FBP1在癌症中的研究进展

李晓涛; 王海峰; 王剑松

doi:10.12259/j.issn.2095-610X.S20211237

FBP1在癌症中的研究进展

doi: 10.12259/j.issn.2095-610X.S20211237

昆明医科大学第二附属医院泌尿外科/云南省泌尿系统疾病临床医学中心，云南昆明　650101

基金项目: 国家自然科学基金资助项目（81960322）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202001AY070001-214）；云南省教育科学研究基金资助项目（2020J0177）

详细信息

作者简介:
李晓涛（1987～），男，云南砚山人，在读博士研究生，主要从事膀胱肿瘤临床与基础研究工作

通讯作者:
王剑松，E-mail： jiansongwangkm@126.com

中图分类号: R73
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出版历程
- 收稿日期: 2021-09-15
- 刊出日期: 2021-12-25

Advances on FBP1’s Role in Malignant Tumors

Dept. of Urology，The 2nd Affiliated hospital of Kunming Medical University / Yunnan Urinary System Disease Clinical Medical Center，Kunming Yunnan 650101，China

摘要

摘要: FBP1作为糖异生过程的关键酶，控制糖异生的速率，催化1-6二磷酸果糖不可逆的水解成6-磷酸果糖和无机磷酸盐，从而能够控制糖异生速率，影响细胞糖酵解。近年来，其在癌症中的作用越来越受到重视。研究发现FBP1在多种肿瘤中表达异常，与肿瘤发生、发展及预后关系密切，这些结果对于肿瘤分子标记物、靶向药物研究、预后相关研究表现出良好的前景。
- FBP1 /
- 有氧糖酵解 /
- 瓦博格效应 /
- 癌症
Abstract: As a key enzyme in the process of gluconeogenesis, FBP1 controls the rate of gluconeogenesis and catalyzes the irreversible hydrolysis of fructose 1-6 diphosphate into fructose 6-phosphate and inorganic phosphate, thereby controlling the rate of gluconeogenesis and affecting cellular glycolysis. In recent years, its role in malignant tumors has attracted more and more attention. Studies have found that FBP1 is abnormally expressed in a variety of tumors and is closely related to tumor occurrence and prognosis. These results show a good prospect for tumor molecular markers, targeted drug research, and prognosis-related research.
- FBP1 /
- Aerobic glycolysis /
- Warburg effect /
- Cancer

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参考文献(36)

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