留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

外源性应用多肽分子防治缺血性脑卒中损伤的研究进展

尹赛格,  孙俊,  杨新旺

downloadPDF
文章导航 > 昆明医科大学学报  > 2021 >  42(9): 156-161
尹赛格, 孙俊, 杨新旺. 外源性应用多肽分子防治缺血性脑卒中损伤的研究进展[J]. 昆明医科大学学报, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929
引用本文: 尹赛格, 孙俊, 杨新旺. 外源性应用多肽分子防治缺血性脑卒中损伤的研究进展[J]. 昆明医科大学学报, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929
shu
Sai-ge YIN, Jun SUN, Xin-wang YANG. Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury[J]. Journal of Kunming Medical University, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929
Citation: Sai-ge YIN, Jun SUN, Xin-wang YANG. Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury[J]. Journal of Kunming Medical University, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929
shu

外源性应用多肽分子防治缺血性脑卒中损伤的研究进展

doi: 10.12259/j.issn.2095-610X.S20210929

  • 昆明医科大学基础医学院人体解剖与组织胚胎系，云南 昆明　650500

基金项目: 国家自然科学基金资助项目（81760648）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2018FE001（-161）]
详细信息
    作者简介:

    尹赛格（1992～），女，黑龙江哈尔滨人，医学博士，讲师，主要从事肽类分子探针与人类疾病研究工作

    通讯作者:

    孙俊，E-mail：sunjun6661@126.com

    杨新旺，E-mail：yangxinwanghp@163.com

  • 中图分类号: R741

Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury

  • Dept. of Anatomy and Histology & Embryology，Faculty of Basic Medical Science， Kunming Medical University，Kunming Yunnan 650500，China

