留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

嗜黏蛋白阿克曼菌与肥胖相关代谢性疾病的研究进展

周洪江,  唐娟,  梁磊,  念馨

downloadPDF
文章导航 > 昆明医科大学学报  > 2022 >  43(1): 157-162
周洪江, 唐娟, 梁磊, 念馨. 嗜黏蛋白阿克曼菌与肥胖相关代谢性疾病的研究进展[J]. 昆明医科大学学报, 2022, 43(1): 157-162. doi: 10.12259/j.issn.2095-610X.S20220143
引用本文: 周洪江, 唐娟, 梁磊, 念馨. 嗜黏蛋白阿克曼菌与肥胖相关代谢性疾病的研究进展[J]. 昆明医科大学学报, 2022, 43(1): 157-162. doi: 10.12259/j.issn.2095-610X.S20220143
shu
Hongjiang ZHOU, Juan TANG, Lei LIANG, Xin NIAN. Research Progress of Akkermansia Muciniphila and Obesity-related Metabolic Diseases[J]. Journal of Kunming Medical University, 2022, 43(1): 157-162. doi: 10.12259/j.issn.2095-610X.S20220143
Citation: Hongjiang ZHOU, Juan TANG, Lei LIANG, Xin NIAN. Research Progress of Akkermansia Muciniphila and Obesity-related Metabolic Diseases[J]. Journal of Kunming Medical University, 2022, 43(1): 157-162. doi: 10.12259/j.issn.2095-610X.S20220143
shu

嗜黏蛋白阿克曼菌与肥胖相关代谢性疾病的研究进展

doi: 10.12259/j.issn.2095-610X.S20220143

  • 昆明医科大学第一附属医院内分泌科，云南 昆明　650032

基金项目: 国家自然科学基金资助项目 （81660153）；云南省卫生和计划生育委员会医学学科带头人培养计划基金资助项目（D-2017041）
详细信息
    作者简介:

    周洪江 （1995～），女，云南大理人，在读硕士研究生，主要从事内分泌基础与临床研究工作。唐娟与周洪江对本文有同等贡献

    通讯作者:

    念馨，E-mail：nianxinkm@hotmail.com

  • 中图分类号: R589.2

Research Progress of Akkermansia Muciniphila and Obesity-related Metabolic Diseases

  • Dept. of Endocrinology，The 1st Affiliated Hospital of Kunming Medical University， Kunming Yunnan 650032，China

