留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

海洛因造成呼吸系统损伤研究进展

周勇,  张尊月,  杨继青,  熊普,  王昆华

downloadPDF
文章导航 > 昆明医科大学学报  > 2022 >  43(5): 155-161
周勇, 张尊月, 杨继青, 熊普, 王昆华. 海洛因造成呼吸系统损伤研究进展[J]. 昆明医科大学学报, 2022, 43(5): 155-161. doi: 10.12259/j.issn.2095-610X.S20220525
引用本文: 周勇, 张尊月, 杨继青, 熊普, 王昆华. 海洛因造成呼吸系统损伤研究进展[J]. 昆明医科大学学报, 2022, 43(5): 155-161. doi: 10.12259/j.issn.2095-610X.S20220525
shu
Yong ZHOU, Zunyue ZHANG, Jiqing YANG, Pu XIONG, Kunhua WANG. Research Progress of Heroin-induced Respiratory Damage[J]. Journal of Kunming Medical University, 2022, 43(5): 155-161. doi: 10.12259/j.issn.2095-610X.S20220525
Citation: Yong ZHOU, Zunyue ZHANG, Jiqing YANG, Pu XIONG, Kunhua WANG. Research Progress of Heroin-induced Respiratory Damage[J]. Journal of Kunming Medical University, 2022, 43(5): 155-161. doi: 10.12259/j.issn.2095-610X.S20220525
shu

海洛因造成呼吸系统损伤研究进展

doi: 10.12259/j.issn.2095-610X.S20220525

  • 国家卫健委毒品依赖和戒治重点实验室，昆明医科大学第一附属医院科研实验中心，云南 昆明　650032

基金项目: 国家自然科学基金资助项目（81870458）；云南省消化疾病防治工程技术研究中心基金资助项目（2018DH006）；云南省云岭学者基金资助项目（YLXL20170002；YLXL20170002）；云南省普通外科疾病临床医学中心基金资助项目（ZX2019-03-03）；云南省教育厅科学研究基金资助项目（2021J0234）
详细信息
    作者简介:

    周勇（1989～），男，云南昆明人，博士研究生，主治医师，主要从事毒品依赖和戒治相关研究工作

    通讯作者:

    王昆华，E-mail：Kunhuawang1@163.com

  • 中图分类号: R996

Research Progress of Heroin-induced Respiratory Damage

  • NHC Key Laboratory of Drug Addiction Medicine，The Scientific Research Laboratory Center，The 1st Affiliated Hospitalof Kunming Medical University，Kunming Yunnan 650032，China

