组蛋白和TLRs在静脉血栓栓塞性疾病中的作用机制

吴婕; 刘珺; 张燕; 任莉; 党彦丽

doi:10.12259/j.issn.2095-610X.S20210530

组蛋白和TLRs在静脉血栓栓塞性疾病中的作用机制

doi: 10.12259/j.issn.2095-610X.S20210530

云南省第一人民医院/昆明理工大学附属医院产科云南昆明　650032

基金项目: 国家自然科学基金资助项目（82060608）；云南省卫生健康委员会医学领军人才基金资助项目（L-2018006）

详细信息

作者简介:
吴婕（1983～），女，云南昆明人，医学硕士，主治医师，主要从事产科临床工作

通讯作者:
刘珺，E-mail：932700960@qq.com

中图分类号: R543.6
计量
- 文章访问数: 3166
- HTML全文浏览量: 2217
- PDF下载量: 8
- 被引次数: 0
出版历程
- 收稿日期: 2021-12-13
- 网络出版日期: 2021-06-03
- 刊出日期: 2021-05-20

The Mechanism of Histones and TLRs in Venous Thrombotic Diseases

Dept. of Obstetrics，The First People’s Hospital of Yunnan Province; The Affiliated Hospital of Kunming University of Science and Technology，Kunming Yunnan 650032，China

摘要

摘要: 近年来随着产科高危妊娠的增加及诊断技术的提高，临床对妊娠合并静脉血栓性疾病的关注度逐年增加，尽管已识别出诱发深静脉血栓的各种危险因素，但血栓形成的机制尚不完全清楚。研究表明组蛋白在静脉血栓疾病中有着重要作用，通过TLRs或炎症通路激发炎症，促发血栓形成。旨在对组蛋白通过TLRs激发炎症诱发静脉血栓性疾病作一概述，为以后产科静脉血栓性疾病的预防和治疗提供新的突破点。
- 组蛋白 /
- TLRs /
- 静脉血栓性疾病
Abstract: In recent years, due to the increase of high-risk pregnancies in obstetrics and the improvement of diagnostic techniques, clinical attention to pregnancy complicated with venous thrombotic diseases is increasing from year to year. Although various risk factors that induce deep vein thrombosis have been identified, the mechanism of thrombosis is not yet completely clear. Studies have demonstrated that histones play a key role in venous thrombotic diseases, mediating the production of thrombus through inflammatory pathways or TLRs that activate inflammation.This article aims to provide an overview of histone-induced venous thrombotic diseases through TLRs to stimulate inflammation, and provide a new breakthrough point for the prevention and treatment of obstetric venous thrombotic diseases in the future.
- Histones /
- TLRs /
- Venous thrombotic diseases

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参考文献(28)

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