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前列腺素E2对骨改建作用的研究进展

刘芸,  和红兵

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文章导航 > 昆明医科大学学报  > 2021 >  42(9): 149-155
刘芸, 和红兵. 前列腺素E2对骨改建作用的研究进展[J]. 昆明医科大学学报, 2021, 42(9): 149-155. doi: 10.12259/j.issn.2095-610X.S20210916
引用本文: 刘芸, 和红兵. 前列腺素E2对骨改建作用的研究进展[J]. 昆明医科大学学报, 2021, 42(9): 149-155. doi: 10.12259/j.issn.2095-610X.S20210916
shu
Yun LIU, Hong-bing HE. The Research Progress on the Effect of Prostaglandin E2 on Bone Remodeling[J]. Journal of Kunming Medical University, 2021, 42(9): 149-155. doi: 10.12259/j.issn.2095-610X.S20210916
Citation: Yun LIU, Hong-bing HE. The Research Progress on the Effect of Prostaglandin E2 on Bone Remodeling[J]. Journal of Kunming Medical University, 2021, 42(9): 149-155. doi: 10.12259/j.issn.2095-610X.S20210916
shu

前列腺素E2对骨改建作用的研究进展

doi: 10.12259/j.issn.2095-610X.S20210916

  • 昆明医科大学附属口腔医院牙周病科 云南 昆明　650500

基金项目: 国家自然科学基金资助项目（81660184）
详细信息
    作者简介:

    刘芸（1993～），女，云南昭通人，在读硕士研究生，主要从事牙周病临床工作

    通讯作者:

    和红兵，E-mail：1320058043@qq.com

  • 中图分类号: R781.4

The Research Progress on the Effect of Prostaglandin E2 on Bone Remodeling

  • Dept. of Periodontitis，The Affiliated Stomatological Hospital of Kunming Medical University，Kunming Yunnan 650500，China

    摘要
  • 摘要: 脂质介质对炎症性骨疾病如类风湿性关节炎、骨关节炎、牙周炎等疾病具有重要影响作用。其中前列腺素E2（prostaglandin E2，PGE2），它是骨改建过程中最重要的脂质介质之一，其对成骨细胞和破骨细胞均发挥显著的调控作用，并参与多种炎症性骨疾病的发生发展。PGE2在骨改建中的多面性使得较难辨别其作用。因此，就近年来关于PGE2在骨改建及炎症性骨疾病中的作用作一综述。
    Abstract: Lipid mediators have an important effect on inflammatory bone diseases such as rheumatoid arthritis, osteoarthritis, periodontitis, etc. Among them, PGE2, which is one of the most important lipid mediators in the process of bone remodeling, plays a significant regulatory role on both osteoblasts and osteoclasts, and participates in the occurrence and development of a variety of inflammatory bone diseases. PGE2 can mobilize cAMP and RANKL to promote osteoclast formation and increase bone resorption. Furthermore, interleukin （IL）-1- and IL-6-stimulated bone resorption involves PGE2 production. In addition to its bone-resorptive effffects, PGE2 promotes the bone formation in vitro by stimulating osteoblastic proliferation and difffferentiation. The multi-faceted nature of PGE2 makes it difficult to discern its role in bone remodeling. This article reviews the role of PGE2 in bone reconstruction in recent years.
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  • 收稿日期:  2021-06-14
  • 网络出版日期:  2021-09-13
  • 刊出日期:  2021-09-30

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