    摘要
  • 摘要: 海洛因是一种可以多途径摄入且成瘾性极强的毒品，严重损害人类健康，其中对呼吸系统的影响和损伤是广泛而明显的。它可以通过抑制呼吸中枢而导致呼吸抑制，可以直接损伤气道和肺组织而导致鼻咽部溃疡或者肺气肿，也可以影响机体的免疫而导致哮喘或者嗜酸性粒细胞性肺炎，还可以导致非心源性肺水肿。不仅如此，吸食海洛因的人群由于其心理社会环境因素，还是肺炎、肺结核等肺部感染性疾病的高风险人群。现将对海洛因对呼吸系统的影响进行归纳和总结，以更加全面了解海洛因对呼吸系统的影响。
    Abstract: Heroin, a highly addictive drug that seriously harms the human health, can be ingested in multiple ways. Severe damages are commonly observed in the respiratory system. As an exogenous opioid, heroin can cause the respiratory depression by inhibiting the respiratory center. In fact, heroin affects the respiratory system in many other ways. It not only causes nasopharyngeal ulcers or emphysema by directly damaging the airways and lung tissues, but also induces asthma or eosinophilic pneumonia by affecting the body’s immunity. In addition, pulmonary toxicity of heroin can cause noncardiogenic pulmonary edema and pneumothorax when drugs are injected into the jugular vein. Because of the psychosocial environmental factors, heroin users are also at a high risk for pulmonary infectious diseases, such as pneumonia and tuberculosis. This article will provide a better understanding of the effects of heroin on the respiratory system by reviewing the current literature.
    • HTML全文
    • 参考文献(65)
  • [1] Lao P N. The effects of opiates on the lung[J]. Clinical Reviews in Allergy & Immunology,1997,15(3):291-305.
    [2] Radke J B,Owen K P,Sutter M E,et al. The effects of opioids on the lung[J]. Clinical Reviews in Allergy & Immunology,2014,46(1):54-64.
    [3] Sneader W. The discovery of heroin[J]. Lancet,1998,352(9141):1697-1699. doi: 10.1016/S0140-6736(98)07115-3
    [4] Compton W M,Jones C M,Baldwin G T. Relationship between nonmedical prescription-opioid use and heroin use[J]. The New England Journal of Medicine,2016,374(2):154-163. doi: 10.1056/NEJMra1508490
    [5] Mégarbane B,Chevillard L. The large spectrum of pulmonary complications following illicit drug use:Features and mechanisms[J]. Chemico-Biological Interactions,2013,206(3):444-451. doi: 10.1016/j.cbi.2013.10.011
    [6] Wolff A J,O'Donnell A E. Pulmonary effects of illicit drug use[J]. Clinics in Chest Medicine,2004,25(1):203-216. doi: 10.1016/S0272-5231(03)00137-0
    [7] Stein C. Opioid receptors[J]. Annual Review of Medicine,2015,67(1):433.-451.
    [8] Cox B M. Recent developments in the study of opioid receptors[J]. Molecular Pharmacology,2013,83(4):723-728. doi: 10.1124/mol.112.083279
    [9] Katritch V,Cherezov V,Stevens R C. Structure-function of the G protein-coupled receptor superfamily[J]. Annual Review of Pharmacology & Toxicology,2013,53(1):531-556.
    [10] Law P Y,Reggio P H,Loh H H. Opioid receptors:Toward separation of analgesic from undesirable effects[J]. Trends in Biochemical Sciences,2013,38(6):275-282. doi: 10.1016/j.tibs.2013.03.003
    [11] Zebraski S E,Kochenash S M,Raffa R B. Lung opioid receptors:Pharmacology and possible target for nebulized morphine in dyspnea[J]. Life Sciences,2000,66(23):2221-2231. doi: 10.1016/S0024-3205(00)00434-3
    [12] Gómez-Román J J,Cifrián Martínez J M,Fernández Rozas S,et al. Hormone expression and opioid receptors in fetal and adult lung[J]. Archivos De Bronconeumologia,2002,38(8):362-366. doi: 10.1016/S0300-2896(02)75240-X
    [13] Peng J,Sarkar S,Chang S L. Opioid receptor expression in human brain and peripheral tissues using absolute quantitative real-time RT-PCR[J]. Drug & Alcohol Dependence,2012,124(3):223-228.
    [14] Sulaiman M,Kunalan V,Yap A T W,et al. Heroin in Malaysia and Singapore[J]. Drug Testing and Analysis,2018,10(1):109-119. doi: 10.1002/dta.2238
    [15] Dettmeyer R B,Verhoff M A,Brückel B,et al. Widespread pulmonary granulomatosis following long time intravenous drug abuse-A case report[J]. Forensic Science International,2010,197(1-3):e27-e30. doi: 10.1016/j.forsciint.2009.12.066
