乳腺癌患者放化疗前后维生素D水平的变化

李宁; 徐妙; 张维; 张倩; 孔鹰

乳腺癌患者放化疗前后维生素D水平的变化

西安交通大学第一附属医院肿瘤内科

基金项目:

基金：陕西省自然基础研究计划基金资助项目 (2015JM8427);

计量
- 文章访问数: 2983
- HTML全文浏览量: 1092
- PDF下载量: 75
- 被引次数: 0
出版历程
- 收稿日期: 2018-03-12

Clinical Significance of Serum Vitamin D Levels Change in Patients with Breast Cancer before and after Chemoradiotherapy

Funds:

基金：陕西省自然基础研究计划基金资助项目 (2015JM8427);

摘要

摘要: 目的研究乳腺癌患者放化疗前后维生素D水平变化的临床意义.方法选取2016年6月至2017年6月西安交通大学第一附属医院肿瘤内科收治的乳腺癌患者 (病例组) 和健康女性 (对照组) 各100例, 所有患者术后均接受辅助化疗和放疗, 使用DRG ELISA试剂盒测量血清25-羟基维生素D3 (25-OHD) 水平.结果病例组与对照组在年龄、BMI、分娩次数、血红蛋白水平、总淋巴细胞和血小板计数方面差异无统计学意义 (P>0.05) .病例组维生素D缺乏率为100%, 而对照组中维生素D缺乏率为85%.病例组放化疗前血清维生素D水平为 (16.63±1.83) ng/m L, 对照组为 (25.56±6.64) ng/m L, 病例组放化疗前维生素D水平显著低于对照组 (P<0.001) .病例组化放疗后维生素D平均水平为 (11.35±2.87) ng/m L, 显著低于放化疗前 (P<0.001) .采用2种不同的化疗方案, 分别为FEC/T和CMF方案.放化疗前, 2组患者之间维生素D水平差异无统计学意义 (P>0.05) .放化疗后, 2组患者维生素D水平均显著降低 (P<0.001) , 但2组患者之间维生素D水平差异无统计学意义 (P>0.05) .多重回归分析结果显示, 年龄、BMI、分娩次数与放化疗前后维生素D水平变化显著相关 (P<0.05) , 相关性自大至小依次为年龄、BMI、分娩次数.结论维生素D缺乏症可能与乳腺癌发病有关.患者年龄、BMI、分娩次数均与放化疗前后维生素D水平变化显著相关.
- 乳腺癌 /
- 维生素D /
- 放疗 /
- 化疗
Abstract: Objective To investigate the clinical significance of serum vitamin D levels change in patients with breast cancer (BC) before and after radiotherapy and chemotherapy.Methods A total of 100 BC patients and 100 healthy controls were enrolled in the First Affiliated Hospital of Xi'an Jiaotong University from June 2016 to June 2017. All the patients received adjuvant chemotherapy and radiotherapy after operation. Serum 25-hydroxyvitamin D3 (25-OHD) levels were measured using the DRG ELISA kit.Results There was no significant difference in age, BMI, times of deliveries, hemoglobin level, total lymphocyte count and platelet count between the cases and the controls (P>0.05) . The incidence of vitamin deficiency was 100% in the case group and 85% in the control group. The level of serum vitamin D was (16.63 ± 1.83) ng/ml in the case group before radiotherapy and chemotherapy, and (25.56 ± 6.64) ng/m L in the control group. The level of vitamin D before radiotherapy and chemotherapy in the case group was significantly lower than that of the control group (P< 0.001) . The mean level of vitamin D was (11.35 ± 2.87) ng/m L after radiotherapy and was significantly lower than that before radiotherapy and chemotherapy (P<0.001) . Two different chemotherapy regimens were used in this study, FEC/T and CMF regimens. Before radiotherapy and chemotherapy, there was no significant difference in vitamin D levels between the two groups (P>0.05) . After radiotherapy and chemotherapy, vitamin D levels in both groups were significantly decreased (P<0.001) , but there was no significant difference between the two groups in vitamin D levels (P>0.05) . Multiple regression analysis showed that age, BMI and number of deliveries were significantly correlated with changes of vitamin D levels before and after radiotherapy and chemotherapy (P<0.05) , and correlations were as follows: age, BMI and times of deliveries.Conclusion Vitamin D deficiency may be associated with breast cancer. Patients' age, BMI and times of deliveries were significantly correlated with vitamin D levels before and after radiotherapy and chemotherapy.
- Breast cancer (BC) /
- Vitamin D /
- Radiotherapy /
- Chemotherapy

