灯盏花乙素抗氧化应激机制在防治心脑血管疾病中的研究进展

董丽; 孙士波; 孙曙光

doi:10.12259/j.issn.2095-610X.S20220423

灯盏花乙素抗氧化应激机制在防治心脑血管疾病中的研究进展

doi: 10.12259/j.issn.2095-610X.S20220423

董丽^{1, 2},
孙士波³,
孙曙光^4, ,

1.
大理大学临床医学院，云南大理　671000
2.
陇川县城子镇中心卫生院，云南德宏　678701
3.
昆明医科大学第一附属医院呼吸与危重医学科，云南昆明　650032
4.
大理大学第一附属医院内分泌科，云南大理　671000

基金项目: 国家自然科学基金资助项目（82160007）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2019FE001（-058）]；云南省科技厅地方高校联合专项基金资助项目（202001BA070001-016）

详细信息

作者简介:
董丽（1993～），女，景颇族，云南陇川人，在读硕士研究生，主治医师，主要从事全科医学的临床研究工作

通讯作者:
孙曙光，E-mail：sshuglily@163.com

中图分类号: R285
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出版历程
- 收稿日期: 2022-02-14
- 网络出版日期: 2022-03-23
- 刊出日期: 2022-04-25

Advances on Scutellarin Anti-Oxidative Stress Mechanism in the Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases

Li DONG^{1, 2},
Shibo SUN³,
Shuguang SUN^{4
, ,}

1.
Clinical Medical College，Dali University，Dali Yunnan 671000
2.
Central Health Center of Chengzi Town，Longchuan County，Dehong Yunnan 678701
3.
Dept. of Respiratory and Critical Care Medicine，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
4.
Dept. of Endocrinology，The 1st Affiliated Hospital of Dali University，Dali Yunnan 671000，China

摘要

摘要: 灯盏花乙素，化学名为4，5，6-三羟基黄酮-7-葡糖苷酸，是中国传统中药灯盏花的主要活性成分。临床上，因其具有极其广泛的生物活性而被用于治疗心脑血管疾病。近年来，以高发病率、高死亡率为特点的心脑血管疾病已经成为中老年人的常见多发病，并随着人们饮食结构的转变，不良生活习惯的养成使该病的发病有了年轻化的趋势。氧化应激是心脑血管疾病发生、发展中极其重要的因素。而灯盏花乙素对心脑血管疾病的治疗有较好疗效，不难发现，灯盏花乙素对氧化应激有一定的抑制作用。旨在对灯盏花乙素与氧化应激的作用机制进行综述，并探讨灯盏花乙素对氧化应激抑制作用在临床上的应用，从而为今后临床疾病的治疗提供一定的参考。
- 灯盏花乙素 /
- 氧化应激 /
- 心脑血管疾病
Abstract: Scutellarin, chemically named 4, 5, 6-trihydroxyflavone-7-glucosidic acid, is the main active ingredient of the traditional Chinese medicine Breviscapus. Clinically, it has been used in the treatment of cardiovascular and cerebrovascular diseases because of its extremely wide biological activities. In recent years, cardiovascular and cerebrovascular diseases characterized by high morbidity and mortality have become common and frequently-occurring diseases among middle-aged and elderly people. With the change of people’ s diet, unhealthy life style, the onset of the disease has a trend of younger age. Studies have shown that oxidative stress is an extremely important factor in the occurrence and development of cardiovascular and cerebrovascular diseases. Scutellarin has a better therapeutic effect on the treatment of cardiovascular and cerebrovascular diseases. Therefore, it is not difficult to find that scutellarin has a certain inhibitory effect on oxidative stress. This article reviews the mechanism of scutellarin and oxidative stress, and to explore the clinical application of scutellarin to inhibit oxidative stress, so as to provide a certain evidence for the treatment of clinical diseases in the future.
- Scutellarin /
- Oxidative stress /
- Cardiovascular and cerebrovascular diseases

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参考文献(51)

