可降解镁合金AZ31组织夹在新西兰兔体内的实验研究

孔祥东; 熊希璐; 袁绍峰; 潘良明; 纪亲龙; 王茜

可降解镁合金AZ31组织夹在新西兰兔体内的实验研究

1. 上海市金山区亭林医院外科
2. 上海市金山区金山卫社区卫生服务中心

基金项目:

基金：上海市金山区卫生系统“优秀青年人才“培养计划 (JSYQ201620); 上海市金山区医疗卫生学科建设基金资助项目 (JSZK2015B06);

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出版历程
- 收稿日期: 2018-10-20

Experiment Research of Degradable Magnesium Alloy AZ31 Tissue Clips Implanted to New Zealand Rabbits

Funds:

基金：上海市金山区卫生系统“优秀青年人才“培养计划 (JSYQ201620); 上海市金山区医疗卫生学科建设基金资助项目 (JSZK2015B06);

摘要

摘要: 目的研究镁合金AZ31组织夹在生物体内的降解情况及其对动物各脏器功能的影响。方法建立镁合金AZ31组织夹植入新西兰兔腹腔模型, 定时观察伤口愈合及一般状况。检测血常规、凝血功能、肝肾功能及钙磷镁等, 观察材料植入后上述指标的变化。收集心、肝、脾、肺、肾及脑等组织标本, 行HE染色, 对各脏器进行组织学观察。通过X线摄片观察组织夹在新西兰兔体内的降解情况。结果血液学检测结果显示, 镁合金AZ31组织夹对血常规各项指标、凝血功能、肝肾功能等均无明显影响 (P> 0.05) 。重要内脏器官组织切片HE染色光镜下未见有害物质集聚。X线片显示, 组织夹在新西兰兔体内发生缓慢降解。结论镁合金AZ31是较为安全的医用可降解镁合金材料, 用其制作的组织夹具有一定的临床应用前景。
- 镁合金 /
- 组织夹 /
- 动物实验
Abstract: Objective To study the degradation of magnesium alloy AZ31 tissue clips and its effect on the function of animal organs. Methods New Zealand rabbits were used to build the magnesium alloy AZ31 implanted model. Regular observation of wound healing and general condition was firstly carried out. And then blood was collected to detect the blood routine, coagulation function, liver and kidney functions and the content of calcium, phosphate and magnesium according to the clinical testing methods. The heart, liver, spleen, lung, kidney samples were collected to examine whether pathological changes contained in them. X-ray was carried out to observe the degradation of tissue clips in New Zealand rabbits. Results The biological safety of AZ31 material was confirmed by safety research in vivo. This material had no effect on the results of blood routine index, coagulation function, hepatic function, and renal function cardiac function. No accumulation of harmful substances was observed under the light microscope after HE staining for tissue sections of important internal organs. X-rays showed that there was no significant gas accumulated around the clips and tissue clips degrade slowly in New Zealand rabbitss.Conlusion Magnesium alloy AZ31 is a relatively safe degradable magnesium alloy material, which can be used to make tissue clips, and has a certain clinical application prospect.
- Magnesium alloy /
- Tissue clip /
- Animal experiments

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