HTML全文

参考文献(17)

[1]牛四明, 罗欢欢.新辅助化学治疗联合手术治疗局部晚期乳腺癌疗效观察[J].新乡医学院学报, 2017, 34 (5) :429-431.
[2]耿怡, 马富成, 热西达加帕尔, 等.双模态超声在评估乳腺癌新辅助化疗疗效中的应用价值[J].新疆医科大学学报, 2017, 40 (3) :275-278.
[3]	[3]BOEKE C E, TAMIMI R M, BERKEY C S, et al.Adolescent dietary vitamin D and sun exposure in relation to benign breast disease[J].Cancer Causes&Control, 2015, 26 (8) :1-7.
[4]朱玲龑, 冉利梅, 聂四平, 等.677例围绝经期女性维生素D3水平及其影响因素[J].贵州医科大学学报, 2017, 42 (11) :1321-1326.
[5]张莉, 陈健.维生素D缺乏饲料联合高果糖糖水喂养诱导小鼠非酒精性脂肪肝炎[J].兰州大学学报 (医学版) , 2017, 43 (2) :20-27.
[6]	[6]MA Y, YU W D, HERSHBERGER P A, et al.1alpha, 25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model[J].Molecular Cancer Therapeutics, 2008, 7 (9) :3047.
[7]刘刚, 马云婷.乳腺数字化摄影检测在平凉地区触诊阴性乳腺癌诊断中的意义[J].国外医学医学地理分册, 2017, 38 (3) :276-278.
[8]	[8]GIOVANNUCCI E.The epidemiology of vitamin D and cancer incidence and mortality:A review (United States) [J].Cancer Causes&Control Ccc, 2005, 16 (2) :83-95.
[9]NESS R A, MILLER D D, LI W.The role of vitamin D in cancer prevention[J].Chinese Journal of Natural Medicines中国天然药物, 2015, 13 (7) :481-497.
[10]	[10]HOLICK M F, BINKLEY N C, BISCHOFFFERRARI H A, et al.Evaluation, treatment, and prevention of vitamin D deficiency:An Endocrine Society clinical practice guideline[J].Journal of Clinical Endocrinology&Metabolism, 1911, 96 (7) :1911.
[11]蒋安然.绝经前后女性维生素D营养状况及其与血脂代谢相关性研究[D].合肥:安徽医科大学硕士论文, 2015.
[12]	[12]RAGAB W S, SALEH W F, TAWFIK L T.Vitamin D deficiency in postmenopausal Egyptian women[J].International Journal of Gynaecology&Obstetrics the Official Organ of the International Federation of Gynaecology&Obstetrics, 2013, 123 (1) :75-76.
[13]	[13]REZA S F, FAEZEH K.The Correlation of Plasma 25-Hydroxyvitamin D deficiency with risk of breast neoplasms:A systematic review[J].Iranian Journal of Cancer Prevention, 2016, 9 (3) :75-76.
[14]	[14]GHAZI M, ROUX C.Hormonal deprivation therapy-induced osteoporosis in postmenopausal women with breast cancer[J].Best Practice&Research Clinical Rheumatology, 2009, 23 (6) :805-811.
[15]	[15]ABBAS S.Dietary vitamin D and calcium intake and premenopausal breast cancer risk in a German case-control study[J].Nutrition&Cancer, 2007, 59 (1) :54-61.
[16]	[16]LIN J, MANSON J A E, LEE I, et al.Intakes of calcium and vitamin D and breast cancer risk in women[J].Archives of Internal Medicine, 2007, 167 (10) :1050-1059.
[17]	[17]KASSI E N, STAVROPOULOS S, KOKKORIS P, et al.Smoking is a significant determinant of low serum vitamin D in young and middle-aged healthy males[J].Hormones, 2015, 14 (2) :245-250.

