α7-烟碱乙酰胆碱受体在肺癌发生、发展及治疗中的作用

罗巧; 石宏; 王绍波

doi:10.12259/j.issn.2095-610X.S20220226

α7-烟碱乙酰胆碱受体在肺癌发生、发展及治疗中的作用

doi: 10.12259/j.issn.2095-610X.S20220226

罗巧¹,
石宏^2, ,,
王绍波^{1, 2, ,}

1.
云南省第一人民医院，昆明理工大学附属医院PET/CT中心，云南昆明　650100
2.
昆明理工大学灵长类转化医学研究院，云南昆明　650504

基金项目: 国家自然科学基金项目（81760306）；云南省卫生高层次人才（医学学科带头人）（D－2018011）；云南省“万人计划”青年拔尖人才项目（YNWR-QNBJ-2018-243）

详细信息

作者简介:
罗巧（1994～），女，四川遂宁人，在读硕士研究生，主要从事影像诊断工作

通讯作者:
石宏，E-mail：shih@kust.edu.cn

王绍波，E-mail：15812082912@126.com

中图分类号: R734
计量
- 文章访问数: 3147
- HTML全文浏览量: 1906
- PDF下载量: 21
- 被引次数: 0
出版历程
- 收稿日期: 2021-12-05
- 网络出版日期: 2022-02-24
- 刊出日期: 2022-03-04

Role of α7-nicotinic Acetylcholine Receptor in Occurrence，Development and Therapy of Lung Cancer

Qiao LUO¹,
Hong SHI^{2
, ,},
Shaobo WANG^{1, 2
, ,}

1.
PET/CT Center，the First People Hospital of Yunnan Province，Affiliated Hospital of Kunming University of Science and Technology Kunming Yunnan 650100
2.
Institute of Primate Translational Medicine，Kunming University of Science and Technology，Kunming Yunnan 650504，China

摘要

摘要: 烟碱乙酰胆碱受体（nAChRs）作为兴奋性和抑制性神经递质的中央调节器，控制癌细胞、癌微环境和远处转移生长因子、血管生成因子和神经营养因子的合成和释放。吸烟和其他潜在的不良环境和生活方式等因素上调nAChRs促癌作用并下调其抑癌作用。其中，α7-nAChR在肺癌细胞中高表达，并参与癌细胞的增殖、凋亡和迁移，有望成为肺癌治疗的一个新型靶点。
- α7-nAChR /
- 肺癌 /
- 靶向治疗
Abstract: Nicotinic acetylcholine receptors （nAChRs） are the central regulators of stimulatory and inhibitory neurotransmitters that control the synthesis and release of growth,angiogenic and neurotrophic factors incancer cells, the cancer microenvironment and distantmetastasis. Smoking and other possibly environmental and lifestyle factors increase the function of nAChRs that up-regulates carcinogenesis and down-regulates carcinostasis. α7-nAChRis particularly overexpressed in lung cancer cells, and participates in the proliferation, apoptosis and migration of cancer cells.Thus,α7-nAChR might be a new therapeutic target for lung cancer.
- α7-nAChR /
- Lung neoplasms /
- Molecular targeted therapy

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