桥本甲状腺炎与病毒感染之间关系的研究进展

张芳; 高雪娟; 陈玉; 范源; 陈祖琨

doi:10.12259/j.issn.2095-610X.S20201241

桥本甲状腺炎与病毒感染之间关系的研究进展

doi: 10.12259/j.issn.2095-610X.S20201241

张芳¹,
高雪娟²,
陈玉²,
范源^3, ,,
陈祖琨^3, ,

1.
台州市中西医结合医院内分泌科，浙江台州　317523
2.
云南中医药大学临床医学院，云南昆明　650500
3.
云南中医药大学第二附属医院内分泌科/云南省高校中西医结合防治甲状腺疾病重点实验室，云南昆明　650000

基金项目: 国家自然科学基金资助项目（81360652）；云南省应用基础研究计划－中医联合重点基金资助项目（201601ULH00002）

详细信息

作者简介:
张芳（1992～），女，内蒙古自治区鄂尔多斯人，硕士，住院医师，主要从事中西结合防治内分泌代谢疾病诊疗工作

通讯作者:
范源，E-mail： 1647909799@qq.com

陈祖琨，E-mail： 535362396@qq.com

中图分类号: R581
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出版历程
- 收稿日期: 2020-04-26
- 刊出日期: 2019-12-26

Advances on the Association between Hashimoto's Thyroiditis and Viral Infection

Fang ZHANG¹,
Xue-juan GAO²,
Yu CHEN²,
Yuan FAN^{3
, ,},
Zu-kun CHEN^{3
, ,}

1.
Dept.of Endocrinology，Taizhou Integrated Traditional Chinese and Western Medicine Hospital，Taizhou Zhejiang 317523
2.
Clinical Medical College of Yunnan University of Chinese Medicine，Kunming Yunnan 650500
3.
Dept.of Endocrinology，The 2nd Affiliated Hospital of Yunnan University of Chinese Medicine/ Key Laboratory of integrated traditional Chinese and Western medicine in prevention and treatment of thyroid diseases，Kunming Yunnan 650000，China

摘要

摘要: 桥本甲状腺炎（hashimoto thyroiditis，HT）的发病率一直呈上升趋势，中青年女性发病率尤为突出。HT的特征是甲状腺出现大量的淋巴细胞浸润，淋巴滤泡形成、甲状腺滤泡上皮细胞变性，参与此过程的最主要的有Th1型T辅助淋巴细胞、细胞毒性T淋巴细胞、自然杀伤细胞（natural killer cells，NK）、单核细胞、浆细胞。桥本甲状腺炎的发病原因较为复杂，环境因素、遗传因素、免疫紊乱等均与该病的发生有关联。近年来桥本甲状腺炎与病毒感染之间的关系受到研究者们关注，人类细小病毒B19、人疱疹病毒6型（HHV-6）、丙型肝炎（HCV）、EB病毒、单纯疱疹病毒（HSV）、人类获得性免疫缺陷病毒（HIV）等感染可能是桥状腺炎的发病原因之一。现就桥本甲状腺炎发病与病毒感染之间的关系研究进展作综述。
- 桥本甲状腺炎 /
- 病毒感染 /
- 自身免疫性疾病
Abstract: The incidence of Hashimoto Thyroiditis（HT）has been on the rise, especially in young and middle-aged women. Th1 T helper lymphocytes, cytotoxic T lymphocytes, natural killer cells（NK）, monocytes, plasma cells are the most important agents involved in this process. The etiology of Hashimoto thyroiditis is complicated, involving environmental factors, genetic factors and immune disorders, among others. In recent years, the relationship between Hashimoto thyroiditis and viral infection has attracted many researchers. Human parvovirus B19, human herpesvirus 6（HHV-6）, hepatitis C（HCV）, EB virus, herpes simplex virus（HSV）, human acquired immunodeficiency virus（HIV）and other microorganism infections may be the pathogenesis of Hashimoto thyroiditis. This article provides a comprehensive review of relationship between the Hashimoto thyroiditis and viral infection.
- Hashimoto thyroiditis /
- Viral infection /
- Autoimmune diseases

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桥本甲状腺炎与病毒感染之间关系的研究进展

doi: 10.12259/j.issn.2095-610X.S20201241

作者简介:
张芳（1992～），女，内蒙古自治区鄂尔多斯人，硕士，住院医师，主要从事中西结合防治内分泌代谢疾病诊疗工作

通讯作者:
范源，E-mail： 1647909799@qq.com

陈祖琨，E-mail： 535362396@qq.com

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Advances on the Association between Hashimoto's Thyroiditis and Viral Infection

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目录

[1]	赵汉青, 钱石兵, 王孟琪, 杨镕羽, 段开文. 新型冠状病毒感染相关口腔损害, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220831
[2]	王晨, 李莎, 张博学, 何金花. 补充维生素D对自身免疫性甲状腺炎育龄期女性患者病情的改善作用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220907
[3]	阮小荟, 向茜, 王玉明, 周治含, 张弦, 郭燕, 杨晓瑞. 维生素D受体基因Bg1I、Cdx-2位点多态性与桥本氏甲状腺炎的相关性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210824
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桥本甲状腺炎与病毒感染之间关系的研究进展

doi: 10.12259/j.issn.2095-610X.S20201241

作者简介: 张芳（1992～），女，内蒙古自治区鄂尔多斯人，硕士，住院医师，主要从事中西结合防治内分泌代谢疾病诊疗工作

通讯作者: 范源，E-mail： 1647909799@qq.com 陈祖琨，E-mail： 535362396@qq.com

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Advances on the Association between Hashimoto's Thyroiditis and Viral Infection

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作者简介:
张芳（1992～），女，内蒙古自治区鄂尔多斯人，硕士，住院医师，主要从事中西结合防治内分泌代谢疾病诊疗工作

通讯作者:
范源，E-mail： 1647909799@qq.com

陈祖琨，E-mail： 535362396@qq.com