成瘾性物质致肠屏障损伤的研究进展

熊普; 张尊月; 王昆华

doi:10.12259/j.issn.2095-610X.S20210131

成瘾性物质致肠屏障损伤的研究进展

doi: 10.12259/j.issn.2095-610X.S20210131

熊普^{1, 2},
张尊月¹,
王昆华^{1, 2, ,}

1.
国家卫生健康委毒品依赖和戒治重点实验室，昆明医科大学，云南昆明　650500
2.
昆明医科大学第一附属医院胃肠与疝外科，云南昆明　650032

基金项目: 国家自然科学基金资助项目（81860100）

详细信息

作者简介:
熊普（1993～），男，湖北鄂州人，在读硕士研究生，主要从事普通外科、临床营养及肠道微生态研究工作

通讯作者:
王昆华，E-mail：wangkunhua1@163.com，

中图分类号: R74
计量
- 文章访问数: 2508
- HTML全文浏览量: 1854
- PDF下载量: 45
- 被引次数: 0
出版历程
- 收稿日期: 2020-06-22
- 网络出版日期: 2021-01-26
- 刊出日期: 2021-01-26

Intestinal Barrier Damage Caused by Drug Dependence

Pu XIONG^{1, 2},
Zun-yue ZHANG¹,
Kun-hua WANG^{1, 2
, ,}

1.
NHC Key Laboratory of Drug Addiction Medicine，Kunming Medical University，Kunming Yunnan 650500，China
2.
Dept. of Gastrointestinal and Hernia Surgery，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

摘要

摘要: 药物依赖被认为是严重的慢性复发性脑病，成瘾性物质的长期使用将导致机体出现包括中枢神经系统、呼吸系统、循环系统及消化系统等相关共病的发生和发展。肠屏障因其特殊的解剖位置和生理功能，其在防止“外敌入侵”和维护机体稳态方面发挥重要作用。重点从肠屏障组成和功能、成瘾性物质（苯丙胺类、阿片类、酒精等）致肠屏障损伤研究等方面进行综述，为进一步阐明成瘾性物质致肠屏障损伤机制和后期研究提供理论依据。
- 成瘾性物质 /
- 肠屏障 /
- 损伤 /
- 综述
Abstract: Drug dependence is considered as a serious chronic recurrent encephalopathy. Long-term use of addictive substances will lead to the occurrence and development of related comorbidities including the central nervous system, respiratory system, circulatory system and digestive system. Due to its special anatomical position and physiological function, the intestinal barrier plays an important role in preventing “foreign enemy invasion” and maintaining body homeostasis. This article focuses on the composition and function of the intestinal barrier, and studies on intestinal barrier damage caused by addictive substances （amfetamines, opioids, alcohol, etc.）, and provides theories for further elucidating the mechanism of intestinal barrier damage caused by addictive substances and the later researches.
- Addictive substance /
- Intestinal barrier /
- Injury /
- Review

HTML全文

参考文献(49)

