Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus
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摘要:
目的 通过评估全身免疫炎症指数（systemic immune inflammatory index，SII）水平与系统性红斑狼疮（systemic lupus erythematosus，SLE）患者的疾病活动度之间的关系，探索SLE患者疾病活动度简便评估的新方法； 方法 收集在昆明医科大学第一附属医院风湿免疫科就诊的SLE患者临床资料，根据系统性红斑狼疮活动指数（SLEDAI）分组，比较、分析SII水平与疾病活动的相关性，绘制接受者工作特征曲线（receiver operating characteristic curve，ROC），评价SII对SLE疾病活动度的预测价值。 结果 SLE患者疾病轻度活动组的SII水平显著低于重度活动组（经Bonferroni校正，P < 0.05/3 = 0.017），SII水平与SLEDAI评分存在相关性（r=0.130， P < 0.05），ROC曲线下面积为0.581（ P < 0.05）。 结论 SII可作为反映 SLE 疾病活动度的一种简便、快速的参考指标。 -
关键词:
- 系统性红斑狼疮 /
- 全身免疫炎症指数 /
- 系统性红斑狼疮活动指数
Abstract:Objective To explore a new method for assessing disease activity in patients with systemic lupus erythematosus （SLE） by evaluating the relationship between the level of the systemic immune-inflammatory index （SII） and disease activity in SLE patients. Methods Clinical data of SLE patients who treated in the Department of Rheumatology and Immunology of First Affiliated Hospital of Kunming Medical University were collected. Patients were grouped based on the Systemic Lupus Erythematosus Disease Activity Index （SLEDAI）. The correlation between SII level and disease activity was compared and analyzed, and Receiver operating characteristic curve （ROC） was plotted to evaluate the predictive value of SII for SLE disease activity. Results The SII levels in the mild active group of SLE patients were significantly lower than that in the severe active group （Bonferroni correction, P < 0.05/3 = 0.017）. There was a correlation between SII levels and SLEDAI scores （r = 0.130, P < 0.05）, with an area under the ROC curve of 0.581 （P < 0.05）. Conclusion SII can serve as a simple and quick reference indicator for reflecting disease activity in SLE. -
图 2 SII预测 SLE 患者病情是否活动的 ROC 曲线
Figure 2. ROC curve for predicting whether SLE patients are in an active disease state based on SII
表 1 按疾病活动度分组SLE患者一般资料和SII值的比较
Table 1. Comparison of general information and SII values among SLE patients grouped by disease activity
项目 SLE疾病活动度分组 $ {\chi }^{2} $/F P 轻度活动组 中度活动组 重度活动组 例数[n（%）] 134（26.74） 166（33.13） 201（40.11） − − 性别（男/女） 11/123 16/150 20/181 0.306 0.858 年龄（岁） 35（25.75，45.00） 34（26.00，47.00） 32（24.00，44.51） 2.731 0.255 WBC（×109/L） 4.96（3.79，6.34） 4.87（3.69，7.39） 4.82（3.17，7.19） 1.088 0.580 N（×109/L） 3.14（2.32，4.23） 3.20（2.22，5.29） 3.46（1.88，5.41） 1.835 0.400 L（×109/L） 1.31（0.91，1.77） 1.10（0.77，1.54） 0.89（0.56，1.32） 37.602 < 0.001* PLT（×109/L） 202.50（149.00，248.00） 182.00（138.25，258.50） 177.00（121.50，226.50） 9.598 0.008* SLEDAI 4.00（2.00，6.00） 10.00（8.00，12.00） 18.00（15.00，22.00） 441.34 < 0.001* SII 468.54（252.48，808.33） 578.11（300.34， 1027.66 ）616.07（326.68， 1203.04 ）9.569 0.008* *P < 0.05。 
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表 2 SII值对SLE疾病活动度的预测价值
Table 2. Predictive value of SII for the disease activity of SLE
指标 Cut-Off 灵敏度（%） 特异性（%） 曲线下
面积95%CI P SII 821.4 38.2 76.00 0.581 0.530～0.632 0.003
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