大麻二酚在医学上的应用前景

蒋鸿雁; 张瑞林; 曹艳; 吴海鹰; 李坪

doi:10.12259/j.issn.2095-610X.S20210208

大麻二酚在医学上的应用前景

doi: 10.12259/j.issn.2095-610X.S20210208

蒋鸿雁^{1, 4},
张瑞林²,
曹艳¹,
吴海鹰³,
李坪^1, ,

1.
昆明医科大学人体解剖学与组织胚胎学系
2.
法医学院毒物化学系，云南昆明　650500
3.
昆明医科大学第一附属医院急诊医学部，云南昆明　650032
4.
遂宁市中心医院病理科，四川遂宁　629000

基金项目: 国家自然科学基金资助项目（82060241，82002002，81960817）；云南省科技创新团队基金资助项目（2019HC014）

详细信息

作者简介:
蒋鸿雁（1993～），女，四川遂宁人，在读硕士研究生，主要从事人体解剖学与组织胚胎学研究工作

通讯作者:
李坪，E-mail：kyzplp@163.com

中图分类号: R93
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- 文章访问数: 2243
- HTML全文浏览量: 2178
- PDF下载量: 25
- 被引次数: 0
出版历程
- 收稿日期: 2020-11-14
- 刊出日期: 2021-03-05

Application Prospect of Mannabidiol in Medicine

1.
Dept. of Human Anatomy and Histology and Embryology，Kunming Medical University
2.
Dept. of Toxicology，School of Forensic Medicine
3.
Dept. of Emergency Medicine，First Affiliated Hospital，Kunming Yunnan 650032
4.
Dept. of Pathology，Suining Central Hospital，Suining Sichuan，China

摘要

摘要: 大麻中具有药用价值的主要成分是Δ9-四氢大麻酚（Δ9-THC）和大麻二酚（CBD），其中CBD因不能直接激活大麻素1型受体（CB1R）和大麻素2型受体（CB2R）而不具有精神活性和药物依赖性，安全性相对高。CBD作为主要的大麻素提取物，证实具有镇痛、镇静、抗炎、抗惊厥、改善睡眠、抗焦虑、抗精神病、抗风湿、保护皮肤屏障、抗细胞凋亡和神经保护等作用。本综述旨在总结CBD在临床疾病治疗中的应用现状，为今后CBD相关药物在治疗癫痫、神经病理性疼痛、焦虑症和抑郁症、肿瘤、皮肤、代谢相关疾病的应用提供新思路。
- 大麻二酚 /
- 临床应用 /
- 神经保护作用
Abstract: The main components of cannabis with medicinal value are Δ9-tetrahydrocannabinol（Δ9-THC）and cannabidiol（CBD）, of which CBD cannot directly activate cannabinoid type 1 receptor（CB1R）and cannabinoid type 2 receptors. Body（CB2R）does not have psychoactive and drug dependence, and its safety is relatively high. CBD, as the main cannabinoid extract, has proven to have analgesic, sedative, anti-inflammatory, anti-convulsant, sleep-improving, anti-anxiety, anti-psychotic, anti-rheumatic, skin barrier, anti-apoptotic and neuroprotective effects. This review aims to summarize the application status of CBD in the treatment of clinical diseases, and provide new ideas for the future application of CBD-related drugs in the treatment of epilepsy, neuropathic pain, anxiety and depression, tumors, skin, and metabolism-related diseases.
- Cannabidiol /
- Clinical application /
- Neuroprotection

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参考文献(49)

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大麻二酚在医学上的应用前景

doi: 10.12259/j.issn.2095-610X.S20210208

作者简介:
蒋鸿雁（1993～），女，四川遂宁人，在读硕士研究生，主要从事人体解剖学与组织胚胎学研究工作

通讯作者:
李坪，E-mail：kyzplp@163.com

计量

Application Prospect of Mannabidiol in Medicine

计量

目录

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[2]	寸睿, 陈美玲. 氟桂利嗪联合银杏达莫治疗老年眩晕的疗效及临床应用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220703
[3]	杨淑迪, 钟雨莉, 刘玲, 田新. 加速康复外科在新生儿围手术期管理中的应用与展望, 昆明医科大学学报.
[4]	孙孔春, 陈兴龙, 杨璨瑜, 于浩飞, 胡炜彦, 王蕊, 沈报春, 张荣平. 不同条件下工业大麻中大麻二酚含量变化, 昆明医科大学学报.
[5]	宁金梅, 钮燕, 赵树波, 朱媛, 朱恒杰, 汤勇. 外伤性鼓膜穿孔贴补治疗的对比, 昆明医科大学学报.
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大麻二酚在医学上的应用前景

doi: 10.12259/j.issn.2095-610X.S20210208

作者简介: 蒋鸿雁（1993～），女，四川遂宁人，在读硕士研究生，主要从事人体解剖学与组织胚胎学研究工作

通讯作者: 李坪，E-mail：kyzplp@163.com

计量

出版历程

Application Prospect of Mannabidiol in Medicine

计量

出版历程

目录

作者简介:
蒋鸿雁（1993～），女，四川遂宁人，在读硕士研究生，主要从事人体解剖学与组织胚胎学研究工作

通讯作者:
李坪，E-mail：kyzplp@163.com