[1]	Howell L L,Kimmel H L. Monoamine transporters and psychostimulant addiction[J]. Biochemical pharmacology,2008,75(1):196-217. doi: 10.1016/j.bcp.2007.08.003
[2]	Peterson L W, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis[J]. Nat Rev Immunol,2014,14(3):141-153.
[3]	Kanwal S,Joseph T P,Owusu L,et al. A Polysaccharide isolated from dictyophora indusiata promotes recovery from antibiotic-driven intestinal dysbiosis and improves gut epithelial barrier function in a mouse model[J]. Nutrients,2018,10(8):1003. doi: 10.3390/nu10081003
[4]	Kamada N,Chen G Y,Inohara N,et al. Control of pathogens and pathobionts by the gut microbiota[J]. Nature immunology,2013,14(7):685-690. doi: 10.1038/ni.2608
[5]	Caruso R,Lo B C,Núñez G. Host-microbiota interactions in inflammatory bowel disease[J]. Nat Rev Immunol,2020,20(7):411-426. doi: 10.1038/s41577-019-0268-7
[6]	Salvo Romero E,Alonso Cotoner C,Pardo Camacho C,et al. The intestinal barrier function and its involvement in digestive disease[J]. Rev Esp Enferm Dig,2015,107(11):686-696.
[7]	Giepmans B N,van Ijzendoorn S C. Epithelial cell-cell junctions and plasma membrane domains[J]. Biochim Biophys Acta,2009,1788(4):820-831. doi: 10.1016/j.bbamem.2008.07.015
[8]	Dokladny K,Zuhl M N,Moseley P L. Intestinal epithelial barrier function and tight junction proteins with heat and exercise[J]. J Appl Physiol (1985),2016,120(6):692-701. doi: 10.1152/japplphysiol.00536.2015
[9]	Pott J,Hornef M. Innate immune signalling at the intestinal epithelium in homeostasis and disease[J]. EMBO Reports,2012,13(8):684-698. doi: 10.1038/embor.2012.96
[10]	Nishida A,Inoue R,Inatomi O,et al. Gut microbiota in the pathogenesis of inflammatory bowel disease[J]. Clinical Journal of Gastroenterology,2018,11(1):1-10. doi: 10.1007/s12328-017-0813-5
[11]	Yu M,Wang Q,Ma Y,et al. Aryl Hydrocarbon receptor activation modulates intestinal epithelial barrier function by maintaining tight junction integrity[J]. International Journal of Biological Sciences,2018,14(1):69-77.
[12]	Foti F,Marti M,Ossato A,et al. Phenotypic effects of chronic and acute use of methiopropamine in a mouse model[J]. International Journal of Legal Medicine,2019,133(3):811-820.
[13]	Anderson J E,Brown I E,Olson K A,et al. Nonocclusive mesenteric ischemia in patients with methamphetamine use[J]. The Journal of Trauma Acute Care Surgery,2018,84(6):885-892.
[14]	Hána L,Ryska M. Acute abdomen in drug abusers[J]. Rozhl Chir,2019,98(1):14-17.
[15]	Panikkath R,Panikkath D. Amphetamine-related ischemic colitis causing gastrointestinal bleeding[J]. Proceedings,2016,29(3):325-326.
[16]	Attaran H. Fatal small intestinal ischemia due to methamphetamine intoxication:Report of a case with autopsy results[J]. Acta medica Iranica,2017,55(5):344-347.
[17]	罗华友,陈剑珩,陈凤容,等. 恒河猴甲基苯丙胺依赖肠屏障损伤动物模型的建立[J].中华实验外科杂志,2018,35(3):567-569. doi: 10.3760/cma.j.issn.1001-9030.2018.03.052
[18]	丁凯,虞文魁,冯涛,等. 迷走神经刺激对腹部创伤大鼠肠黏膜屏障的影响研究[J].医学研究生学报,2015,28(3):249-254. doi: 10.3969/j.issn.1008-8199.2015.03.007
[19]	Persons A L,Bradaric B D,Dodiya H B,et al. Colon dysregulation in methamphetamine self-administering HIV-1 transgenic rats[J]. PloS One,2018,13(1):e0190078.
[20]	Peerzada H,Gandhi J A,Guimaraes A J,et al. Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues[J]. Immunobiology,2013,218(8):1063-1068.
[21]	Xue L,Li X,Ren H X,et al. The dopamine D3 receptor regulates the effects of methamphetamine on LPS-induced cytokine production in murine mast cells[J]. Immunobiology,2015,220(6):744-752.
[22]	Reynolds J L,Mahajan S D,Aalinkeel R,et al. Modulation of the proteome of peripheral blood mononuclear cells from HIV-1-infected patients by drugs of abuse[J]. Journal of Clinical Immunology,2009,29(5):646-656.
[23]	Taketomi Y,Murakami M. Immunological regulation by bioactive lipids[J]. Yakugaku Zasshi,2017,137(5):503-515.
[24]	Xue L,Geng Y,Li M,et al. Inhibitory effects of methamphetamine on mast cell activation and cytokine/chemokine production stimulated by lipopolysaccharide in C57BL/6J mice[J]. Experimental Therapeutic Medicine,2018,15(4):3544-3550.
[25]	Angoa-Pérez M,Zagorac B,Winters A D,et al. Differential effects of synthetic psychoactive cathinones and amphetamine stimulants on the gut microbiome in mice[J]. PloS One,2020,15(1):e0227774.
[26]	Bhattarai Y,Schmidt B A,Linden D R,et al. Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT₃ receptor expression via acetate production[J]. Am J Physiol Gastrointest Liver Physiol,2017,313(1):G80-G87.
[27]	Del Vecchio G,Spahn V,Stein C. Novel opioid analgesics and side effects[J]. ACS Chemical Neuroscience,2017,8(8):1638-1640.
