Effect of Atropine Eye Drops Combined with Visual Function Training in Patients with Mild Myopia and Its Influence on Visual Acuity
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摘要:
目的 探讨0.01%阿托品滴眼液联合视功能训练在轻度近视患者中的疗效观察及对视力水平的影响研究。 方法 选取2019年10月至2020年10月玉溪市人民医院眼科诊治的轻度近视患者86例，随机分为2组，对照组给予0.01%阿托品滴眼液治疗，研究组给予0.01%阿托品滴眼液联合视功能训练治疗。比较2组瞳孔直径、裸眼视力、眼轴长度、屈光度、眼压、眼调节灵敏度变化情况。 结果 研究组瞳孔直径、裸眼视力均高于对照组，屈光度低于对照组（P < 0.05）；2组治疗前、治疗1个月、3个月、6个月时眼压对比均无明显差异（P > 0.05）；2组治疗1个月、3个月、6个月时的并发症发生率对比无明显差异（P > 0.05）；研究组治疗3个月、6个月时眼调节灵敏度均高于对照组（P < 0.05）。 结论 轻度近视患者使用0.01%阿托品滴眼液联合视功能训练治疗，可明显调节眼调节灵敏度，控制屈光度、眼轴长度增长，改善患者视力水平，相较于单用0.01%阿托品滴眼液未明显增加并发症发生率，眼压未出现明显大幅度变化，更有效的进行近视防控、改善眼部调节功能，治疗效果较为理想，值得临床进一步推广应用。 Abstract:Objective To investigate the efficacy of 0.01% atropine eye drops combined with visual function training in patients with mild myopia and its influence on visual acuity. Methods A total of 86 patients with mild myopia treated in Yuxi People’ s Hospital from October 2019 to October 2020 were selected and randomly divided into two groups.The control group was treated with 0.01% atropine eye drops, and the research group was treated with 0.01% atropine eye drops combined with visual function training.The changes of pupil diameter, naked visual acuity, axial length, diopter, intraocular pressure and ocular adjustment sensitivity were compared between the two groups. Results The pupil diameter and naked eye vision of the study group were higher than those of the control group, and the diopter was lower than that of the control group （P < 0.05）. There was no significant difference in IOP between the two groups before treatment, at 1 month, 3 months and 6 months after treatment （P > 0.05）. There was no significant difference in the incidence of complications between the two groups at 1 month, 3 months and 6 months after treatment （P > 0.05）. The sensitivity of eye regulation in the study group was higher than that in the control group at 3 months and 6 months （P < 0.05）. Conclusions mild myopia patients treated with 0.01% atropine eye drops combined visual function training, can obviously regulate eye sensitivity adjustment, control diopter, axial length growth, improve eyesight, compared with 0.01% atropine eye drops alone did not significantly increase the incidence of complications, intraocular pressure does not appear drastically changes obviously, more effective for myopia prevention and control, improve eye adjustment function, treatment effect is more ideal, is worth further clinical application. -
Key words:
- Vision level /
- Adjust the sensitivity /
- Mild myopia /
- Visual function training /
- Atropine eye drops
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表 1 2组瞳孔直径、裸眼视力、眼轴长度、屈光度对比（
$\bar x \pm s $ ）Table 1. Comparison of pupil diameter，naked eye vision，axial length and diopter between the two groups （
$\bar x \pm s $ ）组别 n 瞳孔直径（mm） 裸眼视力 眼轴长度（mm） 屈光度（D） 干预前 干预后 干预前 干预后 干预前 干预后 干预前 干预后 对照组 43 3.6 ± 0.6 5.0 ± 0.8 0.50 ± 0.07 0.64 ± 0.05 43.32 ± 0.31 43.07 ± 0.34 −1.62 ± 0.23 −1.20 ± 0.23 研究组 43 3.5 ± 0.7 6.6 ± 0.9 0.51 ± 0.07 0.73 ± 0.06 43.47 ± 0.34 43.01 ± 0.33 −1.63 ± 0.21 −0.60 ± 0.14 t 1.448 16.263 0.67 13.198 1.652 0.714 0.91 11.214 P > 0.05 < 0.05 > 0.05 < 0.05 > 0.05 > 0.05 > 0.05 < 0.05 
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表 2 2组眼压对比（
$\bar x \pm s $ ）Table 2. Comparison of intraocular pressure between the two groups （
$\bar x \pm s $ ）组别 n 治疗前 治疗1个月 治疗3个月 治疗6个月 对照组 43 18.12 ± 0.13 18.28 ± 0.14 18.28 ± 0.11 18.42 ± 0.11 研究组 43 18.16 ± 0.15 18.32 ± 0.16 18.28 ± 0.12 18.43 ± 0.14 t / 0.647 0.799 0.508 0.301 P / > 0.05 > 0.05 > 0.05 > 0.05
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表 3 2组并发症对比[n（%）]
Table 3. Comparison of complications between the two groups [n（%）]
组别 n 治疗1个月 治疗3个月 治疗6个月 对照组 43 5（11.6） 5（11.6） 4（9.3） 研究组 43 6（14.0） 5（11.6） 5（11.6） χ2 / 1.246 0.365 1.156 P / > 0.05 > 0.05 > 0.05
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表 4 2组眼调节灵敏度对比（
$\bar x \pm s $ ）Table 4. Comparison of ocular adjustment sensitivity between the two groups （
$\bar x \pm s $ ）组别 n 治疗前 治疗1个月 治疗3个月 治疗6个月 对照组 43 7.78 ± 1.36 8.88 ± 2.31 12.35 ± 2.28 14.68 ± 2.79 研究组 43 7.76 ± 1.40 9.17 ± 2.08 15.17 ± 2.60 18.50 ± 3.01 t / 0.670 1.401 12.606 14.931 P / > 0.05 > 0.05 < 0.05 < 0.05
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