    摘要
  • 摘要: 肠道微生物群在调节宿主免疫和能量代谢等方面起着至关重要的作用，与肥胖、糖尿病以及心血管疾病等疾病的发生有关。目前，多种动物模型和人体研究证明，嗜黏蛋白阿克曼菌（Akkermansia muciniphila/A. muciniphila）水平与肥胖、糖尿病、肥胖性肝病、动脉粥样硬化等代谢性疾病的发生呈负相关。A. muciniphila通过增加肠道黏液层厚度、减轻全身炎症、改善糖耐量和胰岛素抵抗，在治疗代谢紊乱方面具有广阔前景，被认为是新一代的治疗药物。就A. muciniphila与代谢性疾病及宿主之间相互作用的基本机制作系统性综述。
    Abstract: The intestinal microbiota plays a vital role in regulating host immunity and energy metabolism, and is related to the occurrence of obesity, diabetes, and cardiovascular diseases. At present, various animal models and human studies have proved that Akkermansia muciniphila （Akkermansia muciniphila/A. muciniphila） levels are negatively correlated with the occurrence of metabolic diseases such as obesity, diabetes, obese liver disease, and atherosclerosis. A. muciniphila has broad prospects in the treatment of metabolic disorders by increasing the thickness of the intestinal mucus layer, reducing systemic inflammation, improving glucose tolerance and insulin resistance, and is considered to be a new generation of therapeutic drugs. This article systematically reviews the basic mechanism of the interaction between A. muciniphila and metabolic diseases and hosts.
    • HTML全文
    • 参考文献(45)
  • [1] Armet A M,Deehan E C,Thone J V,et al. The effect of isolated and synthetic dietary fibers on markers of metabolic diseases in human intervention studies:A systematic review[J]. Adv Nutr,2020,11(2):420-438.
    [2] Rothschild D,Weissbrod O,Barkan E,et al. Environment dominates over host genetics in shaping human gut microbiota[J]. Nature,2018,555(7695):210-215. doi: 10.1038/nature25973
    [3] Komaroff A L. The microbiome and risk for obesity and diabetes[J]. JAMA,2017,317(4):355-356. doi: 10.1001/jama.2016.20099
    [4] Zhai Q,Feng S,Arjan N,et al. A next generation probiotic,Akkermansia muciniphila[J]. Crit Rev Food Sci Nutr,2019,59(19):3227-3236. doi: 10.1080/10408398.2018.1517725
    [5] Cani P D,de Vos W M. Next-generation beneficial microbes:The case of Akkermansia muciniphila[J]. Front Microbiol,2017,8(1):e1765.
    [6] Derrien M, Vaughan E E, Plugge C M, et al. Akkermansia muciniphila gen. nov. , sp. nov. , a human intestinal mucin-degrading bacterium [J]. Int J Syst Evol Microbiol, 2004, 54（Pt 5）: 1469-1476.
    [7] Reunanen J,Kainulainen V,Huuskonen L,et al. Akkermansia muciniphila adheres to enterocytes and strengthens the integrity of the epithelial cell layer[J]. Appl Environ Microbiol,2015,81(11):3655-3662. doi: 10.1128/AEM.04050-14
    [8] Collado M C,Derrien M,Isolauri E,et al. Intestinal integrity and Akkermansia muciniphila,a mucin-degrading member of the intestinal microbiota present in infants,adults,and the elderly[J]. Appl Environ Microbiol,2007,73(23):7767-7770. doi: 10.1128/AEM.01477-07
    [9] Belzer C,de Vos W M. Microbes inside-from diversity to function:The case of Akkermansia[J]. ISME J,2012,6(8):1449-1458. doi: 10.1038/ismej.2012.6
    [10] Everard A,Belzer C,Geurts L,et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity[J]. Proc Natl Acad Sci USA,2013,110(22):9066-9071. doi: 10.1073/pnas.1219451110
    [11] Schneeberger M,Everard A,Gomez-Valades A G,et al. Akkermansia muciniphila inversely correlates with the onset of inflammation,altered adipose tissue metabolism and metabolic disorders during obesity in mice[J]. Sci Rep,2015,5(2):143-150.
    [12] Derrien M,Belzer C,de Vos W M. Akkermansia muciniphila and its role in regulating host functions[J]. Microb Pathog,2017,106(2):171-181.
    [13] Anhe F F,Nachbar R T,Varin T V,et al. Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice[J]. Gut,2019,68(3):453-464. doi: 10.1136/gutjnl-2017-315565
    [14] Gulhane M,Murray L,Lourie R,et al. High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22[J]. Sci Rep,2016,6(3):e28990.
