Abstract: Objectives To retrospectively analyze the effects of different anesthetic methods on parturient and fetus with cesarean section due to placenta previa and to provide a feasible reference for clinical anesthesia.Me thods From January 2015 to October 2017, 73 cases of parturient undergoing cesarean section due to placenta previa were selected and divided into intraspinal anesthesia group and general anesthesia group. The intraoperative conditions of parturient of the two groups were observed and compared, including the operation time, intraoperative blood loss, infusion volume and application rate of pressor agent, as well as the neonatal conditions, including omphalotomy (I-D) time, umbilical arterial blood p H, PCO2, PO2 and Apgar score 1 min and 5 min after delivery.Re s ults There were 45 cases in general anesthesia group, 28 cases in intraspinal anesthesia group (13 cases with epidural and 15 cases combined with spinal and epidural anesthesia) . Two cases were changed to general anesthesia after intraspinal anesthesia because of incomplete retardation and four cases were also changed to general anesthesia because of large amount of bleeding. There was no significant difference in general conditions between the two groups. The operative time, intraoperative blood loss, application rate of pressor agent and infusion volume in the general anesthesia group were significantly higher than those in the intraspinal anesthesia group (P < 0.05) .There was no significant difference in the omphalotomy (I-D) time, umbilical arterial blood p H, PCO2, PO2 and Apgar score 1 min and 5 min after delivery between the two groups (P>0.05) .Conclus ion For patients with complete placenta previa or large estimated preoperativebleeding volume, it is safer to choose general anesthesia for puerpera and newborns, but for other types of patients, the choosing of anesthesia methods should depend on specific conditions.