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灯盏花乙素抗氧化应激机制在防治心脑血管疾病中的研究进展

doi: 10.12259/j.issn.2095-610X.S20220423

作者简介:
董丽（1993～），女，景颇族，云南陇川人，在读硕士研究生，主治医师，主要从事全科医学的临床研究工作

通讯作者:
孙曙光，E-mail：sshuglily@163.com

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Advances on Scutellarin Anti-Oxidative Stress Mechanism in the Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases

计量

目录

[1]	李威, 蒋立虹, 马丽晶, 陈锐, 杨童硕. 铁死亡在心肌病中的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240327
[2]	谭莹, 秦海燕, 孙翔, 苏彦伊, 王英宝. 丙泊酚调节MPP+诱导的SH-SY5Y细胞线粒体氧化应激和凋亡, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240305
[3]	陆凤华, 杜兆霖, 章容. 红光照射联合下肢肌力训练对糖尿病周围神经病变患者下肢运动功能、TCSS评分及SOD水平的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230129
[4]	白文娅, 杨渊, 霍思颖, 杨鑫, 邵建林. 胆绿素治疗作用的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220601
[5]	薛国强, 卫欣欣, 姚娜, 赵文化. 二甲双胍通过调控PARP-1活性对2型糖尿病肾脏的保护作用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210632
[6]	郭安利, 付昌碧, 杨晓晴, 张士梅, 石正娟. 急性脑梗死患者肺部感染对氧化应激与炎性应激的影响, 昆明医科大学学报.
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[8]	戴青里, 孙贵虎, 闫斌, 郭涛, 戴青原. 过氧化氢诱导HUVECs氧化应激模型的构建, 昆明医科大学学报.
[9]	陈晨, 王友兰, 刘伟军, 饶嫱, 杜庭彦, 杜晓华, 杨为民, 朱秀芬. 灯盏花乙素对人心脏微血管内皮细胞中PKCε表达的调控作用, 昆明医科大学学报.
[10]	曾柏瑞. 甲基苯丙胺与HIV-Tat蛋白协同改变大鼠血脑屏障通透性的氧化应激作用机制, 昆明医科大学学报.
[11]	边海霞. 单纯疱疹病毒性角膜炎抗氧化治疗的临床观察, 昆明医科大学学报.
[12]	刘松. 1 800 MHz电磁波对大鼠心肌氧化应激的影响, 昆明医科大学学报.
[13]	丁艳杰. 类风湿合并颈动脉硬化患者血清氧化应激状态与MMPs相关性分析, 昆明医科大学学报.
[14]	胡娜. 灯盏花乙素和双嘧达莫舒张离体大鼠心脑血管的药理作用, 昆明医科大学学报.
[15]	张媛. 1 800 MHz电磁辐射对大鼠皮肤组织氧化应激的影响, 昆明医科大学学报.
[16]	李若楠. 三七总皂苷调控c-Jun氨基末端激酶改善大鼠肝组织胰岛素抵抗的作用, 昆明医科大学学报.
[17]	王心昕. 膳食脂肪酸摄入及构成与心脑血管疾病相关性的研究进展, 昆明医科大学学报.
[18]	闫庆峰. 木犀草素对冷保存大鼠心脏心功能及氧化应激反应的影响, 昆明医科大学学报.
[19]	. 灯花乙素和灯盏花乙素苷元表观油水分配系数的测定与比较, 昆明医科大学学报.
[20]	桂莉. 2型糖尿病大鼠骨骼肌氧化应激与胰岛素抵抗的关系, 昆明医科大学学报.

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灯盏花乙素抗氧化应激机制在防治心脑血管疾病中的研究进展

doi: 10.12259/j.issn.2095-610X.S20220423

作者简介: 董丽（1993～），女，景颇族，云南陇川人，在读硕士研究生，主治医师，主要从事全科医学的临床研究工作

通讯作者: 孙曙光，E-mail：sshuglily@163.com

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Advances on Scutellarin Anti-Oxidative Stress Mechanism in the Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases

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出版历程

目录

作者简介:
董丽（1993～），女，景颇族，云南陇川人，在读硕士研究生，主治医师，主要从事全科医学的临床研究工作

通讯作者:
孙曙光，E-mail：sshuglily@163.com