    摘要
  • 摘要: 缺血性中风（ischemic stroke，IS）因其高发病率、高死亡率、高致残率和高复发率的特点成为目前导致长期、严重残疾的主要原因之一。目前临床上对于IS的治疗仅有唯一被批准使用的重组组织型纤维蛋白酶原激活剂，但因其时间窗较窄并有许多相对禁忌症包括使临床用药受到很大的限制。所以，开发新型高效的IS神经保护类药物具有重要的临床意义。近年来多肽类药物由于其低毒性、高靶向性和特异性的特点受到广泛关注，外源性应用多肽类药物对IS的防治作用也被报道。本文通过综述多种类型的多肽类药物对IS的防治作用及机制，为新型高效的IS神经保护类药物的开发提供新的分子与研究思路。
    Abstract: Ischemic stroke （IS） is one of the main causes of long-term and severe disability due to its high incidence rate, mortality rate, disability rate, and recurrence rate. At present, there is only the only approved recombinant tissue-type plasminogen activator for the treatment of is in the clinic. However, due to its narrow time window and many relative contraindications, the clinical medication is greatly limited. Therefore, the development of new and efficient is neuroprotective drugs has important clinical significance. In recent years, peptide molecular have attracted extensive attention due to their low toxicity, high targeting, and specificity. The prevention and treatment effect of exogenous peptide molecular on IS has also been reported. In this paper, we reviewed the preventive and therapeutic effects and mechanisms of various peptide molecule on IS and provided new molecular biological templates and research ideas for the development of new and efficient neuroprotective drugs for IS.
    • HTML全文
    • 参考文献(41)
  • [1] Zhou M,Wang H,Zeng X,et al. Mortality,morbidity,and risk factors in China and its provinces,1990-2017:A systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet,2019,394(10204):1145-1158.
    [2] Meng X,Xie W,Xu Q,et al. Neuroprotective effects of radix scrophulariae on cerebral ischemia and reperfusion injury via MAPK pathways[J]. Molecules,2018,23(9):2401.
    [3] Carmichael S T,Kathirvel U B,Schweppe C A,et al. Molecular,cellular and functional events in axonal sprouting after stroke[J]. Exp Neurol,2017,287(Pt 3):384-394.
    [4] 马海燕,陈红华. 中风患者的病情观察及护理体会[J]. 中国中医急症,2004,13(10):708-709. doi: 10.3969/j.issn.1004-745X.2004.10.079
    [5] Barthels D,Das H. Current advances in ischemic stroke research and therapies[J]. Biochim Biophys Acta Mol Basis Dis,2020,1866(4):165260. doi: 10.1016/j.bbadis.2018.09.012
    [6] 朱延焱,黄绳武. 肽类药物国内外研究进展[J]. 中国药师,2008,11(7):796-799. doi: 10.3969/j.issn.1008-049X.2008.07.026
    [7] Yang X,Wang Y,Wu C,et al. Animal venom peptides as a treasure trove for new therapeutics against neurodegenerative disorders[J]. Curr Med Chem,2019,26(25):4749-4774. doi: 10.2174/0929867325666181031122438
    [8] 齐烨迪,苏慧,陈莉,等. 多肽类药物研究进展[J]. 福建分析测试,2018,27(1):23-29. doi: 10.3969/j.issn.1009-8143.2018.01.07
    [9] Shan Y,Tan S,Lin Y,et al. The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke[J]. J Neuroinflammation,2019,16(1):242. doi: 10.1186/s12974-019-1638-6
    [10] Chen F,Wang W,Ding H,et al. The glucagon-like peptide-1 receptor agonist exendin-4 ameliorates warfarin-associated hemorrhagic transformation after cerebral ischemia[J]. J Neuroinflammation,2016,13(1):204. doi: 10.1186/s12974-016-0661-0
    [11] Lee C H,Yan B,Yoo K Y,et al. Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist,exendin-4,in experimental transient cerebral ischemia[J]. J Neurosci Res,2011,89(7):1103-1113. doi: 10.1002/jnr.22596
    [12] Teramoto S,Miyamoto N,Yatomi K,et al. Exendin-4,a glucagon-like peptide-1 receptor agonist,provides neuroprotection in mice transient focal cerebral ischemia[J]. J Cereb Blood Flow Metab,2011,31(8):1696-1705. doi: 10.1038/jcbfm.2011.51
    [13] Chen Y,Zhang X,He J,et al. Delayed administration of the glucagon-like peptide 1 analog liraglutide promoting angiogenesis after focal cerebral ischemia in mice[J]. J Stroke Cerebrovasc Dis,2018,27(5):1318-1325. doi: 10.1016/j.jstrokecerebrovasdis.2017.12.015