[28]	Saccani F,Anselmi L,Jaramillo I,et al. Protective role of μ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice[J]. Journal of Neuroscience Research,2012,90(11):2146-2153. doi: 10.1002/jnr.23108
[29]	Mori T,Shibasaki Y,Matsumoto K,et al. Mechanisms that underlie μ-opioid receptor agonist-induced constipation:differential involvement of μ-opioid receptor sites and responsible regions[J]. J Pharmacol Exp Ther,2013,347(1):91-99.
[30]	Wu J,Liu B,Tong W,et al. Opioid receptors and associated regulator of G protein signaling are involved in the cathartic colon of rats[J]. Experimental Therapeutic Medicine,2015,9(4):1229-1234. doi: 10.3892/etm.2015.2233
[31]	Bian X,Zhou R,Yang Y,et al. Divergent effect of dezocine,morphine and sufentanil on intestinal motor function in rats[J]. International Journal of Medical Sciences,2015,12(11):848-852. doi: 10.7150/ijms.12616
[32]	Pol O,Palacio J R,Puig M M. The expression of delta- and kappa-opioid receptor is enhanced during intestinal inflammation in mice[J]. The Journal of Pharmacology Experimental Therapeutics,2003,306(2):455-462.
[33]	Xiao W,Wang W,Chen W,et al. GDNF is involved in the barrier-inducing effect of enteric glial cells on intestinal epithelial cells under acute ischemia reperfusion stimulation[J]. Mol Neurobiol,2014,50(2):274-289.
[34]	Moretti M,Belli G,Morini L,et al. Drug abuse-related neuroinflammation in human postmortem brains:An immunohistochemical approach[J]. Journal of Neuropathology Experimental Neurology,2019,78(11):1059-1065. doi: 10.1093/jnen/nlz084
[35]	Sharma U,Olson RK,Erhart FN,et al. Prescription opioid induce gut dysbiosis and exacerbate colitis in a murine model of Inflammatory Bowel Disease[J]. Journal of Crohn's Colitis,2019,14(6):801-817.
[36]	Frenklakh L,Bhat RS,Bhaskaran M,et al. Morphine-induced degradation of the host defense barrier role of intestinal mucosal injury[J]. Digestive Diseases Sciences,2006,51(2):318-325. doi: 10.1007/s10620-006-3132-0
[37]	Franchi S,Moretti S,Castelli M,et al. Mu opioid receptor activation modulates toll like receptor 4 in murine macrophages[J]. Brain Behav Immun,2012,26(3):480-488. doi: 10.1016/j.bbi.2011.12.010
[38]	Goldsmith J R,Uronis J M,Jobin C. Mu opioid signaling protects against acute murine intestinal injury in a manner involving Stat3 signaling[J]. The American Journal of Pathology,2011,179(2):673-683. doi: 10.1016/j.ajpath.2011.04.032
[39]	Banerjee S,Sindberg G,Wang F,et al. Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation[J]. Mucosal Immunology,2016,9(6):1418-1428. doi: 10.1038/mi.2016.9
[40]	Wang XP,Lei F,Du F,et al. Protection of gastrointestinal mucosa from acute heavy alcohol consumption:The effect of berberine and its correlation with TLR2,4/IL1β-TNFα signaling[J]. PloS One,2015,10(7):e0134044. doi: 10.1371/journal.pone.0134044
[41]	Cho Y E,Yu L R,Abdelmegeed M A,et al. Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury[J]. Journal of Hepatology,2018,69(1):142-153. doi: 10.1016/j.jhep.2018.02.005
[42]	Barr T,Sureshchandra S,Ruegger P,et al. Concurrent gut transcriptome and microbiota profiling following chronic ethanol consumption in nonhuman primates[J]. Gut Microbes,2018,9(4):338-356.
[43]	Shao T,Zhao C,Li F,et al. Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction[J]. Journal of Hepatology,2018,69(4):886-895. doi: 10.1016/j.jhep.2018.05.021
[44]	Engen P A,Green S J,Voigt R M,et al. The gastrointestinal microbiome:Alcohol effects on the composition of intestinal microbiota[J]. Alcohol Research :Current Reviews,2015,37(2):223-236.
[45]	Leclercq S,de Timary P,Delzenne N M,et al. The link between inflammation,bugs,the intestine and the brain in alcohol dependence[J]. Translational Psychiatry,2017,7(2):e1048. doi: 10.1038/tp.2017.15
[46]	Lu R,Voigt R M,Zhang Y,et al. Alcohol injury damages intestinal stem cells[J]. Alcoholism,Clinical. Experimental Research,2017,41(4):727-734.
[47]	Veazey R S,Amedee A,Wang X,et al. Chronic binge alcohol administration increases intestinal T-cell proliferation and turnover in rhesus macaques[J]. Alcoholism,Clinical. Experimental Research,2015,39(8):1373-1379. doi: 10.1111/acer.12784
[48]	Antón M,Rodríguez-González A,Ballesta A,et al. Alcohol binge disrupts the rat intestinal barrier:the partial protective role of oleoylethanolamide[J]. British Journal of Pharmacology,2018,175(24):4464-4479. doi: 10.1111/bph.14501
[49]	Goldsmith J R,Perez-Chanona E,Yadav P N,et al. Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling[J]. The American Journal of Pathology,2013,182(3):776-785. doi: 10.1016/j.ajpath.2012.11.021

