Research Progress of miRNA-145 in Malignant Tumors of Digestive System
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摘要: MiRNA-145在大多数消化系统恶性肿瘤中下调，普遍认为其是一种肿瘤抑制因子，可以通过作用于多种细胞因子、靶向多条通路中的各种基因从而抑制不同肿瘤细胞的生长，显著降低肿瘤细胞的扩散能力，提高肿瘤细胞对化疗药物的敏感性，进而发挥其抗肿瘤作用。就miRNA-145在消化系统恶性肿瘤中的表达及其作用进行综述。Abstract: MiRNA-145 is down-regulated in most malignant tumors of the digestive system and is widely considered as a tumor suppressor that can inhibit the growth of different tumor cells by acting on various cytokines and targeting various genes in multiple pathways, it can significantly reduce the proliferation of tumor cells, improve the sensitivity of tumor cells to chemotherapeutic drugs, and then exert its anti-tumor effect. In this paper, the expression and role of miRNA-145 in malignant tumors of digestive system were reviewed.
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Key words:
- miRNAs /
- miRNA-145 /
- Digestive system malignancy
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表 1 miRNA-145在消化系统恶性肿瘤中的表达
Table 1. Expression of miRNA-145 in malignant tumors of digestive system
肿瘤类型 样本类型 样本量 方法 表达作用 参考文献 ESCC 组织 50 qRT-PCR ↓抑制转移/侵袭/EMT [6] ESCC 组织 29 qPCR ↓抑制侵袭 [7] HCC 组织 139 qRT-PCR ↓ 预后 [8] GBC 组织 82 qRT-PCR ↓ 预后 [9] PC 组织 20 RT-PCR ↓ 抑制增殖、迁移和侵袭 [10] CRC 组织 43 qPCR ↓ 抑制侵袭和转移 [11] CRC 组织 202 qRT-PCR ↑ 促进转移和侵袭 [12] ↓：miRNA-145 下调；↑：miRNA-145 上调；CRC：结直肠癌；HCC：肝细胞癌；ESCC：食管鳞状细胞癌；PC：胰腺癌；GBC：胆囊癌；EMT：上皮-间质转化；qPCR：定量聚合酶链反应；qRT-PCR：实时荧光定量聚合酶链反应；RT-PCR：实时荧光定量聚合酶链反应。 
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