320排CT评价磨玻璃影相对体积对百草枯所致肺损伤的诊断价值
Diagnostic Value of Relative Volume of Ground Glass Opacities in Lungs Injury by 320-row CT in Paraquat Intoxication
-
摘要: 目的 应用320排CT测定肺部磨玻璃影 (ground glass opacity, GGO) 相对体积评估家兔百草枯中毒后肺损伤程度.方法 48只健康家兔随机分为4组, 以梯度浓度为25、35、45 mg/kg百草枯及等剂量生理盐水灌胃处理, 于中毒后第1、7、14及28 d行320排CT检查, 行GGO相对体积半定量分析, 并于上述时间点每组随机处死1只家兔取肺组织行病理观察.结果 3组实验组与正常对照组比较, GGO相对体积在各时间段均明显大于对照组 (P<0.05) ;3组中毒组家兔之间两两比较, 不同药物浓度作用时存在剂量依赖性 (P<0.05) , 即GGO相对体积随药物剂量增加而增加;光镜下中毒组家兔肺组织表现为不同程度炎性细胞浸润, 局灶性充血, 肺泡间隔增宽, 肺泡萎陷, 部分肺泡腔闭塞, 上述病理改变随时间延长加重.结论 320排CT测定GGO相对体积可以较好量化评价百草枯所致肺损伤, 为临床评价百草枯所致肺损伤提供客观依据.Abstract: Objective To assess the diagnostic value of the relative volume of ground glass opacities (GGO) in lungs injury by 320-row CT in paraquat intoxication.Methods A total of 48 healthy rabbits were randomly divided into four groups: one control group and three experimental groups by gavage treating with the concentration of25, 35, 45 mg/kg paraquat and equal dose of physiological saline.320-row CT examination were performed on the1 st, 7 th, 14 th and 28 th day after poisoning. Semi-quantitative analysis of the relative volume of GGO was conducted. One rabbit from each group were randomly sacrificed to obtain the lung tissue for pathological examinations at each time point.Re s ults Compared with the control group, the relative volumes of GGO in the three experimental groups were significantly greater than that in the control group at each time point (P <0.05) .Significant dose-dependence at different drug concentrationsin in the three experimental groups were found througy multiple comparison (P<0.05) . The relative volume of GGO increased with the increasing of drug dose. The lung tissues of poisoned rabbits under light microscope showed different degrees of inflammatory cell infiltration, focal hyperemia, widened alveolar septum, alveolar collapse, and partial alveolar cavity occlusion, and all the above pathological changes worsened with time.Conclus ion 320 row CT determination of relative volume of GGO can better quantify the paraquat-induced lung injury, which can provide an objective basis for clinical evaluation.
-
Key words:
- 320-row CT /
- Paraquat /
- Lung injury /
- Ground glass opacities /
- Relative volume
-
[1]唐玉珍, 茆金星, 魏继红.血液净化联合免疫抑制治疗百草枯中毒疗效观察与评价[J].中国医药科学, 2014, 4 (1) :59-65. [2] [2]SEOK S J, GIL H W, JEONG D S, et al.Paraquat intoxication in subjects who attempt suicide:why they chose paraquat[J].Korean J Intern Med, 2009, 24 (3) :247-251. [3]李竞, 赵继华, 张泉, 等.高分辨率CT评价磨玻璃密度影对急性百草枯中毒患者的预后价值[J].中华危重病急救医学, 2015, 27 (4) :270-273. [4]刘刚, 宋冬梅, 江宇, 等.血红素氧合酶-1在急性百草枯中毒小鼠肺组织中的表达及意义[J].中华危重病急救医学, 2015, 27 (4) :280-284. [5]唐水英, 叶更新, 刘薇薇, 等.百草枯中毒肺部MSCT表现分析[J].影像诊断与介入放射学, 2016, 25 (2) :147-150. [6]高渝峰, 胡春林, 史晶, 等.兔急性百草枯中毒后血小板内皮细胞黏附分子-1水平对肺损伤的影响[J].中华危重病急救医学, 2011, 23 (10) :585-587. [7]邢鹏毅, 梁家明, 姚斯元, 等.百草枯中毒致肺损伤的64层螺旋CT表现[J].实用医药杂志, 2010, 27 (12) :1072-1073. [8]胡明, 吴伟, 宫建, 等.血必净干预下百草枯中毒大鼠肺组织线粒体融合蛋白2及超微结构变化的研究[J].中华危重病急救医学, 2014, 26 (6) :388-393. [9] [9]POURGHOLAMHOSSEIN F, SHARIFIFAR F, RASOOLI R, et al.Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress[J].Environ Toxicol Pharmacol, 2016, 45 (45) :340-345. [10] [10]SUNTRES Z E.Role of antioxidants in paraquat toxicity[J].Toxicology, 2002, 180 (1) :65-77. [11] [11]ZHANG H, LIU P, QIAO P, et al.CT imaging as a prognostic indicator for patients with pulmonary injury from acute paraquat poisoning[J].Br J Radiol, 2013, 86 (126) :20130035. -
点击查看大图
计量
- 文章访问数: 1944
- HTML全文浏览量: 706
- PDF下载量: 46
- 被引次数: 0
下载:
