Studies on the Correlation between Serum Vitamin A, D and Lung Function in Infants with Asthmatic Pneumonia
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摘要:
目的 了解喘憋性肺炎婴幼儿发作期儿童的血清25羟维生素D[25 （OH） D]和维生素A水平，分析其与肺功能、血清Ig E之间的相关性，以进一步发现维生素A、D与婴幼儿喘憋性肺炎的关系。 方法 调查2020年1月至2021年6月昆明医科大学第二附属医院6月～3岁符合喘憋性肺炎诊断标准的56名婴幼儿和50名匹配的健康婴幼儿, 用酶联免疫法检查血清25 （OH） D和Ig E浓度, 用肺功能仪检测喘憋性婴幼儿患者的潮气量、呼吸频率、吸气时间、达峰时间和达峰容积。分析2组儿童血清25 （OH） D和维生素A含量差异, 及喘憋性肺炎组患儿血清25 （OH） D和维生素A水平与急性发作严重程度的相关性。 结果 喘憋性肺炎组患儿发作期婴幼儿血清25 （OH） D和维生素A浓度分别为 （18.26±6.64） ng/mL、 （0.20±0.09） ng/mL 显著低于对照组 （25.28±3.48） ng/mL, （0.58±0.12） ng/mL，差异均有统计学意义 （P < 0.01）。血清25 （OH） D水平与发作婴幼儿的潮气量、呼吸频率、吸气时间、达峰时间呈正相关 （r = 0.364、0.341、0.369和0.548） , 与Ig E之间呈负相关 （r = -0.549）。 结论 喘憋性肺炎组患儿存在维生素A、D缺乏, 血清维生素A、25 （OH） D与喘憋性肺炎的发作存在关联。 Abstract:Objective To understand the serum levels of 25-hydroxyvitamin D [25 （OH） D] and vitamin A in infants with asthmatic pneumonia during the onset of pneumonia, so as to analyze their correlation with lung function and serum Ig E and to further discover vitamin A and D relationship with infantile asthmatic pneumonia. Methods Fifty-six infants and 50 matched healthy infants and young children who met the diagnostic criteria for asthmatic pneumonia from June to 3 in the Second Affiliated Hospital of Kunming Medical University from 2020 to 2021 were investigated, and enzyme-linked immunoassay was used to check serum 25 （OH） D and Ig E concentration. A pulmonary function meter was used to detect the tidal volume、respiratory rate, Inspiratory time, up to the peak volume of infants with asthmatic infants and young children. The differences in serum 25 （OH） D and vitamin A levels between the two groups of children were analyzed, and the correlation between serum 25 （OH） D and vitamin A levels in children with asthmatic pneumonia and the severity of acute attacks was analyzed. Results The serum 25 （OH） D and vitamin A concentrations of infants and young children in the asthmatic pneumonia group were （18.26±6.64） ng/ml and （0.20±0.09） ng/ml, respectively, which were significantly lower than those of the control group （25.28±3.48） ng/ml, （0.58±0.12） ng/ml, the difference was statistically significant （P < 0.01）. Serum 25 （OH） D levels were positively correlated with the tidal volume, respiratory rate, Inspiratory time , up to the peak volume in infants with onset （r = 0.364, 0.341, 0.369 and 0.548）, and negatively correlated with Ig E （r = -0.549）. Conclusion Children in the asthmatic pneumonia group had vitamin A and D deficiency, and serum vitamin A, 25 （OH） D asthmatic pneumonia episodes were associated. -
Key words:
- Asthmatic pneumonia /
- Infants /
- Vitamin A; Vitamin D /
- Lung function
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表 1 观察组与对照组婴幼儿一般情况比较（
$\bar x \pm s $ ）Table 1. The general situation of infants in observation group and control group was compared （
$\bar x \pm s $ ）组别 n 年龄（月） 性别（n） 男 女 观察组 56 12.6 ± 5.3 30 26 对照组 50 14.5 ± 5.6 27 23 t/χ2 1.79 0.002 P 0.075 0.965 
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表 2 观察组与对照组婴幼儿血清25 (OH) D、维生素A和lg E水平情况
Table 2. Serum 25 (OH) D vitamin A and LG E levels in the observation group and the control group
指标 观察组（n = 56） 对照组（n = 50） t P 25 （OH） D（ng/mL） 18.26 ± 6.64 24.58±3.56 6.002 < 0.01 维生素A（mg/L） 0.20 ± 0.09 0.58 ± 0.12 18.56 < 0.01 lg E（U/mL） 152.36 ± 8.95 82.36 ± 8.64 40.86 < 0.01
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