锌指蛋白与肝细胞癌的研究进展

张恒; 张成; 廖伟然; 何宇涛; 章宇洋; 杜斌; 王琳

doi:10.12259/j.issn.2095-610X.S20220135

锌指蛋白与肝细胞癌的研究进展

doi: 10.12259/j.issn.2095-610X.S20220135

昆明医科大学第二附属医院肝胆外科二病区，云南昆明　650101

基金项目: 国家自然科学基金资助项目（ 81660399）；昆明医科大学研究生创新基金资助项目（ 2021S205）

详细信息

作者简介:
张恒（1995～），男，江西抚州人，在读硕士研究生，主要从事肝癌基础研究工作

通讯作者:
王琳，E-mail：wanglinfey@126.com

中图分类号: R735.5
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- 被引次数: 0
出版历程
- 收稿日期: 2021-12-11
- 网络出版日期: 2021-12-20
- 刊出日期: 2022-01-15

Research Progress of Zinc Finger Protein and Hepatocellular Carcinoma

The 2nd Ward of Hepatobiliary Surgery，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

摘要

摘要: 由于肝细胞癌的发生与发展机理复杂，目前还未充分揭示。作为人体基因组中规模最大的转录因子家族，锌指蛋白现已证实在包括肝癌在内的许多癌症中起到了关键性作用，现将对探讨锌指蛋白的构成、类型，以及在肝细胞癌中的作用机制方面进行综述。
- 锌指蛋白 /
- 肝癌 /
- 基因调控 /
- 转录因子
Abstract: Due to its complicated mechanism, the occurrence and development of hepatocellular carcinoma have not been fully revealed yet. As the largest transcription factor family in the human genome, zinc finger proteins have been confirmed to play a key role in many cancers, including liver cancer. The mechanism of action is reviewed in this article.
- Zinc finger protein /
- Liver cancer /
- Gene regulation /
- Transcription factor

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参考文献(44)

