Correlation between Metabolic Syndrome and the Occurrence and Development of Gastric Cancer
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摘要: 胃癌是世界范围内发病率和死亡率均排行第二位的恶性肿瘤,严重威胁人类健康。近年,以胰岛素抵抗为核心的一组代谢紊乱症候群—代谢综合征 (metabolic syndrome,Mets) 与GC(gastric cancer,GC)的关系备受瞩目,大量研究表明Mets中各因素及其合并症均可以影响GC的发生、发展,可能机制包括高血糖、肥胖、胰岛素因子等单或多方面因素协同作用。旨在围绕近年相关研究,从流行病学、发病机制等方面综述MetS各项代谢相关因素及合并症与GC的关联。Abstract: Gastric cancer is the second most common malignant tumor in the world in terms of morbidity and mortality. It is a serious threat to human health.In recent years, with insulin resistance as the core of a group of metabolic disorder syndrome - the metabolic syndrome (metabolic syndrome, MetS) and the relationship between gastric cancer high-profile, a large number of studies had shown that various factors in the MetS and its complications could affect the occurrence and development of gastric cancer, the possible mechanism including hyperglycemia, obesity, insulin factors such as single or multiple factors synergy, this article aims to surrounding related research in recent years, were reviewed from aspects of the epidemiology, the pathogenesis of various metabolic factors associated with MetS and complications associated with stomach cancer.
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Key words:
- Gastric cancer /
- Metabolic syndrome /
- Obesity /
- Hyperlipidemia /
- Type 2 diabetes /
- Hypertension
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[1] 郑潇豪,解亦斌. 中国晚期胃癌的诊疗现状[J]. 癌症进展,2019,17(1):19-25+54. [2] Siegel R L,Miller K D,Jemal A. Cancer statistics,2020[J]. CA Cancer J Clin,2020,70(1):7-30. doi: 10.3322/caac.21590 [3] Liberda E N,Zuk A M,Martin I D,et al. Fisher's linear discriminant function analysis and its potential utility as a tool for the assessment of health-and-wellness programs in indigenous communities[J]. Int J Environ Res Public Health,2020,17(21):7894. doi: 10.3390/ijerph17217894 [4] Battelli M G,Bortolotti M,Polito L,et al. The role of xanthine oxidoreductase and uric acid in metabolic syndrome[J]. Biochim Biophys Acta Mol Basis Dis,2018,1864(8):2557-2565. doi: 10.1016/j.bbadis.2018.05.003 [5] Wang Z,Cai X J,Liu M J,et al. Age,gender and type 2 diabetes contribute to the risk of gastric cancer:a retrospective single institution analysis[J]. J Chin Pharm Sci,2014,23(11):799-803. [6] Bloomgarden Z. Diabetes and branched-chain amino acids:what is the link?[J]. J Diabetes,2018,10(5):350-352. doi: 10.1111/1753-0407.12645 [7] 陈燕. 肥胖预防与消化道肿瘤关系[J]. 心理医生,2017,23(30):329-330. [8] Shimada S,Sawada N,Ishiyama Y,et al. Impact of obesity on short- and long-term outcomes of laparoscopy assisted distal gastrectomy for gastric cancer[J]. Surg Endosc,2018,32(1):358-366. doi: 10.1007/s00464-017-5684-9 [9] Du X,Hidayat K,Shi B M. Abdominal obesity and gastroesophageal cancer risk:systematic review and meta-analysis of prospective studies[J]. Bioscience Reports,2017,37(3):BSR20160474. doi: 10.1042/BSR20160474 [10] Lin X H,Huang K H,Chuang W H,et al. The long term effect of metabolic profile and microbiota status in early gastric cancer patients after subtotal gastrectomy[J]. PLoS ONE,2018,13(11):e0206930. doi: 10.1371/journal.pone.0206930 [11] Kumar S,Metz D C,Ellenberg S,et al. Risk factors and incidence of gastric cancer after detection of helicobacter pylori Infection:a large cohort study[J]. Gastroenterology,2020,158(3):527-536. doi: 10.1053/j.gastro.2019.10.019 [12] 梁晓峰,李利娟,刘俊田. 代谢综合征与胃癌发病风险及临床病理特征相关性的研究[J]. 中国肿瘤临床,2019,46(19):986-993. doi: 10.3969/j.issn.1000-8179.2019.19.090 [13] 刘兆喆,邱诗晴,郭放,等. 体质量指数对胃癌预后影响[J]. 临床军医杂志,2017,45(1):20-23. [14] 韩帮岭,汪亦民,薛英威. 体质指数与胃癌患者临床病理特征和预后的关系[J]. 中华肿瘤杂志,2019,41(7):527-532. [15] Zhang D,Ku J,Yi Y,et al. The prognostic values of estrogen receptor alpha and beta in patients with gastroesophageal cancer:A meta-analysis[J]. Medicine (Baltimore),2019,98(46):e17954. [16] 李明晖,武雪亮,王立坤,等. 某院结直肠肿瘤患者围术期营养风险筛查与营养支持的现状分析[J]. 重庆医学,2020,49(12):1919-1922. doi: 10.3969/j.issn.1671-8348.2020.12.006 [17] 马翠翠,李杨,庞向鹏,等. 