长链非编码RNA在软骨发育及骨关节炎中作用机制的研究进展

谢飞飞; 辛隐子; 徐敏; 李景涵; 王伟

长链非编码RNA在软骨发育及骨关节炎中作用机制的研究进展

谢飞飞^{1, 2},
辛隐子^{1, 2},
徐敏¹,
李景涵^{1, 2},
王伟^1, ,

1.
昆明医科大学口腔医学院/医院正畸科，云南昆明　650106
2.
云南省口腔医学重点实验室，云南昆明　650106

基金项目: 国家自然科学基金资助项目（82060196）；云南省“兴滇英才支持计划” 资助项目（XDYC-QNRC-2022-0313）；云南省科技厅-昆明医科大学基础研究联合专项资助项目（202401AY070001-332）；昆明医科大学错颌畸形多阶段多学科联合防治科技创新团队（CXTD202213）

详细信息

作者简介:
谢飞飞（1998～），女，云南昆明人，在读硕士研究生，主要从事骨关节炎炎症研究工作

通讯作者:
王伟，E-mail：wangwei8@kmmu.edu.cn

中图分类号: R684.3
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出版历程
- 收稿日期: 2024-05-16

Research Progress on the Mechanisms of Long Non-Coding RNAs in Cartilage Development and Related Diseases　

Feifei XIE^{1, 2},
Yinzi XIN^{1, 2},
Ming XU¹,
Jinghan LI^{1, 2},
Wei WANG^{1
, ,}

1.
Dept. of Orthodontics，Kunming Medical University School and Hospital of Stomatology，Kunming Yunnan 650106
2.
Yunnan Key Laboratory of Stomatology，Kunming Yunnan 650106，China

More Information

Corresponding author: 王伟，博士，主治医师,讲师，硕士研究生导师。担任云南省口腔正畸学专业住院医师规范化培训指导教师，口腔执业医师资格实践技能考试考官；中华口腔医学会第八届、第九届口腔正畸专业委员会青年委员，云南省口腔医学会第三届口腔正畸专业委员会委员兼秘书；世界正畸医师联盟（WFO）会员、国际牙科研究学会（IADR）会员。入选云南省“兴滇英才支持计划”青年人才。获云南省科技进步三等奖1项，授权专利1项。主持包括国家自然科学基金在内的3项国家及省厅级科研项目，第一作者发表SCI论文3篇。

摘要

摘要: 软骨的生长发育及骨关节炎进程十分复杂，同时受到多种生长因子、细胞因子、内外环境等因素影响，并由多条生物信号分子通路交叉调控，因此，其分子作用机制对于软骨发育和骨关节炎的诊治至关重要。长链非编码RNA（Long non-coding RNAs，LncRNAs）是一类转录本长度超过200个核苷酸的非编码RNA，在生物发育、基因表达以及表观遗传中发挥着复杂精确的调控作用，与人类疾病的发生、发展和防治具有密切关系。近年来，许多与软骨生长发育和炎症相关的lncRNAs被相继发现。通过对lncRNAs的分类、功能及其在软骨发育和炎症中的作用进行系统综述，发现多种lncRNAs参与了软骨生长发育和骨关节炎的发生与发展，调控相关lncRNAs的表达可减轻软骨炎症，减缓疾病进展。本文旨在为lncRNAs与软骨生长发育及骨关节炎的基础研究及临床应用提供科学的参考依据。
- 骨关节炎 /
- 长链非编码RNA /
- 基因调控 /
- 软骨生长发育 /
- 软骨疾病
Abstract: The growth and disease progression of cartilage are highly complex, influenced by various growth factors, cytokines, and both internal and external environmental factors. This process is regulated by multiple intersecting biological signaling pathways. Consequently, the study of its molecular mechanisms is crucial for the development and treatment of cartilage-related diseases. Long non-coding RNAs （lncRNAs） are a class of regulatory non-coding RNAs with transcript lengths exceeding 200 nucleotides. They play a complex and precise role in biological development, gene expression and epigenetics, and are closely associated with the onset, progression and prevention of human diseases. In recent years, numerous lncRNAs related to cartilage growth and disease have been discovered. This article systematically reviews the classification, function and mechanisms of action of lncRNAs in cartilage development and disease. It reveals that various lncRNAs are involved in the onset and progression of cartilage growth and diseases. Regulating the expression of relevant lncRNAs can alleviate cartilage inflammation and slow disease progression. This paper aims to provide a scientific basis for basic research and clinical application of lncRNAs in cartilage growth and disease.
- Osteoarthritis /
- Long non-coding RNA /
- Regulation of genes /
- Cartilage growth and development /
- Cartilage diseases

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