[1]	Xiang Q,Zhou D,He X,et al. The zinc finger protein GATA4 induces mesenchymal-to-epithelial transition and cellular senescence through the nuclear factor-κB pathway in hepatocellular carcinoma[J]. J Gastroenterol Hepatol,2019,34(12):2196-2205. doi: 10.1111/jgh.14684
[2]	He L,Fan X,Li Y,et al. Overexpression of zinc finger protein 384 (ZNF 384),a poor prognostic predictor,promotes cell growth by upregulating the expression of Cyclin D1 in hepatocellular carcinoma[J]. Cell Death Dis,2019,10(6):444. doi: 10.1038/s41419-019-1681-3
[3]	Chen G,Chen J,Qiao Y,et al. ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair[J]. Nucleic Acids Res,2018,46(3):1266-1279. doi: 10.1093/nar/gkx1258
[4]	Addison J B,Koontz C,Fugett J H,et al. KAP1 promotes proliferation and metastatic progression of breast cancer cells[J]. Cancer Res,2015,75(2):344-355. doi: 10.1158/0008-5472.CAN-14-1561
[5]	Liao S Y,Kuo I Y,Chen Y T,et al. AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression[J]. Oncogene,2019,38(41):6723-6736. doi: 10.1038/s41388-019-0928-x
[6]	Gao S,Hsieh C L,Zhou J,et al. Zinc finger 280B regulates sGCα1 and p53 in prostate cancer cells[J]. PLoS One,2013,8(11):e78766. doi: 10.1371/journal.pone.0078766
[7]	Liu Y,Huang W,Gao X,et al. Regulation between two alternative splicing isoforms ZNF148(FL) and ZNF148(ΔN),and their roles in the apoptosis and invasion of colorectal cancer[J]. Pathol Res Pract,2019,215(2):272-277. doi: 10.1016/j.prp.2018.10.036
[8]	Laity J H,Lee B M,Wright P E. Zinc finger proteins:New insights into structural and functional diversity[J]. Curr Opin Struct Biol,2001,11(1):39-46. doi: 10.1016/S0959-440X(00)00167-6
[9]	Krishna S S,Majumdar I,Grishin N V. Structural classification of zinc fingers:Survey and summary[J]. Nucleic Acids Res,2003,31(2):532-550. doi: 10.1093/nar/gkg161
[10]	Guan C,He L,Chang Z,et al. ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling[J]. Oncogene,2020,39(8):1665-1680. doi: 10.1038/s41388-019-1075-0
[11]	Wu D,Liu G,Liu Y,et al. Zinc finger protein 191 inhibits hepatocellular carcinoma metastasis through discs large 1-mediated yes-associated protein inactivation[J]. Hepatology,2016,64(4):1148-1162. doi: 10.1002/hep.28708
[12]	YAO Z,LUO J,HU K,et al. ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth,migration, and invasion but through different signaling pathways[J]. Mol Oncol,2017,11(4):422-437.
[13]	LIN J,TAN H,NIE Y,et al. Kr ü ppel-like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway[J]. Cancer Sci,2019,110(4):1220-1231.
[14]	SUN H,PENG Z,TANG H,et al. Loss of KLF4 and consequential downregulation of Smad7 exacerbate oncogenic TGF-β signaling in and promote progression of hepatocellular carcinoma[J]. Oncogene,2017,36(21):2957-2968.
[15]	ZHANG C,CAO P,YANG A,et al. Downregulation of ZC3H14 driven by chromosome 14q31 deletion promotes hepatocellular carcinoma progression by activating integrin signaling[J]. Carcinogenesis,2019,40(3):474-486.
[16]	Zhou C,Li N. Expression of ZNF207 in hepatocellular carcinoma and its significance[J]. Zhong Nan Da Xue Xue Bao Yi Xue Ban,2019,44(4):406-412.
[17]	Liang Y,Li Q,Chen K,et al. Zinc finger protein 307 functions as a tumor-suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma[J]. Oncol Rep,2017,38(4):2229-2236. doi: 10.3892/or.2017.5868
[18]	Yin L,Fang Z,Shen N J,et al. Downregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells[J]. Drug Des Devel Ther,2017,11(1):2841-2850.
[19]	Yan X,Wu J,Jiang Q,et al. CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis[J]. J Mol Cell Biol,2018,10(1):48-59. doi: 10.1093/jmcb/mjx042
[20]	Luk S T,Ng K Y,Zhou L,et al. Deficiency in embryonic stem cell marker reduced expression 1 activates mitogen-activated protein kinase kinase 6-dependent p38 mitogen-activated protein kinase signaling to drive hepatocarcinogenesis[J]. Hepatology,2020,72(1):183-197.
[21]	杨小昂,路浩,董学员,等. 正常和肿瘤组织中ZNF165 mRNA的表达及其自发性抗体检测[J]. 郑州大学学报(医学版),2007,42(4):641-645. doi: 10.3969/j.issn.1671-6825.2007.04.012
[22]	Wu Z,Ma H,Wang L,et al. Tumor suppressor ZHX2 inhibits NAFLD-HCC progression via blocking LPL-mediated lipid uptake[J]. Cell Death Differ,2020,27(5):1693-1708. doi: 10.1038/s41418-019-0453-z
[23]	Lin Q,Wu Z,Yue X,et al. ZHX2 restricts hepatocellular carcinoma by suppressing stem cell-like traits through KDM2A-mediated H3K36 demethylation[J]. EBioMedicine,2020,53(1):102676.
[24]	Zheng L,Xu M,Xu J,et al. ELF3 promotes epithelial-mesenchymal transition by protecting ZEB1 from miR-141-3p-mediated silencing in hepatocellular carcinoma[J]. Cell Death Dis,2018,9(3):387. doi: 10.1038/s41419-018-0399-y
[25]	Yu X,Lin Q,Wu Z,et al. ZHX2 inhibits SREBP1c-mediated de novo lipogenesis in hepatocellular carcinoma via miR-24-3p[J]. J Pathol,2020,252(4):358-370. doi: 10.1002/path.5530
[26]	Chen W,Wu J,Shi W,et al. PRRX1 deficiency induces mesenchymal-epithelial transition through PITX2/miR-200-dependent SLUG/CTNNB1 regulation in hepatocellular carcinoma[J]. Cancer Sci,2021,112(6):2158-2172. doi: 10.1111/cas.14853
[27]	姜业臻,李超,王宇峰,等. ZNF217在肝细胞癌中的表达及对肿瘤侵袭的影响[J]. 实用癌症杂志,2019,34(3):349-353. doi: 10.3969/j.issn.1001-5930.2019.03.001
[28]	Si W,Zhao Y,Zhou J,et al. The coordination between ZNF217 and LSD1 contributes to hepatocellular carcinoma progress and is negatively regulated by miR-101[J]. Exp Cell Res,2019,379(1):1-10. doi: 10.1016/j.yexcr.2019.03.017
[29]	Ma M,Zhou Y,Sun R,et al. STAT3 and AKT signaling pathways mediate oncogenic role of NRSF in hepatocellular carcinoma[J]. Acta Biochim Biophys Sin (Shanghai),2020,52(10):1063-1070. doi: 10.1093/abbs/gmaa069
[30]	Xie W,Qiao X,Shang L,et al. Knockdown of ZNF233 suppresses hepatocellular carcinoma cell proliferation and tumorigenesis[J]. Gene,2018,679(1):179-185.
[31]	Li Z,Li Z,Wang L,et al. ZCCHC13-mediated induction of human liver cancer is associated with the modulation of DNA methylation and the AKT/ERK signaling pathway[J]. J Transl Med,2019,17(1):108. doi: 10.1186/s12967-019-1852-0
[32]	Liu Y,Wu D,Cheng H,et al. Wnt8B,transcriptionally regulated by ZNF191,promotes cell proliferation of hepatocellular carcinoma via Wnt signaling[J]. Cancer Sci,2021,112(2):629-640. doi: 10.1111/cas.14738
[33]	Wang T,Wang X G,Xu J H,et al. Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathway[J]. J Cell Mol Med,2012,16(5):1134-1145. doi: 10.1111/j.1582-4934.2011.01388.x
[34]	Long Y,Marian T A,Wei Z. ZFR promotes cell proliferation and tumor development in colorectal and liver cancers[J]. Biochem Biophys Res Commun,2019,513(4):1027-1034. doi: 10.1016/j.bbrc.2019.04.103
[35]	Luo W,Zhu X,Liu W,et al. MYC associated zinc finger protein promotes the invasion and metastasis of hepatocellular carcinoma by inducing epithelial mesenchymal transition[J]. Oncotarget,2016,7(52):86420-86432. doi: 10.18632/oncotarget.13416
[36]	李静,王涛. ZNF300基因在肝癌耐药细胞HepG2/VCR中的表达及功能初探[J]. 中国药理学通报,2013,29(7):951-955. doi: 10.3969/j.issn.1001-1978.2013.07.015
[37]	闫春晓,武利萍,谭莉霞,等. 肝癌患者锌指蛋白281的表达水平及其对肝癌细胞增殖凋亡的影响[J]. 安徽医学,2019,40(6):613-617. doi: 10.3969/j.issn.1000-0399.2019.06.004
[38]	Karaosmanoğlu O,Banerjee S,Sivas H. Identification of biomarkers associated with partial epithelial to mesenchymal transition in the secretome of slug over-expressing hepatocellular carcinoma cells[J]. Cell Oncol (Dordr),2018,41(4):439-453. doi: 10.1007/s13402-018-0384-6
[39]	Wang C,Fu S Y,Wang M D,et al. Zinc finger protein X-linked promotes expansion of EpCAM(+) cancer stem-like cells in hepatocellular carcinoma[J]. Mol Oncol,2017,11(5):455-469. doi: 10.1002/1878-0261.12036
[40]	Fu C,An N,Liu J,et al. The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1α in liver cancer cells[J]. J Biol Chem,2020,295(20):7060-7074. doi: 10.1074/jbc.RA119.012131
[41]	Wang H,Xu H,Ma F,et al. Zinc finger protein 703 induces EMT and sorafenib resistance in hepatocellular carcinoma by transactivating CLDN4 expression[J]. Cell Death Dis,2020,11(4):225. doi: 10.1038/s41419-020-2422-3
[42]	Zhang L,Huo Q,Ge C,et al. ZNF143-mediated H3K9 trimethylation upregulates CDC6 by activating MDIG in hepatocellular carcinoma[J]. Cancer Res,2020,80(12):2599-2611. doi: 10.1158/0008-5472.CAN-19-3226
[43]	SUN W,ZHANG Y,WONG K C,et al. Increased expression of GATA zinc finger domain containing 1 through gene amplification promotes liver cancer by directly inducing phosphatase of regenerating liver 3[J]. Hepatology,2018,67(6):2302-2319.
[44]	彭宁,李绵靖,兰超智,等. 长链非编码RNA ZNF674-AS1通过Wnt信号通路调节肝癌细胞的增殖与凋亡[J]. 中华实验外科杂志,2019,36(2):308-311.

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