胃癌,结直肠癌患者血清瘦素和脂联素变化及相关性分析[J]. 肿瘤代谢与营养电子杂志,2019,6(3):351-356. [18] Ghasemi A,Saeidi J,Azimi-Nejad M,et al. Leptin-induced signaling pathways in cancer cell migration and invasion[J]. Cell Oncol (Dordr),2019,42(3):243-260. doi: 10.1007/s13402-019-00428-0 [19] Liu H,Luo J,Guillory B,et al. Ghrelin ameliorates tumor-induced adipose tissue atrophy and inflammation via Ghrelin receptor-dependent and -independent pathways[J]. Oncotarget,2020,11(35):3286-3302. doi: 10.18632/oncotarget.27705 [20] 苑小星. 脂质代谢异常与恶性肿瘤相关性研究进展[J]. 中国基层医药,2020,27(18):2300-2304. doi: 10.3760/cma.j.issn.1008-6706.2020.18.030 [21] 孙大勇. 血脂及脂蛋白代谢改变在胃癌中的临床意义[J]. 健康大视野,2019,(18):2. doi: 10.3969/j.issn.1005-0019.2019.18.002 [22] Li T,Qian Y,Li H,et al. Combination of serum lipids and cancer antigens as a novel marker for colon cancer diagnosis[J]. Lipids Health Dis,2018,17(1):261. doi: 10.1186/s12944-018-0911-5 [23] Kwon H J,Park M I,Park S J,et al. Insulin resistance is associated with early gastric cancer:a prospective multicenter case control study[J]. Gut Liver,2019,13(2):154-160. doi: 10.5009/gnl17556 [24] Gupta A,Das A,Majumder K,et al. Obesity is independently associated with increased risk of hepatocellular cancer-related mortality:a systematic review and meta-analysis[J]. Am J Clin Oncol,2018,41(9):874-881. doi: 10.1097/COC.0000000000000388 [25] 那日苏,鲁秀玲. 胃癌患者血清中的细胞因子表达水平及血清APN、血脂检测的临床意义[J]. 世界最新医学信息文摘,2016,16(A0):161-162. [26] Tao S,Li L,Li L,et al. Understanding the gut-kidney axis among biopsy-proven diabetic nephropathy,type 2 diabetes mellitus and healthy controls:an analysis of the gut microbiota composition[J]. Acta Diabetol,2019,56(5):581-592. doi: 10.1007/s00592-019-01316-7 [27] Li Z B,Han H F,Chang Y. Association between metabolic syndrome and the incidence of gastric cancer:a meta-analysis of cohort studies[J]. Diabetol Metab Syndr,2019,11(1):83. [28] Zhou X P,Rong- Hai H E,Quan H. Clinical characteristics analysis of senile patients with type 2 diabetes mellitus complicated with gastroesophageal reflux disease[J]. China Practical Med,2015,21(4):425-428. [29] Li F,Du H,Li S,et al. The association between metabolic syndrome and gastric cance r in chinese[J]. Frontiers in Oncology,2018,8(23):326. [30] 张伟,黄少敏,黄炫杰,等. 2型糖尿病与消化系统恶性肿瘤的相关性分析[J]. 饮食保健,2018,5(50):34-35. doi: 10.3969/j.issn.2095-8439.2018.50.042 [31] Gu J,Yan S,Wang B,et al. Type 2 diabetes mellitus and risk of gallbladder cancer:a systematic review and meta-analysis of observational studies[J]. Diabetes Metab Res Rev,2016,32(1):63-72. doi: 10.1002/dmrr.2671 [32] 安运锋,李霞,向月应,等. 代谢综合征与恶性肿瘤相关性研究进展[J]. 肿瘤代谢与营养电子杂志,2017,4(3):343-348. [33] Lu J,Zheng C H,Cao L L,et al. The effectiveness of the 8th American Joint Committee on Cancer TNM classification in the prognosis evaluation of gastric cancer patients:A comparative study between the 7th and 8th editions[J]. Eur J Surg Oncol,2017,43(12):2349-2356. doi: 10.1016/j.ejso.2017.09.001 [34] Sun L,Zhou P,Hua Q,et al. Effects of blood glucose,blood lipids and blood pressure control on recovery of patients with gastric cancer complicated with metabolic syndrome after radical gastrectomy[J]. Exp Ther Med,2018,15(6):4785-4790. [35] 黄慧玲. 抗肿瘤治疗与高血压[J]. 中国医刊,2019,54(8):823-828. doi: 10.3969/j.issn.1008-1070.2019.08.004 [36] Dovell F,Boffetta P. Serum uric acid and cancer mortality and incidence:a systematic review and meta-analysis[J]. Eur J Cancer Prev,2018,27(4):399-405. doi: 10.1097/CEJ.0000000000000440 [37] 苑小星,杨海芳. 血清尿酸及C反应蛋白与恶性实体肿瘤临床分期的关系[J]. 浙江医学,2019,41(13):1891-1894. [38] 蒋传林,田山,董卫国. 高尿酸血症与胃癌预后关系的研究[J]. 实用癌症杂志,2019,34(2):207-210. doi: 10.3969/j.issn.1001-5930.2019.02.009 [39] Yang J,Wang Y,Zhao Q,et al. Association of serum uric acid with increased risk of cancer among hypertensive chinese[J]. Int J Cancer,2017,141(1):112-120. doi: 10.1002/ijc.30731 [40] 潘理会,李育庄,李春辉. 胃癌与高凝血状态关系的研究现状[J]. 医学信息,2018,31(11):15-17,27. doi: 10.3969/j.issn.1006-1959.2018.11.005
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