甲基苯丙胺神经毒性作用及机制的研究进展

李媛媛; 李娟; 杨根梦; 黄俭; 刘柳; 沈宝玉; 王婵; 许悦; 林纾丞; 曾晓锋

doi:10.12259/j.issn.2095-610X.S20210210

甲基苯丙胺神经毒性作用及机制的研究进展

doi: 10.12259/j.issn.2095-610X.S20210210

李媛媛¹,
李娟²,
杨根梦¹,
黄俭¹,
刘柳¹,
沈宝玉¹,
王婵¹,
许悦¹,
林纾丞¹,
曾晓锋^1, ,

1.
昆明医科大学法医学院法医病理学及法医临床学系
2.
基础医学院病原生物学与免疫学系，云南昆明　650500

基金项目: 国家自然科学基金资助项目（81560303， 81660310，81960340）；云南省教育厅科学研究基金资助项目（K13225141）

详细信息

作者简介:
李媛媛（1993～），女，内蒙古扎兰屯人，在读硕士研生，主要从事毒品神经毒性及滥用机制研究工作

通讯作者:
曾晓锋，E-mail：zxf2004033@163.com

中图分类号: R89
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- 被引次数: 0
出版历程
- 收稿日期: 2020-12-05
- 刊出日期: 2021-03-05

Research Progress on Neurotoxic Effects and Mechanism of Methamphetamine

1.
Dept. of Forensic Pathology and Clinical Medicine，School of Forensic Medicine
2.
Dept. of Pathogenic Biology and Immunology，Kunming Medical University，Kunming Yunnan 650500，China

摘要

摘要: 甲基苯丙胺（methamphetamine，METH）是一种严重威胁公共健康安全的兴奋性精神刺激药物。长期或高剂量滥用METH会引起明显的神经元损伤和神经毒性。METH诱导神经元损伤机制中，氧化应激、线粒体代谢损伤和神经炎症等神经毒性起重要作用。从METH神经毒性机制进行综述，重点描述反应性胶质细胞神经炎症作用，总结靶向METH诱导神经炎症药物，旨在进一步探讨METH诱导神经毒性的机制，为抑制METH神经毒性和药物研发提供新思路。
- 甲基苯丙胺 /
- 神经毒性 /
- 神经炎症 /
- 反应性胶质细胞增生
Abstract: Methamphetamine is a serious threat to public health and safety of mental excitatory drugs. Long-term abuse of METH will cause obvious neuronal injury and neurotoxicity. Oxidative stress, mitochondrial metabolic damage and neuroinflammation play important roles in meth-induced neuronal injury. In this paper, we reviewed the mechanism of neuronal injury induced by METH and the neurotoxicity mechanism of METH. The neuroinflammatory effect of reactive glial cells is described in detail, and the neuroinflammatory drugs induced by targeted METH are summarized. This article aims to further explore the mechanism of meth-induced neurotoxicity and provide new ideas for inhibiting meth neurotoxicity and drug development.
- Methamphetamine /
- Neurotoxicity /
- Neuroinflammation /
- Reactive gliosis

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参考文献(30)

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