糖尿病脑病的发病机制研究进展

武翠玲; 刘弘毅; 范源; 刘嘉瑞

doi:10.12259/j.issn.2095-610X.S20220733

糖尿病脑病的发病机制研究进展

doi: 10.12259/j.issn.2095-610X.S20220733

武翠玲¹,
刘弘毅²,
范源^{1, 3, ,},
刘嘉瑞^3, ,

1.
云南中医药大学第一临床医学院，云南昆明　650500
2.
云南省中医医院内分泌科，云南昆明　650041
3.
云南中医药大学第二附属医院内分泌科，云南昆明　650216

基金项目: 国家自然科学基金资助项目（81760856）；云南省科技厅应用基础研究计划项目（202101AZ010001-015）

详细信息

作者简介:
武翠玲（1994～），女，云南昆明人，在读硕士研究生，主要从事中西医结合防治内分泌代谢性疾病的研究工作

通讯作者:
范源，E-mail：1647909799@qq.com

刘嘉瑞，E-mail：2308602568@qq.com

中图分类号: R587.2
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- 被引次数: 0
出版历程
- 收稿日期: 2022-01-14
- 刊出日期: 2022-07-14

Research Progress in Pathogenesis of Diabetic Encephalopathy

Cuiling WU¹,
Hongyi LIU²,
Yuan FAN^{1, 3
, ,},
Jiarui LIU^{3
, ,}

1.
First School of Clinic Medicine，Yunnan University of Traditional Chinese Medicine，Kunming Yunnan 650500
2.
Dept. of Endocrinology，Yunnan Provincial Hospital of Traditional Chinese Medicine，Kunming Yunnan 650041
3.
Dept. of Endocrinology，The Second Affiliated Hospital of Yunnan University of Traditional Chinese Medicine，Kunming Yunnan 650216，China

摘要

摘要: 糖尿病脑病（diabetic encephalopathy，DE）是一种与糖尿病相关的慢性并发症之一，受多种危险因素影响，其主要临床表现为认知功能减退、决策障碍及情绪障碍等。目前其可能的发病机制有胰腺淀粉样多肽稳态失衡、MicroRNAs、巨噬细胞自噬、脂素Lipin1、晚期糖基化终末产物（AGEs）、氧化应激、Tau蛋白过度磷酸化、钙稳态失调等，多种机制共同作用，影响脑内组织细胞的功能，引起糖尿病脑病相应的病理改变，促成糖尿病脑病的发生发展。
- 糖尿病脑病 /
- 3型糖尿病 /
- 认知功能障碍 /
- 发病机制
Abstract: Diabetic encephalopathy （DE） is one of the chronic complications associated with diabetes. It is affected by many risk factors. Its main clinical manifestations are cognitive impairment, decision making disorders and emotional disorders. At present, the possible pathogenesis is pancreatic amyloid polypeptide homeostasis imbalance, MicroRNAs, macrophage autophagy, lipoprotein Lipin1, advanced glycation end products （AGEs）, oxidative stress, overphosphorylation of Tau protein, calcium homeostasis, and other mechanisms, which affect the function of brain tissue cells and cause corresponding pathological changes of diabetic encephalopathy. Promote the development of diabetic encephalopathy.
- Diabetic encephalopathy /
- Type 3 diabetes /
- Cognitive dysfunction /
- Pathogenesis

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参考文献(50)

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