    [14] Rizk N N,Rafols J A,DunbarU J C. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats:Effects of insulin and C-peptide[J]. Brain Res,2006,1096(1):204-212. doi: 10.1016/j.brainres.2006.04.060
    [15] Fukuoka S,Yeh H,Mandybur T I,et al. Effect of insulin on acute experimental cerebral ischemia in gerbils[J]. Stroke,1989,20(3):396-399. doi: 10.1161/01.STR.20.3.396
    [16] Xing P,Ma K,Wu J,et al. Protective effect of polysaccharide peptide on cerebral ischemia-reperfusion injury in rats[J]. Mol Med Rep,2018,18(6):5371-5378.
    [17] Wang J,Liu Y M,Cao W,et al. Anti-inflammation and antioxidant effect of cordymin,a peptide purified from the medicinal mushroom cordyceps sinensis,in middle cerebral artery occlusion-induced focal cerebral ischemia in rats[J]. Metab Brain Dis,2012,27(2):159-165. doi: 10.1007/s11011-012-9282-1
    [18] Liu Z,Li P,Zhao D,et al. Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats[J]. Behavioral and Brain Functions,2010,6(1):1-6. doi: 10.1186/1744-9081-6-1
    [19] 何春娇,程琼,丁斐. 牛膝多肽活性成分对大鼠短暂性脑缺血的保护作用[J]. 南通大学学报:医学版,2017,37(2):91-96.
    [20] Bai L,Shi W,Liu J,et al. Protective effect of pilose antler peptide on cerebral ischemia/reperfusion (I/R) injury through Nrf-2/OH-1/NF-kappaB pathway[J]. Int J Biol Macromol,2017,9(102):741-748. doi: 10.1016/j.ijbiomac.2017.04.091
    [21] Lv Z,Qiu L,Jia Z,et al. The activated beta-integrin (CgbetaV) enhances RGD-binding and phagocytic capabilities of hemocytes in Crassostrea gigas[J]. Fish Shellfish Immunol,2019,87(4):638-649. doi: 10.1016/j.fsi.2019.01.047
    [22] Qian L,Wang J,Jiang J,et al. rLj-RGD3,a novel recombinant toxin protein from lampetra japonica,protects against cerebral reperfusion injury following middle cerebral artery occlusion involving the integrin-PI3K/Akt pathway in rats[J]. Plos One,2016,11(10):e0165093.
    [23] Williams A J,Ling G,Berti R,et al. Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats[J]. Exp Brain Res,2003,153(1):16-26. doi: 10.1007/s00221-003-1566-6
    [24] Madden K P,Clark W M,Marcoux F W,et al. Treatment with conotoxin,an 'N-type' calcium channel blocker,in neuronal hypoxic-ischemic injury[J]. Brain Res,1990,537(1-2):256-262. doi: 10.1016/0006-8993(90)90366-J
    [25] Perez-Pinzon M A,Yenari M A,Sun G H,et al. SNX-111,a novel,presynaptic N-type calcium channel antagonist,is neuroprotective against focal cerebral ischemia in rabbits[J]. J Neurol Sci,1997,153(1):25-31. doi: 10.1016/S0022-510X(97)00196-2
    [26] Takizawa S,Matsushima K,Fujita H,et al. A selective N-type calcium channel antagonist reduces extracellular glutamate release and infarct volume in focal cerebral ischemia[J]. J Cereb Blood Flow Metab,1995,15(4):611-618. doi: 10.1038/jcbfm.1995.75
    [27] Zhao Q,Smith M L,Siesjo B K. The omega-conopeptide SNX-111,an N-type calcium channel blocker,dramatically ameliorates brain damage due to transient focal ischaemia[J]. Acta Physiol Scand,1994,150(4):459-461. doi: 10.1111/j.1748-1716.1994.tb09713.x
    [28] Tao J,Yin S,Song Y,et al. Novel scorpion venom peptide HsTx2 ameliorates cerebral ischemic brain injury in rats via the MAPK signaling pathway[J]. Biochem Biophys Res Commun,2021,534(1):442-449. doi: 10.1016/j.bbrc.2020.11.062
    [29] Wang T,Wang S W,Zhang Y,et al. Scorpion venom heat-resistant peptide (SVHRP) enhances neurogenesis and neurite outgrowth of immature neurons in adult mice by up-regulating brain-derived neurotrophic factor (BDNF)[J]. PLoS One,2014,9(10):e109977. doi: 10.1371/journal.pone.0109977
    [30] 孔质彬. 蛇毒小分子多肽对大鼠脑缺血再灌注后脑组织肿瘤坏死因子变化的影响[J]. 实用预防医学,2009,16(4):1052-1054. doi: 10.3969/j.issn.1006-3110.2009.04.023
