Effect of Two Sequential Estrogen Therapy on Endometrium and Prognosis after Intrauterine Adhesion
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摘要:
目的 比较芬吗通、红丽来联合达芙通对宫腔粘连患者的治疗效果及预后情况。 方法 对2019年6月至2020年6月新疆医科大学第一附属医院妇科收治的70例宫腔粘连患者进行研究，A组服用芬吗通，B组服用红丽来联合达芙通，比较2组治疗后月经改善情况、宫腔恢复情况、妊娠率及不良反应发生率。 结果 较术前，A、B 2组均能够有效提高月经改善情况和宫腔恢复情况。其中，B组较A组能够促进月经量的恢复（P < 0.05）；而2组间的不良反应发生率及妊娠率比较，差异无统计学意义（P > 0.05）。 结论 红丽来联合达芙通能够提高宫腔粘连患者的预后，且安全性较高，值得应用于临床。 Abstract:Objective To compare the therapeutic effect and prognosis of Femostong and Honglilai combined with Duphaton in patients with intrauterine adhesions. Methods A total of 70 patients with intrauterine adhesions admitted to the first Affiliated Hospital of Xinjiang Medical University from June 2019 to June 2020 were studied. Group A was given Femostong and group B was given Honglilai combined with Duphaton. After treatment, the menstrual improvement, uterine recovery, pregnancy rate and adverse reaction rate of the two groups were compared. Results Compared with preoperation, both groups A and B could effectively improve the menstrual improvement and uterine cavity recovery. Among them, group B achieved more significant results in restoring menstrual volume than group A （P < 0.05）. There was no difference in the incidence of adverse reactions and pregnancy rate between the two groups （P > 0.05）. Conclusion Honglilai combined with Duphaton can improve the prognosis of patients with intrauterine adhesion more effectively, and the safety is higher, which is worthy of clinical application. -
Key words:
- Intrauterine adhesion /
- Femostong /
- Duphaton /
- Honglilai
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表 1 两组患者治疗后累积宫腔范围、粘连类型情况的比较（
${{\bar x}} \pm s$ ）Table 1. Comparison of cumulative intrauterine cavity range and type of adhesions between two groups after treatment （
${{\bar x}} \pm s$ ）分组 累积范围 F P 粘连类型 F P 治疗前 治疗1周 治疗1个月 治疗3个月 治疗前 治疗1周 治疗1个月 治疗3个月 A 1.61 ± 0.09 0.12 ± 0.06* 0.21 ± 0.07* 0.12 ± 0.06* 317.644 < 0.001 1.39 ± 0.09 0.12 ± 0.06* 0.21 ± 0.01* 0.12 ± 0.06* 286.617 < 0.001 B 1.62 ± 0.08 0.16 ± 0.06* 0.38 ± 0.08* 0.24 ± 0.07* 73.127 < 0.001 1.62 ± 0.008 0.16 ± 0.06 0.38 ± 0.08* 0.24 ± 0.07* 376.533 < 0.001 t 0.532 1.533 1.328 0.532 1.628 1.328 P 0.596 0.13 0.189 0.596 0.108 0.189 与治疗前比较，*P < 0.05。 
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表 2 2组患者治疗后内膜厚度及月经改善情况的比较（
${{\bar x}} \pm s$ ）Table 2. Comparison of the improvement of endometrial thickness and menstruation between two groups after treatment （
${{\bar x}} \pm s$ ）分组 内膜厚度 F P 月经量 F P 治疗前 治疗1周 治疗1个月 治疗3个月 治疗前 治疗1个月 治疗3个月 A组 3.14 ± 0.79 6.9 ± 1.22* 6.76 ± 0.94* 7.04 ± 1.24* 9.433 < 0.001 1.88 ± 0.55 0.24 ± 0.56* 0.21 ± 0.08* 61.79 < 0.001 B组 3.45 ± 0.72 6.88 ± 1.22* 6.71 ± 0.91* 7.04 ± 1.30* 7.833 < 0.001 2.27 ± 0.13 0.49 ± 0.11*# 0.41 ± 0.10*# 341.979 < 0.001 t 0.767 0.986 0.753 9.512 10.16 P 0.447 0.33 0.455 < 0.001 < 0.001 与治疗前比较，*P < 0.05；与B组比较，#P < 0.05。
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表 3 2组患者治疗后不良反应发生率及妊娠率的比较[n（%）]
Table 3. Comparison of the incidence of adverse reactions and pregnancy rate between 2 groups after treatment [n（%）]
分组 n 下腹隐痛（n） 乳房胀痛（n） 恶心（n） 头痛（n） 不良反应发生率 成功妊娠（n） 妊娠率 A组 33 2 0 1 1 4（12.12） 28 28（84.85） B组 37 4 3 2 1 10（27.02） 29 29（78.38） χ2 2.422 0.483 P 0.12 0.487
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