25]	[25]TAM NHAN, ALISON BURGESS, EUNICE E, et al.Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption:Quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy[J].J Control Release, 2013, 172 (28) :274-280.
[26]罗利红, 吴凤林, 王宝平, 等.超声致微泡声孔效应增强兔VX2肿瘤细胞通透性的适宜声学参数[J].J South Med Univ, 2103, 33 (9) :1377-1381.
[27]	[27]MCDANNOLD N, VYKHODTSEVA N, JOLESZ FA, et al.MRI investigation of the threshold for thermally induced blood-brain disruption and brain tissue danage in the rabbit brain[J].Magn Reson Med, 2004, 51 (5) :913-923.
[28]	[28]ZHOU Q L, CHEN Z Y, WANG Y X.Ultrasound-mediated local drug and gene delivery using nanocarriers[J].Bio Med Research International, 2014, 2014 (10) :963891
[29]	[29]SAMIOTAKI G, KONOFAGOU E E.Dependence of the reversibility of focused-ultrasound-induced blood-brain barrier opening on pressure and pulse length in vivo[J].IEEE Trans Ultrason Ferroelectr Freq Control, 2013, 60 (11) :2257-2265.
[30]	[30]SAMIOTAKI G, VLACHOS F, TUNG Y S, et al.A quantitative pressure and microbubble-size dependence study of focused ultrasound-induced blood-brain barrier opening reversibility in vivo using MRI[J].Magn Reson Med, 2012, 67 (3) :769-777.
[31]	[31]NBURGESS S, HYNYNEN K, Drug delivery across the blood-brain barrier using focused ultrasound, Expert Opin[J].Drug Deliv, 2014, 11 (5) :711-721.
[32]	[32]CHUNG-YIN LIN, HAN-YI HSIEH, WILLIAM G, et al.Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery[J].Journal of Controlled Release, 2015, 212 (10) :1-9.
[33]	[33]CHEN H, KONOFAGOU E E.The size of blood-brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure[J].J Cereb Blood Flow Metab, 2014, 34 (7) :1197-1204.
[34]	[34]LEINENGA G, GOTZ J.Scanning ultrasound removes amyloid-βand restores memory in an Alzheimer’s disease mouse model[J].Sci Transl Med, 2015, 7 (278) :278ra233.
[35]	[35]ARVANITIS C D, LIVINGSTONE M S, VYKHODTSEVA N, et al.Controlled ultrasound-induced blood-brain barrier disruption using passive acoustic emissions monitoring[J].Plos One, 2012, 7 (9) :4578.
[36]	[36]YUEXI HUANG, RYAN ALKINS, MICHAEL L, et al.Opening the blood-brain barrier with MR imaging-guided focused ultrasound:Preclinical testing on a trans-human skull porcine model[J].Radiology, 2017, 282 (1) :123-130.

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