Research Progress of Family Lung Cancer in Xuanwei Area of Yunnan Province
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摘要: 云南省宣威地区肺癌发病高居全国首位，是典型的空气污染相关肺癌。近年来宣威肺癌发病率持续快速增长，呈现出明显的家族聚集现象。宣威地区家族肺癌发病年龄提前,腺癌、多原发肺癌占比高，高血压、糖尿病及合并其他癌症情况多见，家族肺癌患者的驱动基因突变谱与遗传背景独特。宣威家族肺癌是研究环境、遗传与肺癌发生的理想对象，就云南省宣威地区家族肺癌研究进展作一综述。Abstract: The incidence of lung cancer in Xuanwei area of Yunnan Province ranks first in China, which is a typical air pollution related lung cancer. In recent years, Xuanwei lung cancer incidence rate continues to grow rapidly, showing a clear phenomenon of family aggregation. The incidence of lung cancer in the Xuanwei area is earlier than that of adenocarcinoma and multiple primary lung cancer. Hypertension, diabetes and other cancers are common. The gene mutation spectrum and genetic background of family lung cancer patients are unique. Xuanwei family lung cancer is an ideal object to study the environment, genetics and occurrence of lung cancer. This paper reviews the research progress of family lung cancer in Xuanwei area of Yunnan Province.
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图 1 肺癌发病率高、遗传背景和环境污染
Figure 1. High lung cancer rate，genetic background and environmental pollution
图 2 宣威地区典型肺癌家系（男性和女性）
Figure 2. Typical lung cancer family tree in Xuanwei region（Female and Male）
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