The Detection Rate of Musculoskeletal Ultrasound in Patients with Rheumatic Knee Arthritis and Its Correlation with Knee Function
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摘要:
目的 探讨肌骨超声检查在风湿性膝关节炎患者中检出率及与膝关节功能的相关性。 方法 选择2019年5月1日至2020年3月1日风湿性膝关节炎患者(均为单膝患者)118例为对象;所有患者均经临床表现结合X线检查确诊;确诊前患者均拟行肌骨超声检查,并将肌骨超声检查结果与X线检查结果进行比较,分析肌骨超声在风湿性膝关节炎患者中的检出率;采用Lysholm评分法对患者患侧肢与健侧肢膝关节功能进行评估;采用Pearson相关性分析软件对肌骨超声检查结果与膝关节功能进行相关性分析。 结果 肌骨超声检查显示滑膜增厚、关节软骨退变、髌上囊积液、内侧半月板损伤退变、腘窝囊肿、韧带损伤、软骨下骨破坏检出率高于X线(P < 0.05);软骨下骨破坏、关节间隙变窄、骨质疏松、骨质增生检出率低于X线(P < 0.05);风湿性膝关节炎患者患侧膝关节跛行、承受能力、上下楼能力、下蹲起立、疼痛、关节肿痛及总分均低于健侧(P < 0.05);Pearson相关性分析,风湿性膝关节炎患者膝关节功能与滑膜增厚、关节软骨退变、髌上囊积液、内侧半月板损伤退变、腘窝囊肿、韧带损伤、软骨下骨破坏及骨质增生、关节间隙变窄呈负相关性(P < 0.05)。 结论 肌骨超声检查用于风湿性膝关节炎患者中能获得较高的检出率,且患者检出结果与膝关节功能存在一定相关性。 Abstract:Objective To investigate the detection rate of musculoskeletal ultrasonography in patients with rheumatic knee arthritis and its correlation with knee function. Methods A total of 118 patients with rheumatic knee arthritis (all patients with one knee affected) from May 1, 2019 to March 1, 2020 were selected as the subjects. All patients were confirmed by clinical manifestations combined with X-ray examination. Before diagnosis, all patients were planned to undergo musculoskeletal ultrasound examination, and the results of musculoskeletal ultrasound examination and X-ray examination were compared to analyze the detection rate of musculoskeletal ultrasound in patients with rheumatic knee arthritis. Lysholm score was used to evaluate the knee function of the affected and unaffected limbs. Pearson correlation analysis was used to analyze the correlation between musculoskeletal ultrasound results and knee function. Results The detection rate of synovium thickening, articular cartilage degeneration, suprapatellar sac effusion, medial meniscus injury and degeneration, popliteal cyst, ligament injury and subchondral bone destruction in musculoskeletal ultrasound was higher than that in X-ray (P < 0.05). The detection rates of subchondral bone destruction, joint space narrowing, osteoporosis and bone hyperplasia in musculoskeletal ultrasound were lower than those of X-ray (P < 0.05). The claudication, supporting, stair-climbing, squatting and standing up, pain, joint swelling and pain and total scores of the affected side of rheumatoid knee arthritis patients were lower than those of the healthy side (P < 0.05). Pearson correlation analysis results showed that knee function in patients with rheumatic knee arthritis was negatively correlated with synovial thickening, articular cartilage degeneration, suprapatellar sac effusion, medial meniscus injury and degeneration, popliteal fossa cyst, ligament injury, subchondral bone destruction and osteogenesis, and articular space narrowing (P < 0.05). Conclusion Musculoskeletal ultrasound has a high detection rate in patients with rheumatic knee arthritis, and there is correlation between the detection results and knee function. -
表 1 X线与肌骨超声在风湿性关节炎患者中病变类型检出率比较[n(%)]
Table 1. Comparison of X-ray and musculoskeletal ultrasound in the detection rate of disease types in patients with rheumatic arthritis [n (%)]
病变类型 肌骨超声检查(n = 118) X线检查(n = 118) t P 滑膜增厚 92(77.97) 0(0.00) 6.291 0.021* 关节软骨退变 94(79.66) 0(0.00) 5.534 0.035* 髌上囊积液 104(91.53) 0(0.00) 7.883 0.021* 关节间隙变窄 76(64.41) 95(80.51) 6.092 0.019* 内侧半月板损伤退变 45(38.14) 0(0.00) 6.734 0.018* 骨质疏松 0(0.00) 64(54.24) 7.143 0.016* 腘窝囊肿 51(45.76) 0(0.00) 5.892 0.021* 韧带损伤 16(13.56) 0(0.00) 6.546 0.016* 软骨下骨破坏 63(53.39) 18(15.25) 7.214 0.011* 骨质增生 59(50.00) 92(77.97) 5.993 0.023* *P < 0.05。 表 2 风湿性膝关节炎患者健侧与患侧膝关节功能比较[(
