根尖牙乳头干细胞成骨分化的研究进展

钱石兵; 史会萍; 李艳秋; 杨镕羽; 段开文

doi:10.12259/j.issn.2095-610X.S20240926

根尖牙乳头干细胞成骨分化的研究进展

doi: 10.12259/j.issn.2095-610X.S20240926

1.
曲靖医学高等专科学校口腔学院，云南曲靖　655100
2.
昆明市延安医院口腔科，云南昆明　650051
3.
大理大学口腔学院，云南大理　671003

基金项目: 国家自然科学基金资助项目（81160135）；云南省生物医药重大科技专项基金（202102AA100007）；云南省教育厅科学研究基金教师类项目（2024J1609）

详细信息

作者简介:
钱石兵（1996～），男，云南曲靖人，医学硕士，助教，主要从事牙周病和口腔黏膜疾病的防治工作

通讯作者:
段开文，E-mail：kwduan@aliyun.com

中图分类号: R78
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- 被引次数: 0
出版历程
- 收稿日期: 2023-12-05
- 网络出版日期: 2024-09-03
- 刊出日期: 2024-09-25

Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells

1.
School of Stomatology，Qujing Medical College，Qujing Yunnan 655100
2.
Dept. of Stomatology，The Affiliated Yan’an Hospital，Kunming Yunnan 650051
3.
School of Stomatology，Dali University，Dali Yunnan 671003，China

摘要

摘要: 根尖牙乳头干细胞（stem cells from apical papilla，SCAP）具有很强的多系分化潜能，其中成骨分化可以应用于骨组织再生，为口腔颌骨缺损治疗提供新思路。成骨分化是个复杂的网络调控过程，诸如各种细胞因子、表观遗传物质、各种信号分子和信号通路等内源性物质均可产生不同程度的影响。这些因素相互作用可以促进SCAP的增殖、迁移和成骨分化，但其在SCAP成骨分化的不同进程中的具体机制和内在联系各不相同。对近年来有关促进SCAP成骨分化的各种因素及其可能的调控机制研究文献进行综述，以期为其进一步的应用研究提供新信息。
- 根尖牙乳头干细胞 /
- 成骨分化 /
- 细胞因子 /
- 表观遗传 /
- 信号通路
Abstract: Stem cells from apical papilla （SCAP） have a strong multi-line differentiation potential, in which osteogenic differentiation can be applied to bone tissue regeneration, providing a new idea for the treatment of oral jaw defects. Osteogenic differentiation is a complex network regulation process, and endogenous substances such as various cytokines, epigenetic material, various signaling molecules and signaling pathways can have different degrees of influence. The interaction of these factors can promote the proliferation, migration and osteogenic differentiation of SCAP, but the specific mechanisms and internal links in different processes of osteogenic differentiation of SCAP are different. In this paper, the factors that promote osteogenic differentiation of SCAP and their possible regulatory mechanisms were reviewed to provide new information for further application research.
- Apical papilla stem cells /
- Osteogenic differentiation /
- Cytokines /
- Epigenetic inheritance /
- Signal path

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参考文献(50)

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根尖牙乳头干细胞成骨分化的研究进展

doi: 10.12259/j.issn.2095-610X.S20240926

作者简介:
钱石兵（1996～），男，云南曲靖人，医学硕士，助教，主要从事牙周病和口腔黏膜疾病的防治工作

通讯作者:
段开文，E-mail：kwduan@aliyun.com

计量

Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells

计量

目录

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[4]	钱石兵, 张凌鹏, 殷凌云, 李昌全, 李虎, 于鸿滨. 不同浓度的牙髓干细胞成骨能力的研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230214
[5]	徐倩, 崔玉梅, 马思明, 林云红, 熊依菁, 宋子珺, 李旭东. miR-148a-3p靶向SMURF2调节牙髓干细胞和口腔上皮细胞共培养体系成骨分化及牙釉质发育的作用机制, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231103
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留言板

根尖牙乳头干细胞成骨分化的研究进展

doi: 10.12259/j.issn.2095-610X.S20240926

作者简介: 钱石兵（1996～），男，云南曲靖人，医学硕士，助教，主要从事牙周病和口腔黏膜疾病的防治工作

通讯作者: 段开文，E-mail：kwduan@aliyun.com

计量

出版历程

Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells

计量

出版历程

目录

作者简介:
钱石兵（1996～），男，云南曲靖人，医学硕士，助教，主要从事牙周病和口腔黏膜疾病的防治工作

通讯作者:
段开文，E-mail：kwduan@aliyun.com