成瘾性物质致肠屏障损伤的研究进展

熊普; 张尊月; 王昆华

doi:10.12259/j.issn.2095-610X.S20210131

成瘾性物质致肠屏障损伤的研究进展

doi: 10.12259/j.issn.2095-610X.S20210131

熊普^{1, 2},
张尊月¹,
王昆华^{1, 2, ,}

1.
国家卫生健康委毒品依赖和戒治重点实验室，昆明医科大学，云南昆明　650500
2.
昆明医科大学第一附属医院胃肠与疝外科，云南昆明　650032

基金项目: 国家自然科学基金资助项目（81860100）

详细信息

作者简介:
熊普（1993～），男，湖北鄂州人，在读硕士研究生，主要从事普通外科、临床营养及肠道微生态研究工作

通讯作者:
王昆华，E-mail：wangkunhua1@163.com，

中图分类号: R74
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- 文章访问数: 2519
- HTML全文浏览量: 1857
- PDF下载量: 45
- 被引次数: 0
出版历程
- 收稿日期: 2020-06-22
- 网络出版日期: 2021-01-26
- 刊出日期: 2021-01-26

Intestinal Barrier Damage Caused by Drug Dependence

Pu XIONG^{1, 2},
Zun-yue ZHANG¹,
Kun-hua WANG^{1, 2
, ,}

1.
NHC Key Laboratory of Drug Addiction Medicine，Kunming Medical University，Kunming Yunnan 650500，China
2.
Dept. of Gastrointestinal and Hernia Surgery，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

摘要

摘要: 药物依赖被认为是严重的慢性复发性脑病，成瘾性物质的长期使用将导致机体出现包括中枢神经系统、呼吸系统、循环系统及消化系统等相关共病的发生和发展。肠屏障因其特殊的解剖位置和生理功能，其在防止“外敌入侵”和维护机体稳态方面发挥重要作用。重点从肠屏障组成和功能、成瘾性物质（苯丙胺类、阿片类、酒精等）致肠屏障损伤研究等方面进行综述，为进一步阐明成瘾性物质致肠屏障损伤机制和后期研究提供理论依据。
- 成瘾性物质 /
- 肠屏障 /
- 损伤 /
- 综述
Abstract: Drug dependence is considered as a serious chronic recurrent encephalopathy. Long-term use of addictive substances will lead to the occurrence and development of related comorbidities including the central nervous system, respiratory system, circulatory system and digestive system. Due to its special anatomical position and physiological function, the intestinal barrier plays an important role in preventing “foreign enemy invasion” and maintaining body homeostasis. This article focuses on the composition and function of the intestinal barrier, and studies on intestinal barrier damage caused by addictive substances （amfetamines, opioids, alcohol, etc.）, and provides theories for further elucidating the mechanism of intestinal barrier damage caused by addictive substances and the later researches.
- Addictive substance /
- Intestinal barrier /
- Injury /
- Review

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参考文献(49)

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成瘾性物质致肠屏障损伤的研究进展

doi: 10.12259/j.issn.2095-610X.S20210131

作者简介:
熊普（1993～），男，湖北鄂州人，在读硕士研究生，主要从事普通外科、临床营养及肠道微生态研究工作

通讯作者:
王昆华，E-mail：wangkunhua1@163.com，

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Intestinal Barrier Damage Caused by Drug Dependence

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目录

[1]	龚学警, 李为明. 紧密连接调节剂Zonulin的研究进展, 昆明医科大学学报.
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[3]	刘路琼, 陈通, 张永进, 谢振荣, 何成禄, 黄永坤. 丁酸对TNFα所致肠上皮屏障损伤的保护作用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231021
[4]	林泽西, 林荔青, 王剑刃, 谢涛, 傅西安, 浦军. 益生菌肠内营养对重型颅脑损伤患者呼吸机相关性肺炎的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211213
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[10]	刘艳. 炎症性肠病与生育, 昆明医科大学学报.
[11]	戴梅. 支气管肺炎患儿的肠粘膜屏障测定及临床意义, 昆明医科大学学报.
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[14]	郭峰. 甲状腺激素对大鼠急性肝衰竭肠粘膜屏障功能影响的实验研究, 昆明医科大学学报.
[15]	葛玉明. 甲状腺激素对大鼠急性肝衰竭肠粘膜屏障功能的保护作用, 昆明医科大学学报.
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留言板

成瘾性物质致肠屏障损伤的研究进展

doi: 10.12259/j.issn.2095-610X.S20210131

作者简介: 熊普（1993～），男，湖北鄂州人，在读硕士研究生，主要从事普通外科、临床营养及肠道微生态研究工作

通讯作者: 王昆华，E-mail：wangkunhua1@163.com，

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出版历程

Intestinal Barrier Damage Caused by Drug Dependence

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出版历程

目录

作者简介:
熊普（1993～），男，湖北鄂州人，在读硕士研究生，主要从事普通外科、临床营养及肠道微生态研究工作

通讯作者:
王昆华，E-mail：wangkunhua1@163.com，