急性冠状动脉综合征患者早期冠状动脉病变的评估

赵娟; 涂腾灿; 杨梅君; 张小勇; 潘伟

doi:10.12259/j.issn.2095-610X.S20211219

急性冠状动脉综合征患者早期冠状动脉病变的评估

doi: 10.12259/j.issn.2095-610X.S20211219

赵娟¹,
涂腾灿²,
杨梅君³,
张小勇^4, ,,
潘伟^2, ,

1.
华南理工大学附属第六医院/南海区人民医院超声科
2.
心内科，广东佛山　528200
3.
临沧市人民医院药剂科，云南临沧　677000
4.
昆明医科大学附属延安医院心内科，云南昆明　650051

基金项目: 广东省自然科学基金资助项目（2015A030310068）；佛山市医学科技攻关基金资助项目（2020001004341）；佛山市杰出青年医学人才计划基金资助项目（201803）

详细信息

作者简介:
赵娟（1979～）女，湖北黄梅人，医学学士，副主任医师，主要从事心脏超声诊断工作

通讯作者:
张小勇，E-mail：zhangxykm@sohu.com

潘伟，E-mail：weipan1977@163.com

中图分类号: R543.3
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出版历程
- 收稿日期: 2021-09-05
- 网络出版日期: 2021-11-17
- 刊出日期: 2021-12-15

Assessment of Early Coronary Artery Disease in Patients with Acute Coronary Syndrome

1.
Dept. of Ultrasound
2.
Dept. of Cardiovascular，The 6th Affiliated Hospital，South China University of Technology，Nanhai People Hospital，Foshan Guangdong 528200
3.
Dept. of Pharmacy，Lincang People’s Hospital，Lincang Yunnan 677000
4.
Dept. of Cardiovascular，The Affiliated Yan’an Hospital of Kunming Medical University，Kunming Yunnan 650051，China

摘要

摘要: 目的探讨血浆miR-30a与冠状动脉血管内超声（IVUS）在急性冠状动脉综合征（ACS）患者早期冠状动脉病变评估中的作用。方法随机入选88例ACS患者，包括稳定性心绞痛组（SA组，42例）和ACS组（46例）。用IVUS检测斑块负荷和重构指数（RI），用Real-time PCR法检测血浆miR-30a的含量。研究ACS组斑块负荷、RI和血浆miR-30a的变化。用Pearson相关性分析斑块负荷、血浆miR-30a和RI的关系。结果与SA组比较，ACS组患者斑块负荷增加[（62.82±4.40）%比（68.32±4.59）%]；RI增加（0.90±0.03）比（1.15±0.05）；血浆miR-30a升高[（8.10±1.09）2^-ΔΔct*10⁴比（11.66±1.19）2^-ΔΔct*10⁴]（P < 0.05）。RI和斑块负荷（r = 0.482，P = 0.000）、血浆miR-30a水平（r = 0.817，P = 0.000）呈正相关。结论 ACS患者早期已发生冠状动脉正性重构，血浆miR-30a可以作为ACS早期冠状动脉病变的评估指标。
- 超声心动图 /
- 微RNAs /
- 急性冠状动脉综合征 /
- 血管重构
Abstract: Objective To investigate the role of plasma miR-30a and coronary intravascular ultrasound （IVUS） in the early assessment of coronary artery disease in patients with acute coronary syndrome （ACS）. Methods 88 ACS patients were randomly selected, including stable angina group （SA group, 42 cases） and ACS group （46 cases）. Plaque load and remodeling index （RI） were detected by IVUS, and plasma miR-30a was detected by real-time PCR. The changes of plaque load, RI and plasma miR-30a in ACS group were studied. The relationship between plaque load, plasma miR-30a and RI was analyzed by Pearson correlation. Plaque load and remodeling index （RI） were detected by IVUS, and plasma miR-30a was detected by real-time PCR. The changes of plaque load, RI and plasma miR-30a in ACS group were studied. The relationship between plaque load, plasma miR-30a and RI was analyzed by Pearson correlation. Results Compared with SA group, plaque load in ACS group was increased [ （62.82±4.40）% vs （68.32±4.59）%]; RI increased from （0.90±0.03） to （1.15±0.05）; plasma miR-30a[ （8.10±1.09）2^-ΔΔct*10⁴ vs （11.66±1.19）2^-ΔΔct*10⁴] increased. RI was positively correlated with plaque load （r = 0.482, P = 0.000） and plasma miR-30a level （r = 0.817, P = 0.000）. Conclusion Patients with ACS have early coronary artery positive remodeling, and plasma miR-30a can be used as an evaluation indicator of early ACS coronary artery disease.
- Echocardiography /
- microRNAs /
- Acute coronary syndrome /
- Vascular remodeling

HTML全文

图 1 斑块负荷与RI的相关性分析

Figure 1. Correlation of plaque load with RI

下载: 全尺寸图片幻灯片

图 2 血浆miR-30a与RI的相关性分析

Figure 2. Correlation of plasma miR-30a with RI

下载: 全尺寸图片幻灯片

表 1 2组临床基础资料（$ \bar x \pm s $）

Table 1. Clinical information of the patients （$ \bar x \pm s $）

组别	n	年龄（岁）	性别（男/女）	收缩压（mmHg）	舒张压（mmHg）	空腹血糖（mmol/L）	LDL-C （mmol/L）	血肌酐（μmol/L）
SA组	42	62.2 ± 12.4	22/20	126.8 ± 18.1	70.9 ± 11.3	5.2 ± 0.8	2.9 ± 0.5	81.2 ± 16.1
ACS组	46	63.1 ± 9.9^*	24/22^*	127.6 ± 20.6^*	72.6 ± 10.9^*	5.2 ± 1.0^*	2.7 ± 0.6^*	79.8 ± 15.3^*
与SA组相比，^*P > 0.05。

下载: 导出CSV

表 2 2组患者斑块负荷、RI和血浆miR-30a比较（$ \bar x \pm s $）

Table 2. Comparison of plaque load，RI and plasma miR-30a in 2 groups （$ \bar x \pm s $）

组别	n	斑块负荷（%）	RI	血浆miR-30a（2^−ΔΔct*10⁴）
SA组	42	62.82 ± 4.40	0.90 ± 0.03	8.10 ± 1.09
ACS组	46	68.32 ± 4.59^*	1.15 ± 0.05^*	11.66 ± 1.19^*
与SA组相比，^*P < 0.05。

下载: 导出CSV

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