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心房颤动与心房代谢重构的研究进展

李昊 王静 杨萍

李昊, 王静, 杨萍. 心房颤动与心房代谢重构的研究进展[J]. 昆明医科大学学报, 2021, 42(3): 149-154. doi: 10.12259/j.issn.2095-610X.S20210335
引用本文: 李昊, 王静, 杨萍. 心房颤动与心房代谢重构的研究进展[J]. 昆明医科大学学报, 2021, 42(3): 149-154. doi: 10.12259/j.issn.2095-610X.S20210335
Hao LI, Jing WANG, Ping YANG. Research Progress of Atrial Fibrillation and Atrial Metabolic Remodeling[J]. Journal of Kunming Medical University, 2021, 42(3): 149-154. doi: 10.12259/j.issn.2095-610X.S20210335
Citation: Hao LI, Jing WANG, Ping YANG. Research Progress of Atrial Fibrillation and Atrial Metabolic Remodeling[J]. Journal of Kunming Medical University, 2021, 42(3): 149-154. doi: 10.12259/j.issn.2095-610X.S20210335

心房颤动与心房代谢重构的研究进展

doi: 10.12259/j.issn.2095-610X.S20210335
基金项目: 国家自然科学基金资助项目(81960069)
详细信息
    作者简介:

    李昊(1994~),男,云南昆明人,在读硕士研究生,主要从事心血管内科、心脏起搏及心律失常射频消融、心房颤动所致代谢重构研究工作

    通讯作者:

    杨萍,E-mail: 15877990331@163.com

  • 中图分类号: R54

Research Progress of Atrial Fibrillation and Atrial Metabolic Remodeling

  • 摘要: 心房颤动(简称房颤)是最常见的心律失常之一,常导致高致残率和高致死率。心房电重构、结构重构、代谢重构等是房颤发生的主要原因,重构又促进房颤发生和维持,由此形成恶性循环。主要介绍与房颤相关的代谢重构及针对代谢重构干预的研究进展。
  • [1] Chugh S S,Havmoeller R,Narayanan K,et al. Worldwide epidemiology of atrial fibrillation:A global burden of disease 2010 study[J]. Circulation,2014,129(8):837-847. doi: 10.1161/CIRCULATIONAHA.113.005119
    [2] Morin D P,Bernard M L,Madias C,et al. The state of the art:Atrial fibrillation epidemiology,prevention,and treatment[J]. Mayo Clinic Proceedings,2016,91(12):1778-1792. doi: 10.1016/j.mayocp.2016.08.022
    [3] Staerk L,Sherer J A,Ko D,et al. Atrial fibrillation:Epidemiology,pathophysiology,and clinical outcomes[J]. Circulation Research,2017,120(9):1501-1517. doi: 10.1161/CIRCRESAHA.117.309732
    [4] Kelly A van Bragt,Nasrallah H M,Marion K,et al. Atrial supply-demand balance in healthy adult pigs:coronary blood flow,oxygen extraction,and lactate production during acute atrial fibrillation[J]. Cardiovascular Research,2014,101(1):9-19. doi: 10.1093/cvr/cvt239
    [5] van Bilsen M,Smeets P J,Gilde A J,et al. Metabolic remodelling of the failing heart:the cardiac burn-out syndrome?[J]. Cardiovasc Res,2004,61(2):218-260. doi: 10.1016/j.cardiores.2003.11.014
    [6] Maria Z,Campolo A R,Lacombe V A. Diabetes Alters the expression and translocation of the insulin-sensitive glucose transporters 4 and 8 in the atrial[J]. PLoS One,2015,10(12):e0146033. doi: 10.1371/journal.pone.0146033
    [7] Lenski M,Schleider G,Kohlhaas M,et al. Arrhythmia causes lipid accumulation and reduced glucose uptake[J]. Basic Res Cardiol,2015,110(4):1-19.
    [8] 孙殿珉,郑哲,杨克明,等. 心房肌葡萄糖转运体-3的水平对冠心病患者冠脉旁路移植术后新发房颤风险的影响[J]. 中国分子心脏病学杂志,2009,9(3):161-163.
    [9] Ono N,Hayashi H,Kawase A,et al. Spontaneous atrial fibrillation initiated by triggered activity near the pulmonary veins in aged rats subjected to glycolytic inhibition[J]. AJP Heart and Circulatory Physiology,2007,292(1):H639-648. doi: 10.1152/ajpheart.00445.2006
    [10] Davogustto G,Dillon W,Salazar R,et al. The warburg effect in the heart:increased glucose metabolism drives cardiomyocyte hypertrophy in response to adrenergic stimulation[J]. Journal of the American College of Cardiology,2018,71(11):A802-812. doi: 10.1016/S0735-1097(18)31343-3
    [11] Hu H J,Zhang C,Tang Z H,et al. Regulating the Warburg effect on metabolic stress and myocardial fibrosis remodeling and atrial intracardiac waveform activity induced by atrial fibrillation[J]. Biochem Biophys Res Commun,2019,516(3):653-660. doi: 10.1016/j.bbrc.2019.06.055
    [12] Liu Y,Bai F,Liu N,et al. Metformin improves lipid metabolism and reverses the Warburg effect in a canine model of chronic atrial fibrillation[J]. BMC Cardiovasc Disord,2020,20(1):50-56. doi: 10.1186/s12872-020-01359-7
    [13] Kourliouros A,Yin X,Didangelos A,et al. Substrate modifications precede the development of atrial fibrillation after cardiac surgery:A proteomic study[J]. Annals of Thoracic Surgery,2011,92(1):104-110. doi: 10.1016/j.athoracsur.2011.03.071
    [14] Neglia D,Caterina A D,Marraccini P,et al. Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy[J]. AJP Heart and Circulatory Physiology,2008,293(6):H3270-3278.
    [15] Bonnet D,Martin D,Lonlay P D,et al. Arrhythmias and conduction defects as presenting symptoms of fatty acid oxidation disorders in children[J]. Circulation,1999,100(22):2248-2253. doi: 10.1161/01.CIR.100.22.2248
    [16] Lim S,Lee K S,Lee J E,et al. Effect of a new PPAR-gamma agonist,lobeglitazone,on neointimal formation after balloon injury in rats and the development of atherosclerosis[J]. Atherosclerosis,2015,243(1):107-119. doi: 10.1016/j.atherosclerosis.2015.08.037
    [17] Liu G Z,Hou T T,Yuan Y,et al. Fenofibrate inhibits atrial metabolic remodeling in atrial fibrillation through PPAR-α/Sirt1/PGC-1α pathway[J]. Br J Pharmacol,2016,173(6):1095-1109. doi: 10.1111/bph.13438
    [18] Chao T F,Leu H B,Huang C C,et al. Thiazolidinediones can prevent new onset atrial fibrillation in patients with non-insulin dependent diabetes[J]. International Journal of Cardiology,2012,156(2):199-202. doi: 10.1016/j.ijcard.2011.08.081
    [19] Shingu Y,Yokota T,Takada S,et al. Decreased gene expression of fatty acid binding protein 3 in the atrium of patients with new onset of atrial fibrillation in cardiac perioperative phase[J]. Journal of Cardiology,2017,71(1):156-172.
    [20] Rader F,Pujara A C,Pattakos G,et al. Perioperative heart-type fatty acid binding protein levels in atrial fibrillation after cardiac surgery[J]. Heart Rhythm,2013,10(2):153-157. doi: 10.1016/j.hrthm.2012.10.007
