Expression and Significance of CARP, Myo and α1-microglobulin in Serum of Patients with Acute Myocardial Infarction
-
摘要:
目的 探究CARP、Myo、α1-微球蛋白在急性心肌梗死患者血清中的表达及意义。 方法 选取2019年2月至2019年8月在东南大学附属中大医院接受治疗的急性心肌梗死患者65例为本研究AMI组，另选取同期于东南大学附属中大医院接受常规体检的健康志愿者65例为本研究对照组。使用酶联免疫吸附法（ELISA）对血清心锚重复蛋白（CARP）进行检测，化学发光免疫法检测Myo水平，免疫透射比浊法检测α1-微球蛋白、cTnI、hs-TNI水平。 结果 与对照组研究对象比较，AMI组患者血清CARP、肌红蛋白、α1-微球蛋白、cTnI、hs-TNI水平较高，差异具有统计学意义（P < 0.05）。CARP、Myo在急性心肌梗死中呈正相关（r = 0.399，P = 0.001）；CARP、α1-微球蛋白在急性心肌梗死中呈正相关（r = 0.446，P = 0.001）；Myo、α1-微球蛋白在急性心肌梗死中呈正相关（r = 0.463，P = 0.001）。CARP、Myo、α1-微球蛋白与cTnI、hs-TNI水平均呈正相关（P < 0.05）。 结论 CARP、Myo、α1-微球蛋白在急性心肌梗死中水平异常升高，与cTnI、hs-TNI水平具有一定相关性，检测CARP、Myo、α1-微球蛋白水平能为急性心肌梗死患者早期的诊断、治疗及预后提供重要的参考依据，具有一定的临床价值。 Abstract:Objective To explore the expression and significance of CARP, Myo and α 1-microglobulin in serum of patients with acute myocardial infarction. Methods From February 2019 to August 2019, 65 patients with acute myocardial infarction who were treated in our hospital were selected as the AMI group of this study, and 65 healthy volunteers who received routine physical examination in our hospital at the same time were selected as the control group of this study. Serum cardiac anchor repeat protein （CARP） was detected by enzyme-linked immunosorbent assay （ELISA）, Myo level by chemiluminescent immunoassay, α1-microglobulin, cTnI, HS-TnI level by immunoturbidimetry. Results Compared with the control group, the levels of serum CARP, myoglobin, α1-microglobulin, cTnI and HS-TnI in AMI group were higher, the difference was statistically significant （P<0.05）. CARP and Myo were positively correlated in AMI （r = 0.399, P = 0.001）; CARP and α1-microglobulin were positively correlated in AMI （r = 0.446, P = 0.001）; Myo and α1-microglobulin were positively correlated in AMI （r = 0.463, P = 0.001）. There was a positive correlation between the levels of cTnI and HS-TnI. Conclusions The levels of CARP, Myo and α1-microglobulin are abnormally increased in acute myocardial infarction, which has a certain correlation with the levels of cTnI and HS-TnI. The detection of CARP, Myo and α1-microglobulin can provide an important reference for the early diagnosis, treatment and prognosis of patients with acute myocardial infarction, and has a certain clinical value. -
Key words:
- Anchor repeat protein /
- Myoglobin /
- α1-microglobulin /
- Acute myocardial infarction
-
图 1 CARP、Myo、α1-微球蛋白在急性心肌梗死中的相关性
A：CARP与Myo水平的相关性；B：CARP与α1-微球蛋白水平的相关性；C：Myo与α1-微球蛋白水平的相关性。
Figure 1. car, myo α Correlation of 1-microglobulin in acute myocardial infarction
表 1 2组研究对象血清CARP、肌红蛋白、α1-微球蛋白水平比较（
$ \bar x \pm s $ ）Table 1. Comparison of Serum carp, myoglobin and α 1-microglobulin levels between 2 groups （
$ \bar x \pm s $ ）组别 n CARP（kU/L） 肌红蛋白（μg/L） α1-微球蛋白（mg/L） 急性心肌梗死组 65 1458.26 ± 298.35 179.68 ± 42.67 20.16 ± 4.13 对照组 65 1098.55 ± 221.62 21.08 ± 2.97 4.32 ± 1.08 t 7.803 29.890 29.920 P < 0.001* < 0.001* < 0.001* *P < 0.05。 
下载: 导出CSV
表 2 2组研究对象cTnI、hs-TNI水平比较（