    [16] Cole C,Jones L,Mcveigh J,et al. Adulterants in illicit drugs:A review of empirical evidence[J]. Drug Testing and Analysis,2011,3(2):89-96. doi: 10.1002/dta.220
    [17] Gasior M,Bond M,Malamut R. Routes of abuse of prescription opioid analgesics:A review and assessment of the potential impact of abuse-deterrent formulations[J]. Postgraduate Medicine,2016,128(1):85-96. doi: 10.1080/00325481.2016.1120642
    [18] Dahan A,Aarts L,Smith T W. Incidence,reversal,and prevention of opioid-induced respiratory depression[J]. Anesthesiology,2010,112(1):226-238. doi: 10.1097/ALN.0b013e3181c38c25
    [19] Lötsch J,Dudziak R,Freynhagen R,et al. Fatal respiratory depression after multiple intravenous morphine injections[J]. Clinical Pharmacokinetics,2006,45(11):1051-1060. doi: 10.2165/00003088-200645110-00001
    [20] Pattinson K T. Opioids and the control of respiration[J]. BJA British Journal of Anaesthesia,2008,100(6):747-758. doi: 10.1093/bja/aen094
    [21] Montandon G,Qin W,Liu H,et al. PreBotzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience,2011,31(4):1292-301. doi: 10.1523/JNEUROSCI.4611-10.2011
    [22] White J M,Irvine R J. Mechanisms of fatal opioid overdose[J]. Addiction,1999,94(7):961-972. doi: 10.1046/j.1360-0443.1999.9479612.x
    [23] Boom M,Niesters M,Sarton E,et al. Non-analgesic effects of opioids:opioid-induced respiratory depression[J]. Current Pharmaceutical Design,2012,18(37):5994-6004. doi: 10.2174/138161212803582469
    [24] Yeadon M,Kitchen I. Opioids and respiration[J]. Progress in Neurobiology,1989,33(1):1-16. doi: 10.1016/0301-0082(89)90033-6
    [25] Dahan A,Sarton E,Teppema L,et al. Anesthetic potency and influence of morphine and sevoflurane on respiration in mu-opioid receptor knockout mice[J]. Anesthesiology,2001,94(5):824-832. doi: 10.1097/00000542-200105000-00021
    [26] Romberg R,Sarton E,Teppema L,et al. Comparison of morphine-6-glucuronide and morphine on respiratory depressant and antinociceptive responses in wild type and μ-opioid receptor deficient mice[J]. British Journal of Anaesthesia,2003,91(6):862-870. doi: 10.1093/bja/aeg279
    [27] Coruh B,Tonelli M R,Park D R. Fentanyl-induced chest wall rigidity[J]. Chest,2013,143(4):1145-1146. doi: 10.1378/chest.12-2131
    [28] Van D,Ceelie I,Wildt S D. Morphine-induced muscle rigidity in a term neonate.[J]. Annals of Pharmacotherapy,2009,43(10):1724-1726. doi: 10.1345/aph.1M268
    [29] Dimitriou V,Zogogiannis I,Liotiri D,et al. Impossible mask ventilation after an unusually low dose fentanyl-induced muscle rigidity in a patient with essential tremor:A case report and review of the literature[J]. Middle East J Anaesthesiol,2014,22(6):619-622.
    [30] Glick C,Evans O B,Parks B R. Muscle rigidity due to fentanyl infusion in the pediatric patient[J]. Southern Medical Journal,1996,89(11):1119-20. doi: 10.1097/00007611-199611000-00023
    [31] Viscomi C M, Bailey P L. Opioid-induced rigidity after intravenous fentanyl[J]. Obstet Gynecol, 1997, 89（5 Pt 2）: 822-824.
    [32] Bennett J A,Abrams J T,Van Riper D F,et al. Difficult or impossible ventilation after sufentanil-induced anesthesia is caused primarily by vocal cord closure[J]. Anesthesiology,1997,87(5):1070-1074. doi: 10.1097/00000542-199711000-00010
    [33] Sokoll M D,Hoyt J L,Gergis S D. Studies in muscle rigidity,nitrous oxide,and narcotic analgesic agents[J]. Anesthesia & Analgesia,1972,51(1):16-20.
    [34] Freye E,Kuschinsky K. Effects of fentanyl and droperidol on the dopamine metabolism of the rat striatum[J]. Pharmacology,1976,14(1):1-7.
    [35] Gonik N J,Bluth M H. Otolaryngology concerns for illicit and prescription drug use[J]. Clinics in Laboratory Medicine,2016,36(4):745-752. doi: 10.1016/j.cll.2016.07.012