    [31] Li T T,Fan M L,Hou S X,et al. A novel snake venom-derived GPIb antagonist,anfibatide,protects mice from acute experimental ischaemic stroke and reperfusion injury[J]. Br J Pharmacol,2015,172(15):3904-3116. doi: 10.1111/bph.13178
    [32] Mccarthy C A,Rash L D,Chassagnon I R,et al. PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a[J]. Neuropharmacology,2015,99(24):650-657. doi: 10.1016/j.neuropharm.2015.08.040
    [33] Chassagnon I R,Mccarthy C A,Chin Y K,et al. Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a[J]. Proc Natl Acad Sci U S A,2017,114(14):3750-3755. doi: 10.1073/pnas.1614728114
    [34] Pinheiro A C,Gomez R S,Massensini A R,et al. Neuroprotective effect on brain injury by neurotoxins from the spider Phoneutria nigriventer[J]. Neurochem Int,2006,49(5):543-547. doi: 10.1016/j.neuint.2006.04.009
    [35] Guatimosimc,Romano-Silvama,Cruz J S,et al. A toxin from the spider phoneutria nigriventer that blocks calcium channels coupled to exocytosis[J]. Br J Pharmacol,1997,122(3):591-597. doi: 10.1038/sj.bjp.0701381
    [36] MirandaI D M,Romano-Silvama,Kalapothakise,et al. Phoneutria nigriventer toxins block tityustoxin-induced calcium influx in synaptosomes[J]. Neuroreport,1998,9(7):1371-1373. doi: 10.1097/00001756-199805110-00022
    [37] Wang Y R,Liu R Y,Wang L C,et al. Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus of rat with global cerebral ischemia[J]. Toxicon,2007,50(8):1085-1094. doi: 10.1016/j.toxicon.2007.07.020
    [38] Yin S,Yang M,LI Y,et al. Peptide OM-LV20 exerts neuroprotective effects against cerebral ischemia/reperfusion injury in rats[J]. Biochem Biophys Res Commun,2020,537(Suppl1):36-42.
    [39] 沈若武. 扇贝多肽对大鼠脑缺血损伤的保护作用研究 [D]. 青岛: 青岛大学硕士学位论文, 2002.
    [40] 林明宝,万丽玲,丁亚思,等. 水蛭多肽对大鼠脑缺血-再灌注损伤的保护作用及其机制[J]. 南昌大学学报(医学版),2015,99(24):650-657.
    [41] 王希,武建卓,宋淑亮,等. 水蛭多肽对局灶大鼠脑缺血再灌注损伤保护作用[J]. 中国生化药物杂志,2010,31(1):42-44.
    • 相关文章(20)
  • [1] 梁国晶, 冀琨, 张恺纯, 张玉芳, 安晶, 张钰鸽, 文娟, 任海燕.  益生菌对脑缺血再灌注损伤大鼠Aβ表达的影响及神经元的保护作用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240506
    [2] 王海军, 邱良武, 习杨彦彬, 庞俊娣.  有氧运动干预慢性脑缺血学习记忆能力研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240328
    [3] 张成才, 宁蓉, 陈娜, 彭艺晨, 周丽, 杨晰宸, 卢静怡, 张彭跃, 李蕊.  正中神经电刺激对缺血性脑卒中大鼠突触可塑性的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231201
    [4] 唐菁, 黄俊超, 黄亚非, 耿明珠, 毛小琴, 普建平.  磷脂酶相关脂蛋白A2在冠心病患者服用他汀类药物时的应用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211205
    [5] 马润, 陈孝红, 沈秀芬, 陶淑.  Lp-PLA2检测对缺血性脑卒中辅助诊断的研究, 昆明医科大学学报.
    [6] 李玲, 张芳, 何小凤, 胡建蓉, 吴琼.  多学科团队合作模式在缺血性脑卒中患者出院准备度中的应用, 昆明医科大学学报.
    [7] 蒋昔琴, 周先举.  团队资源管理模式应用于急性缺血性脑卒中患者缩短DNT的作用, 昆明医科大学学报.
    [8] 李科兴, 邹奕, 张丽娇.  神经节苷脂在改善新生儿缺氧缺血性脑病脑血流及神经功能指标中的效果, 昆明医科大学学报.
    [9] 谢姝姮.  小鼠缺血性脑卒中后免疫抑制及其机制, 昆明医科大学学报.
    [10] 程波.  高压氧辅助治疗高原急性缺血性脑卒中的效果, 昆明医科大学学报.
    [11] 于洋.  神经生长因子NGF的神经元保护作用机制及临床应用研究现状, 昆明医科大学学报.
    [12] 李东波.  CT灌注技术在缺血性脑血管病血流重建手术中的应用研究, 昆明医科大学学报.
    [13] 龙发青.  急性缺血性脑卒中就诊时间及其影响因素分析, 昆明医科大学学报.
    [14] 王志敏.  无瓣膜病变心房纤颤患者缺血性脑卒中相关因素研究, 昆明医科大学学报.
    [15] 孟丽红.  疏血通注射液治疗缺血性中风的临床研究, 昆明医科大学学报.
    [16] 杨立新.  超急性期缺血性脑卒中初诊NECT表现, 昆明医科大学学报.
    [17] 高虹.  DFY定量分析在新生儿缺氧缺血性脑病中的应用价值, 昆明医科大学学报.
    [18] .  上消化道出血伴发缺血性心肌损伤113例临床分析, 昆明医科大学学报.
    [19] 彭国晖.  CT灌注成像对急性缺血性脑病的诊断研究, 昆明医科大学学报.
    [20] 郭立民.  前臂缺血性肌挛缩术后复发2例报道, 昆明医科大学学报.
    • 施引文献
  • 资源附件(0)
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  2894
  • HTML全文浏览量:  2157
  • PDF下载量:  33
  • 被引次数: 0
出版历程
  • 收稿日期:  2021-06-13
  • 网络出版日期:  2021-09-28
  • 刊出日期:  2021-09-30

目录

    /

    返回文章
    返回

    版权所有 © 《昆明医科大学学报》编辑部  滇ICP备00000000号-0

    编辑出版：昆明医科大学学报编辑部

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计