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外源性应用多肽分子防治缺血性脑卒中损伤的研究进展

尹赛格 孙俊 杨新旺

尹赛格, 孙俊, 杨新旺. 外源性应用多肽分子防治缺血性脑卒中损伤的研究进展[J]. 昆明医科大学学报, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929
引用本文: 尹赛格, 孙俊, 杨新旺. 外源性应用多肽分子防治缺血性脑卒中损伤的研究进展[J]. 昆明医科大学学报, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929
Sai-ge YIN, Jun SUN, Xin-wang YANG. Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury[J]. Journal of Kunming Medical University, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929
Citation: Sai-ge YIN, Jun SUN, Xin-wang YANG. Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury[J]. Journal of Kunming Medical University, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929

外源性应用多肽分子防治缺血性脑卒中损伤的研究进展

doi: 10.12259/j.issn.2095-610X.S20210929
基金项目: 国家自然科学基金资助项目(81760648);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2018FE001(-161)]
详细信息
    作者简介:

    尹赛格(1992~),女,黑龙江哈尔滨人,医学博士,讲师,主要从事肽类分子探针与人类疾病研究工作

    通讯作者:

    孙俊,E-mail:sunjun6661@126.com

    杨新旺,E-mail:yangxinwanghp@163.com

  • 中图分类号: R741

Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury

  • 摘要: 缺血性中风(ischemic stroke,IS)因其高发病率、高死亡率、高致残率和高复发率的特点成为目前导致长期、严重残疾的主要原因之一。目前临床上对于IS的治疗仅有唯一被批准使用的重组组织型纤维蛋白酶原激活剂,但因其时间窗较窄并有许多相对禁忌症包括使临床用药受到很大的限制。所以,开发新型高效的IS神经保护类药物具有重要的临床意义。近年来多肽类药物由于其低毒性、高靶向性和特异性的特点受到广泛关注,外源性应用多肽类药物对IS的防治作用也被报道。本文通过综述多种类型的多肽类药物对IS的防治作用及机制,为新型高效的IS神经保护类药物的开发提供新的分子与研究思路。
  • [1] Zhou M,Wang H,Zeng X,et al. Mortality,morbidity,and risk factors in China and its provinces,1990-2017:A systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet,2019,394(10204):1145-1158.
    [2] Meng X,Xie W,Xu Q,et al. Neuroprotective effects of radix scrophulariae on cerebral ischemia and reperfusion injury via MAPK pathways[J]. Molecules,2018,23(9):2401.
    [3] Carmichael S T,Kathirvel U B,Schweppe C A,et al. Molecular,cellular and functional events in axonal sprouting after stroke[J]. Exp Neurol,2017,287(Pt 3):384-394.
    [4] 马海燕,陈红华. 中风患者的病情观察及护理体会[J]. 中国中医急症,2004,13(10):708-709. doi: 10.3969/j.issn.1004-745X.2004.10.079
    [5] Barthels D,Das H. Current advances in ischemic stroke research and therapies[J]. Biochim Biophys Acta Mol Basis Dis,2020,1866(4):165260. doi: 10.1016/j.bbadis.2018.09.012
    [6] 朱延焱,黄绳武. 肽类药物国内外研究进展[J]. 中国药师,2008,11(7):796-799. doi: 10.3969/j.issn.1008-049X.2008.07.026
    [7] Yang X,Wang Y,Wu C,et al. Animal venom peptides as a treasure trove for new therapeutics against neurodegenerative disorders[J]. Curr Med Chem,2019,26(25):4749-4774. doi: 10.2174/0929867325666181031122438
    [8] 齐烨迪,苏慧,陈莉,等. 多肽类药物研究进展[J]. 福建分析测试,2018,27(1):23-29. doi: 10.3969/j.issn.1009-8143.2018.01.07
    [9] Shan Y,Tan S,Lin Y,et al. The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke[J]. J Neuroinflammation,2019,16(1):242. doi: 10.1186/s12974-019-1638-6
    [10] Chen F,Wang W,Ding H,et al. The glucagon-like peptide-1 receptor agonist exendin-4 ameliorates warfarin-associated hemorrhagic transformation after cerebral ischemia[J]. J Neuroinflammation,2016,13(1):204. doi: 10.1186/s12974-016-0661-0
