星形胶质细胞-神经元转化体内诱导研究进展

铁金杉; 刘垚; 陈绍春

doi:10.12259/j.issn.2095-610X.S20210333

星形胶质细胞-神经元转化体内诱导研究进展

doi: 10.12259/j.issn.2095-610X.S20210333

昆明医科大学康复学院, 云南昆明　650500

基金项目: 国家自然科学基金资助项目（82060421）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（2018FE001-022）；昆明医科大学科技创新团队基金资助项目（CXTD201905）

详细信息

作者简介:
铁金杉，（1997～），女，云南昆明人，在读硕士研究生，主要从事神经退行性疾病康复相关研究工作

通讯作者:
陈绍春，E-mail：shaochunchen@126.com

中图分类号: R741.02
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- 被引次数: 0
出版历程
- 收稿日期: 2020-12-16
- 刊出日期: 2021-04-09

Advances in Research of Astrocyte-neuron Transformation in Vivo

School of Rehabilitation，Kunming Medical University，Kunming Yunnan 650500，China

摘要

摘要: 星形胶质细胞-神经元转化（星元转化）是21世纪神经科学的重要发现。星形胶质细胞在胶质细胞中数量最多，与神经元起源于相同的前体细胞，其向神经元转化的潜能为以神经元受损或丢失为特征的各类神经系统疾病的治疗带来新的希望。体外星元转化已有众多成功的实验，而体内星元转化的探索刚刚起步。现已发现可用转录因子、药物、MicroRNA等在模型动物体内诱导星元转化，阿尔茨海默病、脊髓损伤、局灶性中风、帕金森病等病理情况可诱发星元转化。对星形胶质细胞在正常及有关疾病模型动物体内转化为神经元的研究现状进行系统阐述，对星形胶质细胞重编程、向神经元转化并补充整合到受损的神经环路中的可能机制进行梳理。
- 星形胶质细胞 /
- 神经元 /
- 星元转化 /
- 重编程 /
- 神经系统疾病
Abstract: Astrocyte-neuron transformation （ANT） is an important discovery in neuroscience field in the 21st century. Astrocytes are the largest number of glial cells and originate from the same precursor cells as neurons. Their potential to transform into neurons has brought new hope for the treatment of various neurological diseases characterized by neuronal damage or loss. There have been many successful experiments on the transformation of astrocyte-neuron in vitro, but the exploration in vivo is just beginning. Transcription factors, drugs, and microRNAs have been found to induce this transformation in animal models. Meanwhile, astrocyte-neuron transformation can be induced by pathological conditions such as Alzheimer’ s disease, spinal cord injury, focal stroke, and Parkinson’ s disease. In this paper, we systematically review the current status of studies on the transformation of astrocytes into neurons in normal and related disease animal models, and sort out the possible mechanisms of astrocytes’ reprogramming, neuronal transformation, then supplement and integration into damaged neural circuits.
- Astrocytes /
- Neuron /
- Astrocytes neuron transformation /
- Reprogramming /
- Central nervous system diseases

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参考文献(27)

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