Abstract: Objective To explore the application value of enhanced recovery after surgery (ERAS) in the infants with congenital duodenal obstruction. Me thods The clinical data of 71 infants with congenital duodenal obstruction who underwent operation in Kunming Children's Hospital from January 2015 to December 2017 were retrospectively analyzed. The infants were divided, according to the will of their parents, into ERAS group (n=32) and the control group (n=39) , and a new type of perioperative surgical intervention was adopted in ERAS group while traditional perioperative treatment was applied in the control group. First lactation, length of hospital stay, hospital expenses, complications and postoperative body weight growth were observed.Re s ults There was significant difference in the first lactation between the two groups (P<0.05) , (59±12) h and in ERAS group (138±31) h in control group (P<0.05) .The total length of hospital stay and hospital expenses in ERAS group (9.5± 2.5) d and (15.3±2.5) thousand RMB) were significantly lower than those in the control group (16±2.7) d and (19.6±3.1) thousand RMB) (P<0.05) . Follow-up was conducted 8 to 12 weeks after discharge and no significant difference of postoperative complications and postoperative body weight growth of the infants between two groups was found (P > 0.05) , but the body weight of infants in ERAS group increased faster than that in control group.Conclus ion As a safe and feasible approach, ERAS in the infants with congenital duodenal obstruction can shorten the length of hospital stay and reduce hospital expenses and the incidence of complications.