    [15] Shih C T,Yeh Y T,Lin C C,et al. Akkermansia muciniphila is negatively correlated with Hemoglobin A1c in refractory diabetes[J]. Microorganisms,2020,8(9):1360-1372. doi: 10.3390/microorganisms8091360
    [16] Greer R L,Dong X,Moraes A C,et al. Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism[J]. Nat Commun,2016,7(1):129-136.
    [17] Dao M C,Everard A,Aron-Wisnewsky J,et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity:Relationship with gut microbiome richness and ecology[J]. Gut,2016,65(3):426-436. doi: 10.1136/gutjnl-2014-308778
    [18] Katiraei S,de Vries M R,Costain A H,et al. Akkermansia muciniphila exerts lipid-lowering and immunomodulatory effects without affecting neointima formation in hyperlipidemic APOE*3-Leiden. CETP mice[J]. Mol Nutr Food Res,2020,64(15):e1900732. doi: 10.1002/mnfr.201900732
    [19] Polyzos S A,Kountouras J,Mantzoros C S. Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics[J]. Metabolism,2019,92(3):82-97.
    [20] Juarez-Fernandez M,Porras D,Petrov P,et al. The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation[J]. Antioxidants,2021,10(12):126-151.
    [21] Shin N R,Lee J C,Lee H Y,et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice[J]. Gut,2014,63(5):727-735. doi: 10.1136/gutjnl-2012-303839
    [22] Van Passel M W,Kant R,Zoetendal E G,et al. The genome of Akkermansia muciniphila,a dedicated intestinal mucin degrader,and its use in exploring intestinal metagenomes[J]. PLoS One,2011,6(3):e16876. doi: 10.1371/journal.pone.0016876
    [23] Chelakkot C,Choi Y,Kim D K,et al. Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions[J]. Exp Mol Med,2018,50(2):e450. doi: 10.1038/emm.2017.282
    [24] Van der Lugt B,van Beek A A,Aalvink S,et al. Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 (-/Delta7) mice[J]. Immun Ageing,2019,16(1):6-23. doi: 10.1186/s12979-019-0145-z
    [25] Muccioli G G,Naslain D,Backhed F,et al. The endocannabinoid system links gut microbiota to adipogenesis[J]. Mol Syst Biol,2010,6(3):e392.
    [26] Alam A,Leoni G,Quiros M,et al. The microenvironment of injured murine gut elicits a local pro-restitutive microbiota[J]. Nat Microbiol,2016,1(2):e15021. doi: 10.1038/nmicrobiol.2015.21
    [27] Kim K A,Gu W,Lee I A,et al. High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway[J]. PLoS One,2012,7(10):e47713. doi: 10.1371/journal.pone.0047713
    [28] Kihl P,Krych L,Deng L,et al. Oral LPS dosing induces local immunological changes in the pancreatic lymph nodes in mice[J]. J Diabetes Res,2019,9(5):e1649279.
    [29] Plovier H,Everard A,Druart C,et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice[J]. Nat Med,2017,23(1):107-113. doi: 10.1038/nm.4236
    [30] England A,Valdes A M,Slater-Jefferies J L,et al. Variants in the genes encoding TNF-α,IL-10,and GSTP1 influence the effect of α-tocopherol on inflammatory cell responses in healthy men[J]. Am J Clin Nutr,2012,95(6):1461-1467. doi: 10.3945/ajcn.111.012781
    [31] Kim K A,Lee I A,Gu W,et al. β-Sitosterol attenuates high-fat diet-induced intestinal inflammation in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 in the NF-κB pathway[J]. Mol Nutr Food Res,2014,58(5):963-972. doi: 10.1002/mnfr.201300433
    [32] Fraile L,Crisci E,Cordoba L,et al. Immunomodulatory properties of β-sitosterol in pig immune responses[J]. Int Immunopharmacol,2012,13(3):316-321. doi: 10.1016/j.intimp.2012.04.017
    [33] Wu W,Lv L,Shi D,et al. Protective effect of Akkermansia muciniphila against immune-mediated liver injury in a mouse model[J]. Front Microbiol,2017,8(2):e1804.
    [34] Png C W,Linden S K,Gilshenan K S,et al. Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria[J]. Am J Gastroenterol,2010,105(11):2420-2428. doi: 10.1038/ajg.2010.281