    [11] Lee C H,Yan B,Yoo K Y,et al. Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist,exendin-4,in experimental transient cerebral ischemia[J]. J Neurosci Res,2011,89(7):1103-1113. doi: 10.1002/jnr.22596
    [12] Teramoto S,Miyamoto N,Yatomi K,et al. Exendin-4,a glucagon-like peptide-1 receptor agonist,provides neuroprotection in mice transient focal cerebral ischemia[J]. J Cereb Blood Flow Metab,2011,31(8):1696-1705. doi: 10.1038/jcbfm.2011.51
    [13] Chen Y,Zhang X,He J,et al. Delayed administration of the glucagon-like peptide 1 analog liraglutide promoting angiogenesis after focal cerebral ischemia in mice[J]. J Stroke Cerebrovasc Dis,2018,27(5):1318-1325. doi: 10.1016/j.jstrokecerebrovasdis.2017.12.015
    [14] Rizk N N,Rafols J A,DunbarU J C. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats:Effects of insulin and C-peptide[J]. Brain Res,2006,1096(1):204-212. doi: 10.1016/j.brainres.2006.04.060
    [15] Fukuoka S,Yeh H,Mandybur T I,et al. Effect of insulin on acute experimental cerebral ischemia in gerbils[J]. Stroke,1989,20(3):396-399. doi: 10.1161/01.STR.20.3.396
    [16] Xing P,Ma K,Wu J,et al. Protective effect of polysaccharide peptide on cerebral ischemia-reperfusion injury in rats[J]. Mol Med Rep,2018,18(6):5371-5378.
    [17] Wang J,Liu Y M,Cao W,et al. Anti-inflammation and antioxidant effect of cordymin,a peptide purified from the medicinal mushroom cordyceps sinensis,in middle cerebral artery occlusion-induced focal cerebral ischemia in rats[J]. Metab Brain Dis,2012,27(2):159-165. doi: 10.1007/s11011-012-9282-1
    [18] Liu Z,Li P,Zhao D,et al. Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats[J]. Behavioral and Brain Functions,2010,6(1):1-6. doi: 10.1186/1744-9081-6-1
    [19] 何春娇,程琼,丁斐. 牛膝多肽活性成分对大鼠短暂性脑缺血的保护作用[J]. 南通大学学报:医学版,2017,37(2):91-96.
    [20] Bai L,Shi W,Liu J,et al. Protective effect of pilose antler peptide on cerebral ischemia/reperfusion (I/R) injury through Nrf-2/OH-1/NF-kappaB pathway[J]. Int J Biol Macromol,2017,9(102):741-748. doi: 10.1016/j.ijbiomac.2017.04.091
    [21] Lv Z,Qiu L,Jia Z,et al. The activated beta-integrin (CgbetaV) enhances RGD-binding and phagocytic capabilities of hemocytes in Crassostrea gigas[J]. Fish Shellfish Immunol,2019,87(4):638-649. doi: 10.1016/j.fsi.2019.01.047
    [22] Qian L,Wang J,Jiang J,et al. rLj-RGD3,a novel recombinant toxin protein from lampetra japonica,protects against cerebral reperfusion injury following middle cerebral artery occlusion involving the integrin-PI3K/Akt pathway in rats[J]. Plos One,2016,11(10):e0165093.
    [23] Williams A J,Ling G,Berti R,et al. Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats[J]. Exp Brain Res,2003,153(1):16-26. doi: 10.1007/s00221-003-1566-6
    [24] Madden K P,Clark W M,Marcoux F W,et al. Treatment with conotoxin,an 'N-type' calcium channel blocker,in neuronal hypoxic-ischemic injury[J]. Brain Res,1990,537(1-2):256-262. doi: 10.1016/0006-8993(90)90366-J
    [25] Perez-Pinzon M A,Yenari M A,Sun G H,et al. SNX-111,a novel,presynaptic N-type calcium channel antagonist,is neuroprotective against focal cerebral ischemia in rabbits[J]. J Neurol Sci,1997,153(1):25-31. doi: 10.1016/S0022-510X(97)00196-2
