苯丙胺类成瘾人群功能影像学检测脑结构与功能变化的研究进展

薛凤麟; 洪仕君; 曾晓锋; 杨荆; 杨根梦; 周一卿; 李利华

苯丙胺类成瘾人群功能影像学检测脑结构与功能变化的研究进展

1. 昆明医科大学法医学院
2. 昆明医科大学第一附属医院病理科

基金项目:

基金：国家自然科学基金资助项目 (81560302);

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出版历程
- 收稿日期: 2018-04-12

Progress of Functional Imaging in Brain Structure and Functional Changes in People with Amphetamine Addiction

Funds:

基金：国家自然科学基金资助项目 (81560302);

摘要

摘要: 苯丙胺类毒品滥用是目前全球最严重的公共卫生问题, 属于慢性复发性脑病.长期滥用苯丙胺类精神兴奋剂会导致特定的脑结构和功能的变化, 而了解成瘾物质的慢性作用时涉及的脑区、神经环路以及生物学基础是明确成瘾行为的确切机制、和寻找有效治疗的根本途径所在.目前国际上应用一系列功能影像学技术, 包括磁共振成像 (magnetic resonance imaging, MRI) , 功能性磁共振成像 (functional magnetic resonance imaging, f MRI) 、磁共振光谱 (magnetic resonance spectroscopy, MRS) 、弥散张量成像 (diffusion tensor imaging, DTI) 和正电子发射断层扫描术 (positron emission tomography, PET) , 观察不同脑区容量/体积的变化情况、脑的血流量变化情况、及脑认知功能异常变化情况.研究结果表明功能影像学技术能够直观反映吸毒人群脑的结构与功能情况, 将有助于阐明苯丙胺类毒品成瘾的确切机制, 为了解此类毒品成瘾的机理提供了新的方法, 特此作一综述.
- 苯丙胺 /
- 成瘾 /
- 功能影像学 /
- 脑结构 /
- 脑功能
Abstract: Amphetamines abuse is defined as a chronic recurrent encephalopathy, and it is a global public health problem which seriously threatens the health of human and the social stability. Long-term abuse and addiction of amphetamines leads to structural and functional changes of specific encephalic regions. Further researches on these encephalic regions, the network of brain and biological information may be helpful to understanding drug abuse mechanism and possible therapeutic measures. Recently, a series of functional imaging techniques, including magnetic resonance imaging (MRI) , functional magnetic resonance imaging (f MRI) , magnetic resonance spectroscopy (MRS) , diffusion tensor imaging (DTI) , and positron emission tomography (PET) , were used to detect different brain structural changes of the volume and density of encephalic regions, functional changes of cerebral blood flow and brain cognition. The results showed functional imaging techniques play significant roles to detect different structural and functional changes of the brain. Based on these results, the researchers aim to clarify the mechanisms of drug abuse. That is the main focus of this review.
- Amphetamines /
- Addiction /
- Functional imaging techniques /
- Structural /
- Functional

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