相关文章(20)

[1]	刘四香, 黄永坤, 世淑兰, 孙晶晶, 罗丽丝, 王黎, 凌昱. 过敏性紫癜患儿维生素D含量的分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240122
[2]	张楠, 杨彦玲, 万青青, 赵江, 彭敏, 朱晓, 刘志涛, 张强. 云南6个特有少数民族成人维生素D营养状况分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240214
[3]	邹咏艺, 齐志业, 孙冬梅, 万春梅, 梁琨. 不同剂量维生素D对早产儿骨代谢及生长发育影响的队列研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231111
[4]	吴江, 代水芬, 刘琴, 杨寿涛, 张江, 杨娇, 关琼瑶. 鼻咽癌同期放化疗患者实施营养临床护理路径对生活质量的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230510
[5]	徐彤, 马岩团进, 张宇航, 何秋月, 黄薇, 吕梦欣, 唐健, 何建萍, 蒋国庆, 钱源. 不同浓度维生素D 刺激下体外滋养细胞的二代测序研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20221021
[6]	王晨, 李莎, 张博学, 何金花. 补充维生素D对自身免疫性甲状腺炎育龄期女性患者病情的改善作用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220907
[7]	李心怡, 袁勇, 付燕, 朱燕. 不同年龄段妊娠早期妇女维生素D含量水平分布, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220421
[8]	袁勇, 李心怡, 付燕, 朱燕. 昆明地区妊娠期妇女、婴幼儿维生素D水平分析及妊娠期空腹血糖水平与维生素D水平的关联性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220931
[9]	廖佳伟, 胡晓庆, 杨毅. 乳腺癌根治术患者放化疗前后甲状腺功能变化情况及其临床意义, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220229
[10]	吴江, 费严焰, 代水芬, 杨莉, 周倩, 张玲, 石涛. 规范化营养干预对鼻咽癌放疗患者生活质量的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210728
[11]	高燕, 仝向磊, 唐浩然, 武丽. 安宁市婴幼儿及儿童血清脂溶性维生素的水平, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210408
[12]	颜玲玲, 钱志宏, 倪悦, 吴煌. 维生素D及钙补充影响POP人群心脑血管类疾病发生的临床调查, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211036
[13]	张江, 刘燕, 李文辉, 赵喜娟, 陈正庭, 关琼瑶, 吴江. 睡前音乐疗法对乳腺癌放疗患者睡眠质量和癌因性疲乏的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20201248
[14]	李艳红, 张娴, 张俊涛, 赵梦茹, 唐加会, 李琳霞. 昆明市呼吸道感染儿童维生素D营养状况, 昆明医科大学学报.
[15]	李晨, 杨明莹, 段文晶, 蒋爱梅, 黄琪, 杨学芳. 女性乳腺癌患者首次化疗前心理痛苦现状及相关因素, 昆明医科大学学报.
[16]	王怡茗, 杨越. 乳腺钼靶和超声检查对于诊断乳腺癌的价值对比, 昆明医科大学学报.
[17]	卢喜卫. 顺铂联合替莫唑胺及同期放疗治疗术后胶质母细胞瘤, 昆明医科大学学报.
[18]	龙翔宇. 替吉奥联合放疗治疗老年局部晚期食管癌疗效观察, 昆明医科大学学报.
[19]	李晓勇. Th17/Treg平衡失调及其相关因子在乳腺癌浸润转移的相关性研究, 昆明医科大学学报.
[20]	胡礼炳. 云南睾丸生殖细胞肿瘤105例临床特点与疗效评价, 昆明医科大学学报.