$\bar x \pm s $ )分]Table 2. Comparison of knee joint function between affected and unaffected side in patients with rheumatic arthritis [(
$\bar x \pm s $ )points]膝关节功能 患侧 健侧 t P 膝关节跛行 3.72 ± 0.32 4.23 ± 0.61 5.492 0.032* 承受能力 3.43 ± 0.26 3.76 ± 0.58 7.883 0.014* 上下楼能力 7.21 ± 0.84 7.71 ± 0.83 7.147 0.016* 下蹲起立 3.84 ± 0.47 4.87 ± 0.52 6.327 0.020* 疼痛 18.67 ± 3.23 21.67 ± 2.56 8.035 0.011* 关节肿痛 7.49 ± 1.42 7.99 ± 0.53 7.163 0.012* 总分 44.36 ± 5.93 50.23 ± 6.15 6.925 0.026* *P < 0.05。 表 3 肌骨超声检查与膝关节总分相关性(r,P)
Table 3. Correlation between musculoskeletal ultrasonography and total score of knee joint (r,P)
病变类型 r P 滑膜增厚 −0.784 0.021* 关节软骨退变 −0.851 0.015* 髌上囊积液 −0.745 0.018* 关节间隙变窄 −0.803 0.023* 内侧半月板损伤退变 −0.637 0.001* 骨质疏松 0.000 1.000 腘窝囊肿 −0.781 0.021* 韧带损伤 −0.833 0.025* 软骨下骨破坏 −0.675 0.021* 骨质增生 −0.782 0.018* *P < 0.05。 -
[1] 罗伟, 马丽辉, 邓黎黎, 等. IL-33和IL-17在类风湿性关节炎合并间质性肺病中的表达及临床意义[J]. 临床肺科杂志,2019,24(3):416-419. doi: 10.3969/j.issn.1009-6663.2019.03.008 [2] 邓秋萍, 莫巧璇, 简少珍, 等. 血清诱骗受体3γ-干扰素和抗环瓜氨酸肽抗体在风湿性关节炎患者中的表达及意义[J]. 河北医学,2019,25(4):699-702. doi: 10.3969/j.issn.1006-6233.2019.04.045 [3] Carstensen S M D, Terslev L, Jensen M P, et al. Future use of musculoskeletal ultrasonography and magnetic resonance imaging in rheumatoid arthritis[J]. Current Opinion in Rheumatology,2020,32(3):264-272. doi: 10.1097/BOR.0000000000000709 [4] 吴利, 袁斓, 兰颖. 针灸对类风湿性关节炎免疫功能影响的动物实验研究进展[J]. 现代临床医学,2015,41(5):326-328. doi: 10.11851/j.issn.1673-1557.2015.05.002 [5] 沈华良, 谭燕, 陈佳佳. 肌骨超声检查对血清阴性类风湿关节炎与骨关节炎的鉴别诊断价值[J]. 中国医刊,2019,54(5):565-567. doi: 10.3969/j.issn.1008-1070.2019.05.027 [6] 倪然, 陈睿, 余顺. 肌肉骨骼超声在痛风性关节炎不同时期检查中的应用[J]. 临床与病理杂志,2020,40(8):2138-2142. doi: 10.3978/j.issn.2095-6959.2020.08.034 [7] Jiang Z, Zhang H, Yu T, et al. Musculoskeletal ultrasonography combined with electromyography in the diagnosis of massage-inducted lateral plantar nerve injury: A case report[J]. Medicine,2020,99(28):e21130. doi: 10.1097/MD.0000000000021130 [8] 刘洁, 刘安, 陈世强. 肌骨超声在中老年退行性膝关节病变的临床应用价值[J]. 实用骨科杂志,2019,25(4):310-312. [9] 柏青, 王文己. 超声对老年类风湿性关节炎膝关节病变的诊断及疗效评估价值[J]. 临床超声医学杂志,2020,22(12):944-947. doi: 10.3969/j.issn.1008-6978.2020.12.024 [10] 芦海燕, 孟根其其格, 金月, 等. 超声引导联合神经刺激隐神经阻滞干预全膝关节置换术后患者的效果[J]. 中国介入影像与治疗学,2020,17(3):167-171. [11] Zabotti A, Sakellariou G, Tinazzi I, et al. Novel and reliable dactylitis global Sonographic (DACTOS) score in psoriatic arthritis[J]. Annals of the Rheumatic Diseases,2020,79(8):2020-217191. [12] 支海君, 郭晋平, 赵雅宁, 等. 床旁超声测量肢体骨骼肌厚度对ICU获得性肌无力的诊断价值[J]. 中华危重病急救医学,2020,32(4):494-497. doi: 10.3760/cma.j.cn121430-20200403-00084 [13] 宋佳, 孙磊, 刘焕, 等. 早期和非早期类风湿关节炎患者膝关节高频超声表现与多项血清学指标相关性研究[J]. 陕西医学杂志,2019,48(8):1006-1009. doi: 10.3969/j.issn.1000-7377.2019.08.013 [14] 莫建强, 陈康武, 仲冬艳, 等. 超声检查在早期膝关节骨关节炎诊断中的应用[J]. 山东医药,2019,59(15):64-66. doi: 10.3969/j.issn.1002-266X.2019.15.017 [15] 刘若实, 刘妍彤, 张杰. 基于肌骨超声的清痹颗粒外治膝骨关节炎(湿热痹阻证)临床疗效评价[J]. 辽宁中医杂志,2020,47(11):97-100. [16] 么纯, 王树东, 林星星. 肌骨超声对针刀治疗膝关节骨性关节炎的疗效评价[J]. 西部医学,2019,31(4):595-598+603. [17] Otsuka M, Koga T, Sumiyoshi R, et al. Rheumatoid arthritis-like active synovitis with T-cell activation in a case of idiopathic multicentric Castleman disease: A case report[J]. Medicine,2019,98(18):e15237. doi: 10.1097/MD.0000000000015237