计量

文章访问数: 2508
HTML全文浏览量: 1854
PDF下载量: 45
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

留言板

成瘾性物质致肠屏障损伤的研究进展

doi: 10.12259/j.issn.2095-610X.S20210131

作者简介:
熊普（1993～），男，湖北鄂州人，在读硕士研究生，主要从事普通外科、临床营养及肠道微生态研究工作

通讯作者:
王昆华，E-mail：wangkunhua1@163.com，

计量

Intestinal Barrier Damage Caused by Drug Dependence

计量

目录

[1]	龚学警, 李为明. 紧密连接调节剂Zonulin的研究进展, 昆明医科大学学报.
[2]	李远森, 陈铖, 田衍, 舒若, 徐玉, 李媛华. 海洛因成瘾者不同戒断时间肠道屏障损伤血清标志物的研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230709
[3]	刘路琼, 陈通, 张永进, 谢振荣, 何成禄, 黄永坤. 丁酸对TNFα所致肠上皮屏障损伤的保护作用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231021
[4]	林泽西, 林荔青, 王剑刃, 谢涛, 傅西安, 浦军. 益生菌肠内营养对重型颅脑损伤患者呼吸机相关性肺炎的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211213
[5]	唐杰, 崔婷婷, 徐丹. 光线性角化病危险因素研究进展, 昆明医科大学学报.
[6]	闫慧玲, 赵宏斌, 钱传云, 王应忠, 张洋, 沈相霖, 蒋罡, 高爽. 膝骨关节炎疗效评估的研究进展, 昆明医科大学学报.
[7]	边绍清, 马信文, 王加干, 王勇, 游荔, 贾璞. 骶髂关节复合体损伤的内固定治疗临床效果分析, 昆明医科大学学报.
[8]	杨佳儒. CRISPR-Cas9的原理及其应用进展, 昆明医科大学学报.
[9]	黄万麒. 交通事故中机械性损伤与自身疾病关系的法医学鉴定1例报道, 昆明医科大学学报.
[10]	刘艳. 炎症性肠病与生育, 昆明医科大学学报.
[11]	戴梅. 支气管肺炎患儿的肠粘膜屏障测定及临床意义, 昆明医科大学学报.
[12]	吴丽珍. 急性低温暴露对家兔心肝肾功能的影响, 昆明医科大学学报.
[13]	覃云凌. 阴茎闭合性损伤32例临床分析, 昆明医科大学学报.
[14]	郭峰. 甲状腺激素对大鼠急性肝衰竭肠粘膜屏障功能影响的实验研究, 昆明医科大学学报.
[15]	葛玉明. 甲状腺激素对大鼠急性肝衰竭肠粘膜屏障功能的保护作用, 昆明医科大学学报.
[16]	谢筱晞. 3.0T磁共振成像评价踝关节运动损伤的应用价值, 昆明医科大学学报.
[17]	. 超声介入行损伤控制性手术在胆道损伤中的临床分析, 昆明医科大学学报.
[18]	. 多部位损伤合并结肠损伤16例临床救治体会, 昆明医科大学学报.
[19]	. 高频超声在上肢外周神经损伤性疾病的应用价值, 昆明医科大学学报.
[20]	张扬. 视神经挫伤失明后复明的综合治疗3例, 昆明医科大学学报.

留言板

成瘾性物质致肠屏障损伤的研究进展

doi: 10.12259/j.issn.2095-610X.S20210131

作者简介: 熊普（1993～），男，湖北鄂州人，在读硕士研究生，主要从事普通外科、临床营养及肠道微生态研究工作

通讯作者: 王昆华，E-mail：wangkunhua1@163.com，

计量

出版历程

Intestinal Barrier Damage Caused by Drug Dependence

计量

出版历程

目录

作者简介:
熊普（1993～），男，湖北鄂州人，在读硕士研究生，主要从事普通外科、临床营养及肠道微生态研究工作

通讯作者:
王昆华，E-mail：wangkunhua1@163.com，