    [35] Rajilic-Stojanovic M,Shanahan F,Guarner F,et al. Phylogenetic analysis of dysbiosis in ulcerative colitis during remission[J]. Inflamm Bowel Dis,2013,19(3):481-488. doi: 10.1097/MIB.0b013e31827fec6d
    [36] Kang C S,Ban M,Choi E J,et al. Extracellular vesicles derived from gut microbiota,especially Akkermansia muciniphila,protect the progression of dextran sulfate sodium-induced colitis[J]. PLoS One,2013,8(10):e76520. doi: 10.1371/journal.pone.0076520
    [37] Michalovich D,Rodriguez-Perez N,Smolinska S,et al. Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients[J]. Nat Commun,2019,10(1):e5711. doi: 10.1038/s41467-019-13751-9
    [38] Liu G,Ma H,Qiu L,et al. Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice[J]. Immunol Cell Biol,2011,89(1):130-142. doi: 10.1038/icb.2010.70
    [39] Lanthier N,Leclercq I A. Adipose tissues as endocrine target organs[J]. Best Pract Res Clin Gastroenterol,2014,28(4):545-558. doi: 10.1016/j.bpg.2014.07.002
    [40] Odegaard J I,Chawla A. Connecting type 1 and type 2 diabetes through innate immunity[J]. Cold Spring Harb Perspect Med,2012,2(3):a007724.
    [41] Chevalier C,Stojanovic O,Colin D J,et al. Gut microbiota orchestrates energy homeostasis during cold[J]. Cell,2015,163(6):1360-1374. doi: 10.1016/j.cell.2015.11.004
    [42] Li J,Lin S,Vanhoutte P M,et al. Akkermansia muciniphila protects against atherosclerosis by preventing metabolic endotoxemia-induced inflammation in Apoe-/- mice[J]. Circulation,2016,133(24):2434-2446. doi: 10.1161/CIRCULATIONAHA.115.019645
    [43] Liu J,Li Y,Yang P,et al. Gypenosides reduced the risk of overweight and insulin resistance in C57BL/6J mice through modulating adipose thermogenesis and gut microbiota[J]. J Agric Food Chem,2017,65(42):9237-9246. doi: 10.1021/acs.jafc.7b03382
    [44] Depommier C,Everard A,Druart C,et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers:A proof-of-concept exploratory study[J]. Nat Med,2019,25(7):1096-1103. doi: 10.1038/s41591-019-0495-2
    [45] Liu M N,Zhang L,Dong X Y,et al. Effects of Akkermansia muciniphila on the proliferation,apoptosis and insulin secretion of rat islet cell tumor cells[J]. Sichuan Da Xue Xue Bao Yi Xue Ban,2020,51(1):13-17.
    • 相关文章(20)
  • [1] 李远森, 陈铖, 田衍, 舒若, 徐玉, 李媛华.  海洛因成瘾者不同戒断时间肠道屏障损伤血清标志物的研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230709
    [2] 邓绍友, 赵玉兰, 王佩锦, 李蓉, 李进涛, 郑红.  恒古骨伤愈合剂联合广谱抗生素改善db/db小鼠胰岛素抵抗和肠道菌群, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230530
    [3] 范译丹, 陈玉, 饶春梅, 高雪娟, 张芳, 方山丹, 向润清, 范源, 吴洋.  T2DM患者合并非酒精性脂肪肝与胰岛β细胞功能和胰岛素抵抗的关系, 昆明医科大学学报.
    [4] 李晓红, 马润玫, 陈卓.  肥胖、胰岛素抵抗对妊娠期糖尿病患者血清网膜素-1水平的影响, 昆明医科大学学报.
    [5] 汪君民, 吴晓虹, 王丽, 雷德鸿, 邱良武.  游泳运动对Fetuin-A诱导的胰岛素抵抗大鼠血清IL-2、IL-6的影响, 昆明医科大学学报.
    [6] 杨会军, 杨莹, 彭辉.  β-抑制蛋白2水平与2型糖尿病患者代谢指标变化及胰岛素信号通路相关性的研究进展, 昆明医科大学学报.
    [7] 蒋婷婷.  脂肪因子Vaspin、Apelin及瘦素与多囊卵巢综合征的相关性, 昆明医科大学学报.
    [8] 桂琦.  血清中脂肪因子Apelin、Vaspin、瘦素与子宫内膜癌的相关性, 昆明医科大学学报.
    [9] 王若天.  加速康复外科对结直肠癌患者术后胰岛素信号传导通路中TRB3表达, 昆明医科大学学报.
    [10] 鲍娟.  帕金森病患者轻度认知损害与胰岛素抵抗的相关性, 昆明医科大学学报.
    [11] 范敏娟.  瘦素、胰岛素抵抗与阻塞性睡眠呼吸暂停低通气综合征关系的研究, 昆明医科大学学报.
    [12] 范敏娟.  nCPAP治疗对OSAHS患者血清瘦素水平的影响, 昆明医科大学学报.
    [13] 白永.  天麻素对胰岛素抵抗模型中CBS表达的影响, 昆明医科大学学报.
    [14] 沈丽新.  非酒精脂肪肝病患者ApoB/ApoA1比值与胰岛素抵抗的相关性研究, 昆明医科大学学报.
    [15] 李若楠.  三七总皂苷调控c-Jun氨基末端激酶改善大鼠肝组织胰岛素抵抗的作用, 昆明医科大学学报.
    [16] 刘淑清.  2型糖尿病胰岛素抵抗与认知功能障碍关系研究, 昆明医科大学学报.
    [17] 丘红梅.  代谢综合征患者胰岛素抵抗与血浆醛固酮相关性研究, 昆明医科大学学报.
    [18] .  正常妊娠、妊娠期糖尿病人的胰岛素抵抗状态及胰岛素分泌功能探讨, 昆明医科大学学报.
    [19] .  持续气道正压通气治疗对OSAHS患者胰岛素抵抗的影响, 昆明医科大学学报.
    [20] 桂莉.  2型糖尿病大鼠骨骼肌氧化应激与胰岛素抵抗的关系, 昆明医科大学学报.
    • 施引文献
  • 资源附件(0)
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  3522
  • HTML全文浏览量:  1996
  • PDF下载量:  42
  • 被引次数: 0
出版历程
  • 收稿日期:  2021-12-24
  • 网络出版日期:  2022-01-15
  • 刊出日期:  2022-01-15

目录

    /

    返回文章
    返回

    版权所有 © 《昆明医科大学学报》编辑部  滇ICP备00000000号-0

    编辑出版：昆明医科大学学报编辑部

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计