Abstract: Objective To explore the training mode of Bachelor of Medicine and Bachelor of Surgery (MBBS) international students by discussion-based teaching associated with standardized clinical pathway and standardized patients program. Methods This study recruited 60 MBBS international students from 2016 to 2018 and they were randomly divided them into two groups: study group and control group, 30 for each group.Standardized clinical pathway was adopted in medical history-taking and problem-based case discussion mode and diagnosis and examination in English on standardized patients in study group was used while traditional ward round mode was applied in the control group. Effects of teaching were assessed and three capacity modules, medical history-taking, physical examination and case discussion, were evaluated.Results Students had positive responses to the discussion-based teaching associated with standardized clinical pathway and standardized patients program. There were significant differences in three modules between the two groups (P <0.05) .Conclusions Discussion-based teaching associated with standardized clinical pathway and standardized patients program helps to arouse the students' interest, improve self-study ability and cultivate the clinical reasoning ability and is feasible in clinical training and worth promoting.