    [21] Jie Q Q,Li G,Duan J B,et al. Remodeling of myocardial energy and metabolic homeostasis in a sheep model of persistent atrial fibrillation[J]. Biochem Biophys Res Commun,2019,517(1):8-14. doi: 10.1016/j.bbrc.2019.05.112
    [22] Neuman R B,Bloom H L,Shukrullah I,et al. Oxidative stress markers are associated with persistent atrial fibrillation[J]. Clinical Chemistry,2007,53(9):1652-1657. doi: 10.1373/clinchem.2006.083923
    [23] Shimano M,Shibata R,Inden Y,et al. Reactive oxidative metabolites are associated with atrial conduction disturbance in patients with atrial fibrillation[J]. HEART RHYTHM,2009,6(7):935-940. doi: 10.1016/j.hrthm.2009.03.012
    [24] Emelyanova L,Ashary Z,Cosic M,et al. Selective downregulation of mitochondrial electron transport chain activity and increased oxidative stress in human atrial fibrillation[J]. American Journal of Physiology - Heart and Circulatory Physiology,2016,311(1):H54-H63. doi: 10.1152/ajpheart.00699.2015
    [25] Slagsvold K H,Johnsen A B,Rognmo O,et al. Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation[J]. Physiological Genomics,2014,46(14):505-511. doi: 10.1152/physiolgenomics.00042.2014
    [26] Chen G,Guo H,Song Y,et al. Long non-coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes[J]. Molecular Medicine Reports,2016,14(6):5311-5317. doi: 10.3892/mmr.2016.5893
    [27] Soltész B,Urbancsek R,Pis O,et al. Quantification of peripheral whole blood,cell-free plasma and exosome encapsulated mitochondrial DNA copy numbers in patients with atrial fibrillation[J]. J Biotechnol,2019,299:66-71. doi: 10.1016/j.jbiotec.2019.04.018
    [28] Dong J,Zhao J,Zhang M,et al. 3-Adrenoceptor impairs mitochondrial biogenesis and energy metabolism during rapid atrial pacing-induced atrial fibrillation[J]. Journal of Cardiovascular Pharmacology and Therapeutics,2015,21(1):114-126.
    [29] UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)[J]. Lancet,1998,352(9131):854-865. doi: 10.1016/S0140-6736(98)07037-8
    [30] Milton Packer. Disease treatment interactions in the management of patients with obesity and diabetes who have atrial fibrillation:the potential mediating influence of epicardial adipose tissue[J]. Cardiovascular Diabetology,2019,18(1):121-147. doi: 10.1186/s12933-019-0927-9
    [31] Chang S H,Wu L S,Chiou M J,et al. Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus:A population-based dynamic cohort and in vitro studies[J]. Cardiovascular Diabetology,2014,13(1):462-476.
    [32] Adam O,Lavall D,Theobald K,et al. Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation[J]. Journal of the American College of Cardiology,2010,55(5):469-480. doi: 10.1016/j.jacc.2009.08.064
    [33] Khan J A,Laurikka J O,Jrvinen O H,et al. Early postoperative statin administration does not affect the rate of atrial fibrillation after cardiac surgery[J]. Eur J Cardiothorac Surg,2020,13(1):262-281.
    [34] Tseng C H,Chung W J,Li C Y,et al. Statins reduce new-onset atrial fibrillation after acute myocardial infarction:A nationwide study[J]. Medicine (Baltimore),2020,99(2):185-202.
    [35] Lan F,Weikel,K A,Cacicedo,J M,et al. Resveratrol-induced AMP-activated protein kinase activation is cell-type dependent:Lessons from basic research for clinical application[J]. Nutrients,2017,9(7):751-753. doi: 10.3390/nu9070751
    [36] Chong E,Chang S L,Hsiao Y W,et al. Resveratrol,a red wine antioxidant,reduces atrial fibrillation susceptibility in the failing heart by PI3K/AKT/eNOS signaling pathway activation[J]. Heart Rhythm,2015,12(5):1046-1056. doi: 10.1016/j.hrthm.2015.01.044
    [37] Wang Z,Cao Y,Yin Q,et al. Activation of AMPK alleviates cardiopulmonary bypass-induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder[J]. Cardiovasc Ther,2018,36(6):124-152.
    [38] Zhang H,Liu B,Li T,et al. AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia[J]. Int J Mol Med,2018,41(1):69-76.
    [39] Zhang Z,Zhang X,Korantzopoulos P,et al. Thiazolidinedione use and atrial fibrillation in diabetic patients:a meta-analysis[J]. BMC Cardiovascular Disorders,2017,17(1):96-102. doi: 10.1186/s12872-017-0531-4
    [40] Nakamura H,Niwano S,Niwano H,et al. Liraglutide suppresses atrial electrophysiological changes[J]. Heart Vessels,2019,34(8):1389-1393. doi: 10.1007/s00380-018-01327-4
    [41] Zhang X,Zhang Z,Zhao Y,et al. Alogliptin,a dipeptidyl peptidase-4 inhibitor,alleviates atrial remodeling and improves mitochondrial function and biogenesis in diabetic rabbits[J]. J Am Heart Assoc,2017,6(5):128-136.
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  • 收稿日期:  2020-12-30
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