    [26] Takizawa S,Matsushima K,Fujita H,et al. A selective N-type calcium channel antagonist reduces extracellular glutamate release and infarct volume in focal cerebral ischemia[J]. J Cereb Blood Flow Metab,1995,15(4):611-618. doi: 10.1038/jcbfm.1995.75
    [27] Zhao Q,Smith M L,Siesjo B K. The omega-conopeptide SNX-111,an N-type calcium channel blocker,dramatically ameliorates brain damage due to transient focal ischaemia[J]. Acta Physiol Scand,1994,150(4):459-461. doi: 10.1111/j.1748-1716.1994.tb09713.x
    [28] Tao J,Yin S,Song Y,et al. Novel scorpion venom peptide HsTx2 ameliorates cerebral ischemic brain injury in rats via the MAPK signaling pathway[J]. Biochem Biophys Res Commun,2021,534(1):442-449. doi: 10.1016/j.bbrc.2020.11.062
    [29] Wang T,Wang S W,Zhang Y,et al. Scorpion venom heat-resistant peptide (SVHRP) enhances neurogenesis and neurite outgrowth of immature neurons in adult mice by up-regulating brain-derived neurotrophic factor (BDNF)[J]. PLoS One,2014,9(10):e109977. doi: 10.1371/journal.pone.0109977
    [30] 孔质彬. 蛇毒小分子多肽对大鼠脑缺血再灌注后脑组织肿瘤坏死因子变化的影响[J]. 实用预防医学,2009,16(4):1052-1054. doi: 10.3969/j.issn.1006-3110.2009.04.023
    [31] Li T T,Fan M L,Hou S X,et al. A novel snake venom-derived GPIb antagonist,anfibatide,protects mice from acute experimental ischaemic stroke and reperfusion injury[J]. Br J Pharmacol,2015,172(15):3904-3116. doi: 10.1111/bph.13178
    [32] Mccarthy C A,Rash L D,Chassagnon I R,et al. PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a[J]. Neuropharmacology,2015,99(24):650-657. doi: 10.1016/j.neuropharm.2015.08.040
    [33] Chassagnon I R,Mccarthy C A,Chin Y K,et al. Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a[J]. Proc Natl Acad Sci U S A,2017,114(14):3750-3755. doi: 10.1073/pnas.1614728114
    [34] Pinheiro A C,Gomez R S,Massensini A R,et al. Neuroprotective effect on brain injury by neurotoxins from the spider Phoneutria nigriventer[J]. Neurochem Int,2006,49(5):543-547. doi: 10.1016/j.neuint.2006.04.009
    [35] Guatimosimc,Romano-Silvama,Cruz J S,et al. A toxin from the spider phoneutria nigriventer that blocks calcium channels coupled to exocytosis[J]. Br J Pharmacol,1997,122(3):591-597. doi: 10.1038/sj.bjp.0701381
    [36] MirandaI D M,Romano-Silvama,Kalapothakise,et al. Phoneutria nigriventer toxins block tityustoxin-induced calcium influx in synaptosomes[J]. Neuroreport,1998,9(7):1371-1373. doi: 10.1097/00001756-199805110-00022
    [37] Wang Y R,Liu R Y,Wang L C,et al. Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus of rat with global cerebral ischemia[J]. Toxicon,2007,50(8):1085-1094. doi: 10.1016/j.toxicon.2007.07.020
    [38] Yin S,Yang M,LI Y,et al. Peptide OM-LV20 exerts neuroprotective effects against cerebral ischemia/reperfusion injury in rats[J]. Biochem Biophys Res Commun,2020,537(Suppl1):36-42.
    [39] 沈若武. 扇贝多肽对大鼠脑缺血损伤的保护作用研究 [D]. 青岛: 青岛大学硕士学位论文, 2002.
    [40] 林明宝,万丽玲,丁亚思,等. 水蛭多肽对大鼠脑缺血-再灌注损伤的保护作用及其机制[J]. 南昌大学学报(医学版),2015,99(24):650-657.
    [41] 王希,武建卓,宋淑亮,等. 水蛭多肽对局灶大鼠脑缺血再灌注损伤保护作用[J]. 中国生化药物杂志,2010,31(1):42-44.
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  • 收稿日期:  2021-06-13
  • 网络出版日期:  2021-09-28
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