高尿酸血症的防治策略研究进展

胡欣瑜; 张楠; 董鲜祥; 段为钢; 云宇

高尿酸血症的防治策略研究进展

1. 昆明医科大学基础医学院药理学系
2. 云南中医学院中医药学分子生物学重点实验室

基金项目:

基金：国家自然科学基金资助项目 (81860162); 云南省教育厅科学研究基金资助项目 (2018JS153);

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出版历程
- 收稿日期: 2018-11-19

Update of Treatment for Lowering Serum Urate

Funds:

基金：国家自然科学基金资助项目 (81860162); 云南省教育厅科学研究基金资助项目 (2018JS153);

摘要

摘要: 高尿酸血症是多种疾病的生化基础。降低血尿酸水平可有效防止痛风、肾功能障碍和多种心血管疾病。近年来, 高尿酸血症的防治研究不断取得新成果, 为此, 先简要概述尿酸的来源与去路, 从抑制尿酸合成、促进尿酸排泄和促进尿酸降解方面进行了梳理, 最后提出经肠道局部治疗可能是以后降尿酸的发展方向。
- 高尿酸血症 /
- 黄嘌呤氧化酶抑制剂 /
- 促尿酸排泄药 /
- 碱化尿液 /
- 尿酸酶
Abstract: Hyperuricemia is a foundation of multiple diseases, and lowering serum uric acid is able to effectively prevent and treat the diseases such as gout, renal dysfunction and cardiovascular diseases. Recently, new achievements in study on hyperuricemia treatment and prevention were emerged, which needs to be summed up.At first, the present article briefly reviewed the synthesis and elimination of uric acid, and grouped the ways of prevention and treatment into three strategies: inhibiting synthesis, enhancing excretion, and promoting degradation. In the end, the article put forward that future strategy should focus on intestinal tract to lower serum uric acid by local rather than systematic administration.
- Herperuricemia /
- Xanthine oxidase inhibitor /
- Uricosurics /
- Urine alkalization /
- Urate oxidase

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参考文献(26)

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