热量限制与间歇性禁食对炎症及代谢疾病的影响

张熙冰; 牛玲; 刘方; 冉江华

热量限制与间歇性禁食对炎症及代谢疾病的影响

张熙冰¹,
牛玲²,
刘方^2, ,,
冉江华^1, ,

1.
昆明医科大学附属甘美医院肝胆胰外科暨昆明市第一人民医院肝胆胰外科
2.
昆明医科大学附属甘美医院内分泌科暨昆明市第一人民医院内分泌科，云南昆明　650000

基金项目: 国家自然科学基金项目（82060127），春城计划高层次人才培养项目（C202214007）

详细信息

作者简介:
张熙冰（1985～），陕西省商洛人，博士研究生，主治医师，主要从事肝胆胰外科及肝移植的研究工作

通讯作者:
刘方，E-mail：liufang@kmmu.edu.cn

冉江华，E-mail：ranjianghua@kmmu.edu.cn

中图分类号: R593；R589
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出版历程
- 收稿日期: 2024-09-22
- 网络出版日期: 2024-12-05

The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases

Xibing Zhang¹,
Ling Niu²,
Fang Liu^{2
, ,},
Jianghua Ran^{1
, ,}

1.
Department of Hepatobiliary and Pancreatic Surgery，The Affiliated Calmette Hospital of Kunming Medical University and The First Hospital of Kunming
2.
Department of Endocrinology，The Affiliated Calmette Hospital of Kunming Medical University and The First Hospital of Kunming，KunmingYunnan 650000，China

More Information

Corresponding author: 冉江华，博士，二级教授，博士生导师，现任昆明市第一人民医院党委副书记、云南省器官移植质量控制中心主任。享受国务院特殊津贴、云南省政府特殊津贴，并荣获云南省中青年学术和技术带头人、云南省有突出贡献优秀专业技术人才、云岭名医、云南省医学领军人才、万人计划名医、春城人才等20余项荣誉称号。学术兼职包括中国研究型医院学会移植医学专业委员会常委、中国医院协会器官获取与分配工作委员会常委、中华医学会器官移植学分会委员、中国医师协会器官移植医师分会委员、中国医师协会肝脏外科分会委员等。主要从事肝胆胰外科及器官移植领域的研究，主持国家自然科学基金及省、市科研项目10余项，获省、市科技奖励33项（其中省级一等奖2项），拥有国家专利5项、软件著作权2项，以第一或通讯作者发表论文100余篇（SCI收录20余篇），主编和参编学术著作14部，参与制定和编写指南、共识13部。

摘要

摘要: 热量限制（Caloric Restriction，CR）和间歇性禁食（Intermittent Fasting，IF）作为2种饮食干预策略，近年来因其在调节炎症和代谢紊乱中的潜在作用受到广泛关注。随着高热量饮食和久坐生活方式的普及，肥胖、2型糖尿病、心血管疾病等代谢性疾病的发病率显著增加，给公共卫生带来了严峻挑战。本综述探讨了CR和IF通过代谢重塑、自噬激活及抑制炎症通路等机制，在减少炎症、改善代谢健康中的作用。特别是在多发性硬化、系统性红斑狼疮等炎症性疾病中，这2种策略表现出显著的干预效果。此外，CR和IF在肥胖、糖尿病及心血管疾病的代谢调节中也有积极作用。尽管它们在临床应用中具有潜力，但长期依从性和安全性仍是推广的关键挑战。未来研究应侧重个性化干预和多治疗手段的联合应用，以进一步验证CR和IF的临床价值。综上所述，CR和IF为慢性疾病管理提供了新的非药物策略，具有重要的应用前景。
- 热量限制 /
- 间歇性禁食 /
- 免疫性疾病 /
- 炎症调节 /
- 代谢疾病
Abstract: Caloric restriction （CR） and intermittent fasting （IF） are two dietary intervention strategies that have garnered increasing attention for their potential role in regulating inflammation and metabolic disorders. With the widespread adoption of high-calorie diets and sedentary lifestyles, the incidence of metabolic diseases such as obesity, type 2 diabetes, and cardiovascular diseases has risen significantly, posing major public health challenges. This review explores how CR and IF impact inflammation reduction and metabolic health improvement through mechanisms such as metabolic reprogramming, autophagy activation, and inhibition of inflammatory pathways. Notably, both strategies have shown promising intervention effects in inflammatory diseases like multiple sclerosis and systemic lupus erythematosus. Additionally, CR and IF demonstrate positive effects in the metabolic regulation of obesity, diabetes, and cardiovascular diseases. Despite their clinical potential, long-term adherence and safety remain key challenges for widespread implementation. Future research should focus on personalized interventions and the integration of multiple therapeutic approaches to further validate the clinical value of CR and IF. In summary, CR and IF offer novel, non-pharmacological strategies for managing chronic diseases, presenting significant potential for future clinical application.
- Caloric Restriction /
- Intermittent Fasting /
- Immune Diseases /
- Inflammatory Regulation /
- Metabolic Diseases

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参考文献(70)

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热量限制与间歇性禁食对炎症及代谢疾病的影响

作者简介:
张熙冰（1985～），陕西省商洛人，博士研究生，主治医师，主要从事肝胆胰外科及肝移植的研究工作

通讯作者:
刘方，E-mail：liufang@kmmu.edu.cn

冉江华，E-mail：ranjianghua@kmmu.edu.cn

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The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases

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热量限制与间歇性禁食对炎症及代谢疾病的影响

作者简介: 张熙冰（1985～），陕西省商洛人，博士研究生，主治医师，主要从事肝胆胰外科及肝移植的研 究工作

通讯作者: 刘方，E-mail：liufang@kmmu.edu.cn 冉江华，E-mail：ranjianghua@kmmu.edu.cn

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出版历程

The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases

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作者简介:
张熙冰（1985～），陕西省商洛人，博士研究生，主治医师，主要从事肝胆胰外科及肝移植的研究工作

通讯作者:
刘方，E-mail：liufang@kmmu.edu.cn

冉江华，E-mail：ranjianghua@kmmu.edu.cn