乙肝病毒感染在妇科恶性肿瘤发生发展中的研究进展

陈晓洁; 吴星娆; 于书慧; 李政; 张岚

doi:10.12259/j.issn.2095-610X.S20220424

乙肝病毒感染在妇科恶性肿瘤发生发展中的研究进展

doi: 10.12259/j.issn.2095-610X.S20220424

1.
偃师市中医院药剂科，河南洛阳　471900
2.
云南省肿瘤医院/昆明医科大学第三附属医院/云南省癌症中心放疗科
3.
妇瘤科，云南昆明　650118

基金项目: 国家自然科学基金资助项目（81802614）；华南肿瘤学国家重点实验室开放课题基金资助项目（KY012294）；云南省科技计划研究基金资助项目[2019FE001（-151）；2019FD090]；云南省卫生健康委员会医学后备人才基金资助项目（H-2018003）；昆明医科大学百名中青年学术技术骨干基金资助项目（60119260117）

详细信息

作者简介:
陈晓洁（1988～），女，河南洛阳人，药学学士，药师，主要从事临床药学工作

通讯作者:
张岚，E-mail： zhanglan@kmmu.edu.cn

中图分类号: R737.3
计量
- 文章访问数: 2807
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- PDF下载量: 18
- 被引次数: 0
出版历程
- 收稿日期: 2022-02-23
- 刊出日期: 2022-04-25

Advances on HBV Infection in the Occurrence and Development of Gynecologic Malignancies

1.
Dept. of Pharmacy，Yanshi Traditional Chinese Medicine Hospital，Luoyang Henan 471900
2.
Dept. of Radiotherapy，Yunnan Cancer Hospital，The 3rd Affiliated Hospital of Kunming Medical University
3.
Dept. of Gynecologic Oncology，Yunnan Cancer Hospital，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

摘要

摘要: 感染是癌症发生发展的重要因素，全球约15%的癌症与感染有关。乙型肝炎病毒（hepatitis B virus，HBV）不仅能感染肝细胞，是肝癌的主要病因；还能感染肝外细胞引起慢性炎症，与多种肝外肿瘤的发生发展密切相关。女性生殖器官通过阴道与外界环境相通，HBV携带者的阴道分泌物及卵巢组织可检测出病毒核酸，一些流行病学研究显示HBV感染可能增加妇科恶性肿瘤的发病风险，与患者不良预后相关。常见的妇科恶性肿瘤包括宫颈癌、子宫内膜癌及卵巢癌。综述近年来HBV感染与妇科恶性肿瘤的相关性研究，分析HBV感染参与妇科恶性肿瘤发生发展的潜在机制，对未来研究方向做出展望。
- 乙型肝炎病毒 /
- 妇科恶性肿瘤 /
- 发生 /
- 发展
Abstract: The incidence of human cancers attributable to infectious agents has been estimated to be 15%. Hepatitis B virus（HBV） infects hepatocytes causing hepatocellular carcinoma. It can also infect extrahepatic cells and cause chronic inflammation, which is associated with a variety of extrahepatic cancers. Female reproductive organs communicate with the external environment through vagina. Viral nucleic acid can be detected in the vaginal secretions and ovarian tissues of HBV carriers. Epidemiological studies suggested HBV infection may be a risk factor for gynecologic malignancies, and related to poor prognosis of patients. Cervical cancer, endometrial cancer and ovarian cancer are most common gynecologic malignancies. This paper reviews the recent studies on the association between HBV infection and gynecologic malignancies, and analyzes the potential mechanism of HBV infection in the occurrence and development of cancer and prospects the future research direction.
- HBV /
- Gynecologic malignancies /
- Occurrence /
- Development

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