Correlation Study of Blood Preβ1-HDL Predictive Value of Coronary Artery Disease Severity in Patients with Coronary Heart Disease
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摘要:
目的 探讨preβ1-HDL对冠心病患者冠脉病变严重程度预测价值的相关性。 方法 在昆明市第一人民医院行冠脉介入诊断和\或治疗的90例患者，顺序入组，其中冠心病患者70例（其中冠心病单支病变15例，冠心病多支病变55例），冠脉正常患者20例。收集各组临床基线资料。采用ELISA法测定血preβ1-HDL浓度。用SPSS进行统计分析。 结果 在不同冠脉病变严重程度患者中血preβ1-HDL水平，差异有统计学意义（P < 0.05）。Preβ1-HDL浓度与冠脉Gensini评分呈正相关（P < 0.000），相关性为（r = 0.782）。Preβ1-HDL浓度与cTnT呈正相关（P < 0.000），相关性为（r = 0.421）。血Preβ1-HDL的ROC曲线下面积（AUC）为0.993，诊断界值为3.66，敏感度和特异度分别为100%和94.7%。 结论 初步发现血Preβ1-HDL浓度可以作为预测冠心病冠脉病变严重程度的新指标。 -
关键词:
- preβ1-HDL /
- 冠状动脉粥样硬化性心脏病 /
- 冠脉Gensini评分
Abstract:Objective To investigate the correlation between Pre β1-HDL and the predictive value of coronary artery disease severity in patients with coronary heart disease. Methods In this study, 90 patients undergoing coronary intervention diagnosis and/or treatment in our hospital were enrolled sequentially. Among them, there were 70 patients with coronary artery disease （including 15 patients with single coronary artery disease, 55 patients with multiple coronary artery disease）and 20 patients with normal coronary artery disease. Clinical baseline data of each group were collected. Blood preβ1-HDL concentration was determined by ELISA. SPSS was used for statistical analysis. Results The results of this study showed that blood pre β1-HDL levels in patients with different severity of coronary artery disease had the statistically significant differences （P < 0.05）. Preβ1-HDL concentration was positively correlated with coronary Gensini score （P < 0.000）, and the correlation was （r = 0.782）. Preβ1-HDL concentration was positively correlated with cTnT （P < 0.000）, and the correlation was （r = 0.421）. The area under ROC curve（AUC） of blood Pre β1-HDL was 0.993, the diagnostic threshold was 3.66, and the sensitivity and specificity were 100% and 94.7%, respectively. Conclusion Blood Pre β1-HDL concentration has been found to be a new indicator to predict the severity of coronary artery disease. -
图 1 血Preβ1HDL、cTnT、CKMB、Mb在冠心病诊断中的敏感性及特异性
Figure 1. Preβ1HDL、cTnT、CKMB、Mb in the diagnosis of CAD sensitivity and specificity
表 1 患者基线临床资料[（
$\bar x \pm s$ ）/（n）%]Table 1. patients baseline clinical data [（
$\bar x \pm s$ ）/（n）%]项目 所有患者（n = 90） 冠脉多支病变（n = 55） 冠脉单支病变（n = 15） 冠脉正常（n = 20） F/Z P 年龄（岁） 63.52 ± 9.89 65.91 ± 8.36 64.13 ± 11.10 56.10 ± 9.76 2.368 0.117 男性 48（53.3） 32（58.1） 8（50） 8（42.1） 0.034 0.784 吸烟（n）% 47（52.2） 32（58.2） 7（43.8） 8（42.1） 1.275 0.426 高血压（n）% 83（92.2） 51（92.7） 15（93.7） 17（89.5） 0.023 0.872 TG（mmol/L） 2.03 ± 1.40 2.17 ± 1.63 1.83 ± 0.98 1.80 ± 0.82 0.376 0.512 TC（mmol/L） 4.40 ± 1.23 4.42 ± 1.34 4.35 ± 1.25 4.39 ± 0.87 0.012 0.982 LDLC（mmol/L） 2.44 ± 0.98 2.50 ± 1.05 2.20 ± 1.01 2.47 ± 0.72 1.293 0.459 BUN（mmol/L） 5.71 ± 2.93 6.05 ± 3.41 5.11 ± 1.95 5.22 ± 1.83 0.972 0.382 Cr（µmol/L） 84.25 ± 49.87 89.08 ± 62.32 76.08 ± 13.50 77.16 ± 17.45 0.385 0.520 eGFR（mL/min） 91.42 ± 26.03 89.98 ± 28.49 94.31 ± 22.15 93.16 ± 22.08 0.033 0.802 K（mmol/L） 4.15 ± 0.39 4.16 ± 0.41 4.13 ± 0.26 4.10 ± 0.42 0.026 0.827 Na（mmol/L） 140.54 ± 2.79 140.36 ± 2.78 140.36 ± 2.93 141.25 ± 2.19 1.183 0.439 CL（mmol/L） 106.62 ± 3.43 106.28 ± 3.44 107.32 ± 3.54 107.00 ± 3.36 1.251 0.499 Hb（g/L） 141.90 ± 16.96 138.80 ± 16.93 145.00 ± 16.09 148.26 ± 16.29 2.748 0.124 PLT（×109/L） 217.81 ± 63.13 211.91 ± 60.90 212.12 ± 59.36 239.68 ± 70.71 1.473 0.238 WBC（×1012/L） 6.92 ± 2.37 6.98 ± 2.59 6.70 ± 2.20 6.93 ± 1.84 0.254 0.897 n百分比（n%） 64.94 ± 10.15 65.16 ± 11.01 64.67 ± 9.49 64.52 ± 8.37 0.117 0.934 HCY（mmol/L） 13.87 ± 4.61 14.17 ± 5.21 13.34 ± 3.08 13.45 ± 3.87 0.042 0.748 
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表 2 在不同冠脉病变组中患者血preβ1-HDL的水平（
$\bar x \pm s$ ）Table 2. Blood Preβ1-HDL levels in patients with different coronary artery disease groups （
$\bar x \pm s$ ）项目 冠脉多支病变 冠脉单支病变 冠脉正常 P Preβ1-HDL（µg/mL） 10.69 ± 3.61 5.86 ± 2.22 2.66 ± 0.93 < 0.001* Gensini评分 61.07 ± 34.16 21.75 ± 21.06 − < 0.001* *P < 0.05。
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表 3 Preβ1-HDL与冠脉Gensini评分及cTnT相关性分析
Table 3. Preβ1-HDL with coronary Gensini score and cTnT correlation analysis
Preβ1HDL r P 冠脉Gensini评分 0.782** < 0.001 hsCTnT 0.421** < 0.001 **在.01水平（双侧）上显著相关。
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表 4 本研究中血Preβ1HDL、cTnT、CKMB、Mb在冠心病诊断中的ROC曲线
Table 4. ROC curve of the Preβ1HDL、cTnT、CKMB、Mbin the diagnosis of CAD
项目 CUT OFF 灵敏度（%） 特异度（%） AUC P Preβ1HDL（µg/mL） 3.66 100 94.7 0.993 0.000 cTnT（mmol/L） 0.009 73.2 78.9 0.744 0.001 CKMB（mmol/L） 1.65 67.6 63.2 0.669 0.024 Mb（mmol/L） 26 52.1 89.5 0.723 0.003
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