    [36] Alexander D,Alexander K,Valentino J. Intranasal hydrocodone-acetaminophen abuse induced necrosis of the nasal cavity and pharynx[J]. Laryngoscope,2012,122(11):2378-2381. doi: 10.1002/lary.23542
    [37] Walker P P,Thwaite E,Amin S,et al. The association between heroin inhalation and early onset emphysema[J]. Chest,2015,148(5):1156-1163. doi: 10.1378/chest.15-0236
    [38] Burhan H,Young R,Byrne T,et al. Screening heroin smokers attending community drug services for COPD[J]. Chest,2019,155(2):279-287. doi: 10.1016/j.chest.2018.08.1049
    [39] Ford E S,Mannino D M,Wheaton A G,et al. Trends in the prevalence of obstructive and restrictive lung function among adults in the United States:Findings from the National Health and Nutrition Examination surveys from 1988-1994 to 2007-2010[J]. Chest,2013,143(5):1395-1406. doi: 10.1378/chest.12-1135
    [40] Tashkin D P. Heroin smoking and COPD:A case for targeted screening spirometry[J]. Chest,2019,155(2):247-248. doi: 10.1016/j.chest.2018.08.1039
    [41] Goldstein D S,Karpel J P,Appel D,et al. Bullous pulmonary damage in users of intravenous drugs[J]. Chest,1986,89(2):266-269. doi: 10.1378/chest.89.2.266
    [42] Jay A L. Reduced lung function and bullae resulting from illicit drug use[J]. JAAPA:Official Journal of the American Academy of Physician Assistants,2011,24(7):26-9,33. doi: 10.1097/01720610-201107000-00006
    [43] Mell H K,Sztajnkrycer M D. Clinical images in medical toxicology:heroin overdose with non-cardiogenic pulmonary edema[J]. Clinical Toxicology,2006,44(4):399. doi: 10.1080/15563650600671803
    [44] Duberstein J L,Kaufman D M. A clinical study of an epidemic of heroin intoxication and heroin-induced pulmonary edema[J]. American Journal of Medicine,1971,51(6):704-714. doi: 10.1016/0002-9343(71)90298-1
    [45] Sterrett C,Brownfield J,Korn C S,et al. Patterns of presentation in heroin overdose resulting in pulmonary edema[J]. American Journal of Emergency Medicine,2003,21(1):32-34. doi: 10.1053/ajem.2003.50006
    [46] Griffith C C, Raval J S, Nichols L. Intravascular talcosis due to intravenous drug use is an underrecognized cause of pulmonary hypertension[J]. Pulmonary Medicine, 2012, （2012-5-7）, 2012, 2012: 617531.
    [47] Marchiori E,Lourenço S,Gasparetto T D,et al. Pulmonary talcosis:Imaging findings[J]. Lung,2010,188(2):165-71. doi: 10.1007/s00408-010-9230-y
    [48] Douglas F G,Kafilmout K J,Patt N L. Foreign particle embolism in drug addicts:Respiratory pathophysiology[J]. Annals of Internal Medicine,1971,75(6):865. doi: 10.7326/0003-4819-75-6-865
    [49] Riccardello G J,Maldjian P D. Pulmonary hemorrhage in acute heroin overdose:A report of two cases.[J]. Emergency Radiology,2017,24(6):709-12. doi: 10.1007/s10140-017-1531-5
    [50] Zhang X Y,Liang Y X,Yan Y,et al. Morphine:Double-faced roles in the regulation of tumor development[J]. Clinical and Translational Oncology,2017,20(7):808-814.
    [51] Krantz A J,Hershow R C,Prachand N,et al. Heroin insufflation as a trigger for patients with life-threatening asthma[J]. Chest,2003,123(2):510-517. doi: 10.1378/chest.123.2.510
    [52] Popa V. Codeine-induced bronchoconstriction and putative bronchial opiate receptors in asthmatic subjects[J]. Pulmonary Pharmacology,1994,7(5):333-341. doi: 10.1006/pulp.1994.1039
    [53] Underner M, Perriot J, Peiffer G, et al. Asthma and heroin use[J]. Presse Medicale （Paris, France : 1983）, 2017, 46（7-8 Pt 1）: 660-675.
    [54] Cygan J,Trunsky M,Corbridge T. Inhaled heroin-induced status asthmaticus:Five cases and a review of the literature[J]. Chest,2000,117(1):272-275. doi: 10.1378/chest.117.1.272
    [55] Flacke J W,Flacke W E,Bloor B C,et al. Histamine release by four narcotics:A double-blind study in humans[J]. Anesthesia & Analgesia,1987,66(8):723-730.