$ \bar x \pm s $ ）Table 2. Comparison of cTnI and HS TnI levels between two groups （
$ \bar x \pm s $ ）组别 n cTnI（μg/L） hs-TNI（ng/mL） AMI组 65 4.69 ± 1.13 9.32 ± 2.13 对照组 65 0.89 ± 0.15 3.86 ± 0.97 t 26.880 18.810 P < 0.001* < 0.001* *P < 0.05。
下载: 导出CSV
表 3 CARP、Myo、α1-微球蛋白与cTnI、hs-TNI水平相关性
Table 3. Correlation between CARP, myo α 1-microglobulin and cTnI and hs-TNI levels
指标 cTnI hs-TNI CARP r = 0.360
P = 0.003*r = 0.384
P = 0.002*Myo r = 0.419
P = 0.001*r = 0.362
P = 0.003*α1-微球蛋白 r = 0.380
P = 0.002*r = 0.375
P = 0.002**P<0.05。
下载: 导出CSV
-
[1] 丁晓松,李虹伟. 急性心肌梗死合并高血糖的诊治[J]. 中国糖尿病杂志,2019,27(12):956-958. [2] 孙达,常静,林莉莉. 川芎嗪治疗急性心肌梗死大鼠的作用机制研究[J]. 中国临床药理学杂志,2019,35(24):3208-3212. [3] 孙润民,王琼英,齐苗苗,等. 急性心肌梗死后心力衰竭预测因素的研究进展[J]. 中华心血管病杂志,2019,47(11):923-926. [4] 黄玲芳,狄宁宁,周松. 替格瑞洛联合匹伐他汀治疗急性心肌梗死临床研究[J]. 中国药业,2020,29(1):83-86. [5] 龚艳君,霍勇. 急性ST段抬高型心肌梗死诊断和治疗指南(2019)解读[J]. 中国心血管病研究,2019,17(12):1057-1061. doi: 10.3969/j.issn.1672-5301.2019.12.001 [6] Sezai Y S,Kudret K,Murat A,et al. Electrocardiographic diagnosis of atrial infarction in patients with acute inferior ST-segment elevation myocardial infarction[J]. Clinical Cardiology,2018,41(7):237-243. [7] Martovytskyi D V,Shelest O M,et al. Effect of endostatin and insulin-like growth factor-1 on angiogenesis in patients with acute myocardial infarction with obesity under the influence of zofenopril[J]. Wiad Lek,2020,73(1):63-67. [8] 温志浩,卢健棋,潘朝锌,等. 益气活血通阳法不同配比对急性心肌梗死兔血管生成因子影响的研究[J]. 现代中西医结合杂志,2019,28(34):3768-3772,3806. [9] 孟萌,魏佳丽,潘红,等. 血清HMGB1、sTLT-1水平对经皮冠状动脉介入治疗急性心肌梗死患者预后的影响[J]. 中国现代医学杂志,2019,29(24):38-43. doi: 10.3969/j.issn.1005-8982.2019.24.007 [10] 李霖,刘劲,黄创,等. 急性心肌梗死后心室重构患者超敏C反应蛋白及胱抑素C检测的临床价值研究[J]. 河北医学,2019,25(12):2045-2049. [11] 张福伟,谢倩,陈漠水,等. 急性ST段抬高型心肌梗死患者血清心锚重复蛋白与高敏C反应蛋白、肌酸激酶同工酶、心肌肌钙蛋白I相关性研究[J]. 中华危重症医学杂志(电子版),2017,10(2):82-86. doi: 10.3877/cma.j.issn.1674-6880.2017.02.003 [12] 匡荣仁,原丽萍,贺献芝,等. 三七总皂苷联合胺碘酮对阵发性房颤左心房内径和心锚重复蛋白的影响[J]. 天津中医药,2018,35(8):573-575. [13] 陈铭,廖禹林. 心肌锚定重复蛋白与心力衰竭之间的关系[J]. 广东医学,2011,32(23):3139-3141. doi: 10.3969/j.issn.1001-9448.2011.23.048 [14] 郝欣阳,刘洪梅,袁梦,等. 冠心病合并糖尿病患者血清CARP水平与冠脉病变关系的研究[J]. 天津医科大学学报,2017,23(4):337-339. [15] 涂为民. 脑钠肽、肌红蛋白在慢性心力衰竭患者诊断中的临床价值[J]. 检验医学与临床,2019,16(21):3184-3186. doi: 10.3969/j.issn.1672-9455.2019.21.034 [16] 赵健红,丁阿凤. 心力衰竭患者血清心型脂肪酸结合蛋白肌钙蛋白T肌红蛋白N末端脑钠肽前体的检测及影响[J]. 山西医药杂志,2019,48(14):1699-1701. doi: 10.3969/j.issn.0253-9926.2019.14.022 [17] 林文利. 肌酸激酶血清肌红蛋白及炎症相关因子的动态监测在多发伤并发多器官功能障碍综合征诊断中的价值[J]. 山西医药杂志,2019,48(21):2594-2597. [18] 温志浩,卢健棋,潘朝锌,等. 益气活血通阳法不同配比对急性心肌梗死兔血管生成因子影响的研究[J]. 现代中西医结合杂志,2019,28(34):3768-3772,3806. [19] Hakuno D,Kimura M,Nakashima Y,et al. Hepatokine a1-microglobulin signaling alters macrophage polarization,exacerbates acute inflammation and adverse left ventricular remodeling in myocardial infarction[J]. Journal of the American College of Cardiology,2019,73(9):47. doi: 10.1016/S0735-1097(19)30656-4 [20] 黄静,黄志刚,黄亨建. 血清α1-微球蛋白、尿激肽原1联合检测在糖尿病肾病患者诊断中的临床价值[J]. 实用医院临床杂志,2019,16(6):12-15. doi: 10.3969/j.issn.1672-6170.2019.06.004 -
点击查看大图
图(1) / 表(3)
计量
- 文章访问数: 8085
- HTML全文浏览量: 5071
- PDF下载量: 37
- 被引次数: 0
