Correlation Between the Neutrophil-lymphocyte Ratio and Renal Damage in Systemic Lupus Erythematosus Patients
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摘要:
目的 探讨中性粒细胞/淋巴细胞比值（neutrophil-lymphocyte ratio，NLR）与系统性红斑狼疮（systemic lupus erythematosus，SLE）患者肾脏损害的相关性。 方法 选取昆明医科大学第一附属医院风湿免疫科确诊的SLE患者共410例。根据有无肾脏损害，分为非狼疮肾炎组（非LN组）和狼疮肾炎组（LN组），比较2组NLR的差异，分析NLR与狼疮患者肾脏损害的相关性。 结果 LN组NLR显著高于非LN组的SLE患者，差异有统计学意义（P < 0.05）。SLE患者的NLR分别与白细胞计数、中性粒细胞计数、血肌酐、血尿素、ESR、CRP、PCT、24 h尿蛋白呈正相关，与淋巴细胞计数、总蛋白、白蛋白、球蛋白呈负相关。 结论 NLR可作为评估SLE患者肾脏损害的一项辅助指标。 -
关键词:
- 中性粒细胞/淋巴细胞比值 /
- 系统性红斑狼疮
Abstract:Objective To evaluate the association between neutrophil-lymphocyte ratio （NLR） and renal damage in patients with systemic lupus erythematosus （SLE）. Methods A total of 410 patients with SLE from the Department of Rheumatology and Immunology of the First Affiliated Hospital of Kunming Medical University were selected. According to whether accompanied by renal involvement, patients with SLE were divided into non-lupus nephritis group （non-LN group） and lupus nephritis group （LN group）. The differences in NLR between the two groups were compared, and the correlation between NLR and renal damage was analyzed. Results The NLR of LN group was significantly higher than that of SLE patients in non-LN group, and the difference wsa statistically significant （P < 0.05）. The NLR of SLE patients were positively correlated with leukocyte count, neutrophils count, serum creatinine, blood urea nitrogen, ESR, CRP, PCT and 24-hour urine protein, and negatively correlated with lymphocyte count, total protein, albumin and globulin, respectively. Conclusion NLR can be used as an auxiliary index to evaluate renal damage in SLE patients. -
Key words:
- Neutrophil-lymphocyte ratio /
- Systemic lupus erythematosus
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图 1 NLR预测SLE是否伴发肾脏损害的ROC曲线
Figure 1. Receiver operating characteristic curve of NLR in predicting renal damage in SLE
表 1 2组患者一般资料和实验室指标的比较
Table 1. Comparison of general data and laboratory indicators between the two groups
项目 非LN组（n = 249） LN组（n = 161） P 年龄（岁） 35.0 ± 13.1 36.1 ± 14.2 0.374 性别（女/男） 230/19（92%） 143/18（89%） 0.221 NLR 3.1（1.6，5.2） 3.8（2.8，7.1） < 0.001 WBC（109/L） 4.7（3.4，6.4） 5.4（4.3，7.6） < 0.001 N（109/L） 2.9（2.0，4.7） 4.0（2.8，5.3） < 0.001 L（109/L） 1.1（0.7，1.5） 0.9（0.6，1.4） 0.694 总蛋白 68.2（61.3，74.4） 59.0（49.1，67.5） < 0.001 白蛋白 34.5（29.8，38.7） 28.1（23.3，34.2） < 0.001 球蛋白 32.3（28.1，37.4） 29.4（22.9，35.7） < 0.001 血尿素（mmol/L） 4.0（3.2，5.8） 6.6（4.1，10.2） < 0.001 血尿酸（µmol/L） 300.8（242.0，366.8） 375.7（297.1，443.2） < 0.001 血肌酐（µmol/L） 60.0（51.5，81.0） 76.2（57.6，121.4） < 0.001 24 h尿蛋白 0.2（0.1，0.5） 1.8（0.6，3.7） < 0.001 补体C3（g/L） 0.6（0.4，0.9） 0.5（0.3，0.7） < 0.001 补体C4（g/L） 0.1（0.1，0.2） 0.1（0.1，0.2） 0.104 ESR（mm/h） 34.0（17.0，60.0） 40.0（20.8，61.5） 0.054 CRP（mg/L） 5.0（3.1，14.9） 3.6（2.1，11.7） 0.314 PCT（ng/mL） 0.1（0.0，0.2） 0.1（0.1，0.3） 0.107 抗ds-DNA抗体（%） 32.9 49.3 0.001 抗Sm抗体（%） 51.7 45.8 0.253 抗核小体抗体（%） 48.2 52.3 0.496 抗组蛋白抗体（%） 49.2 50.5 0.839 
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