    [56] Eyüpoğlu D,Ersoy E O,Rollas K,et al. Acute eosinophilic pneumonia secondary to heroin inhalation[J]. Tuberkuloz ve toraks,2017,65(2):154-156. doi: 10.5578/tt.10438
    [57] Underner M,Perriot J,Peiffer G,et al. Acute eosinophilic pneumonia and illicit psychoactive substance use[J]. Revue des Maladies Respiratoires,2020,37(1):34-44. doi: 10.1016/j.rmr.2019.07.010
    [58] Deroux A,Buisson T T,Bernard C,et al. Acute interstitial pneumonia following heroin inhalation[J]. Presse Medicale (Paris,France:1983),2015,44(1):119-121.
    [59] Roy S,Ninkovic J,Banerjee S,et al. Opioid drug abuse and modulation of immune function:Consequences in the susceptibility to opportunistic infections[J]. Journal of Neuroimmune Pharmacology:The Official Journal of the Society on NeuroImmune Pharmacology,2011,6(4):442-465. doi: 10.1007/s11481-011-9292-5
    [60] Kaushik K S,Kapila K,Praharaj A K. Shooting up:the interface of microbial infections and drug abuse[J]. Journal of Medical Microbiology,2011,60(4):408-422. doi: 10.1099/jmm.0.027540-0
    [61] Mitchell D M,Miller R F. AIDS and the lung:update 1992.2. Recent developments in the management of the pulmonary complications of HIV disease[J]. Thorax,1992,47(5):381-390. doi: 10.1136/thx.47.5.381
    [62] Dublin S,Walker R L,Jackson M L,et al. Use of opioids or benzodiazepines and risk of pneumonia in older adults:a population-based case-control study[J]. Journal of the American Geriatrics Society,2011,59(10):1899-1907. doi: 10.1111/j.1532-5415.2011.03586.x
    [63] Edelman E J,Gordon K S,Crothers K,et al. Association of prescribed opioids with increased risk of community-acquired pneumonia among patients with and without HIV[J]. JAMA Internal Medicine,2019,179(3):297-304. doi: 10.1001/jamainternmed.2018.6101
    [64] Gottlieb L S,Boylen T C. Pulmonary complications of drug abuse[J]. The Western Journal of Medicine,1974,120(1):8-16.
    [65] Deiss R G,Rodwell T C,Garfein R S. Tuberculosis and illicit drug use:Review and update[J]. Clinical Infectious Diseases An Official Publication of the Infectious Diseases Society of America,2009,48(1):72-82. doi: 10.1086/594126
    • 相关文章(20)
  • [1] 李远森, 陈铖, 田衍, 舒若, 徐玉, 李媛华.  海洛因成瘾者不同戒断时间肠道屏障损伤血清标志物的研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230709
    [2] 汤一鸣, 陈瑜, 陆一鸣, 章学美, 尹姜黎.  高原性肺水肿患者应用针对性护理模式的价值, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220427
    [3] 周玉娥, 尹丽娟, 杨慧波.  俯卧位对早产儿呼吸暂停的影响, 昆明医科大学学报.
    [4] 李丽萍, 赵洪超, 张云珠, 李俊.  抗VEGF治疗视网膜静脉阻塞伴黄斑水肿患者疗效及预后影响因素, 昆明医科大学学报.
    [5] 周云春, 董文斌, 李世福, 陈黎跃, 张继华.  呼吸系统疾病住院患者医院感染的相关因素, 昆明医科大学学报.
    [6] 江平飞, 胡强.  血流动力学及呼吸力学参数在呼吸衰竭患者中的变化, 昆明医科大学学报.
    [7] 李丽萍, 王关顺, 马坚, 陈迪, 丁莹莹.  表观扩散系数在急性间质水肿性胰腺炎与急性坏死性胰腺炎中的价值, 昆明医科大学学报.
    [8] 张敏, 刘萍, 陈淼航, 唐玲玲, 陈绍庆.  静脉输注利多卡因在海洛因依赖者上消化道异物取出术中的应用, 昆明医科大学学报.
    [9] 唐睿珠, 罗正琼, 徐秋月, 赵滢, 李欢, 王云娟, 宋宇, 刘子杰.  呼吸道病原体核酸恒温扩增芯片十三联检在下呼吸道感染常见病原体基因中的检测, 昆明医科大学学报.
    [10] 李正超, 钱传云, 吴海鹰, 张玮, 夏婧.  右美托咪定对重度颅脑创伤大鼠脑水肿程度的影响, 昆明医科大学学报.
    [11] 何蓉, 王丽, 郭永莉, 陈绍春.  基于Android平台的系统解剖学学习系统研究及使用效果, 昆明医科大学学报.
    [12] 田明.  螺蛳分子系统发育的初步研究, 昆明医科大学学报.
    [13] 杨林红.  眼内注射康柏西普治疗视网膜分支静脉阻塞继发黄斑水肿的临床观察, 昆明医科大学学报.
    [14] 肖欣.  消化系统粒细胞肉瘤临床病理分析, 昆明医科大学学报.
    [15] 何成禄.  呼吸道九联检IgM检测对儿童急性下呼吸道感染的早期诊断价值, 昆明医科大学学报.
    [16] 王翔波.  复张性肺水肿的临床观察及护理体会, 昆明医科大学学报.
    [17] 蔡永锋.  27例吸毒者死亡的法医学鉴定分析, 昆明医科大学学报.
    [18] .  振动反应成像系统肺部定量数据变异分析, 昆明医科大学学报.
    [19] .  高渗盐水对重症脑外伤脑水肿患者电解质和渗透压影响的临床观察, 昆明医科大学学报.
    [20] .  肺功能检测在小儿呼吸系统疾病诊治中的应用, 昆明医科大学学报.
    • 施引文献
  • 资源附件(0)
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  2541
  • HTML全文浏览量:  1758
  • PDF下载量:  20
  • 被引次数: 0
出版历程
  • 收稿日期:  2022-01-18
  • 网络出版日期:  2022-05-06
  • 刊出日期:  2022-05-27

目录

    /

    返回文章
    返回

    版权所有 © 《昆明医科大学学报》编辑部  滇ICP备00000000号-0

    编辑出版：昆明医科大学学报编辑部

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计