Smad4与嗅觉系统功能及疾病的研究进展

张切; 王淑芬; 曹守明; 吴海莺

doi:10.12259/j.issn.2095-610X.S20220826

Smad4与嗅觉系统功能及疾病的研究进展

doi: 10.12259/j.issn.2095-610X.S20220826

1.
昆明医科大学第二附属医院耳鼻咽喉科, 云南昆明　650101
2.
昆明医科大学生物医学工程研究中心云南省干细胞和再生医学重点实验室, 云南昆明　650500

基金项目: 国家自然科学基金资助项目（81960240，31460314）;　云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202001AY070001-001，202201AY070001-122）

详细信息

作者简介:
张切（1995～），男，湖北随州人，在读硕士研究生，主要从事鼻颅底及嗅觉障碍临床与基础研究工作

通讯作者:
吴海莺，E-mail：smilewhy@126.com

中图分类号: R765
计量
- 文章访问数: 2538
- HTML全文浏览量: 2129
- PDF下载量: 18
- 被引次数: 0
出版历程
- 收稿日期: 2022-01-10
- 网络出版日期: 2022-07-21
- 刊出日期: 2022-07-28

Advances on Smad4 on Olfactory System Function and Disease

1.
Dept .of Otorhinolaryngology, The 2nd Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650101
2.
Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Biomedical Engineering Research Center, Kunming Medical University, Kunming Yunnan 650500, China

摘要

摘要: Smad4蛋白可与转化生长因子β（TGF-β）上的 TGF-β I 型受体（TβR I）相结合，并将其激活。目前已知TGF-β/Smads 信号通路在犁鼻感觉神经元（vomeronasal sensory neurons，VSN）的成熟、功能和精确连通性方面起着关键作用，Smad4的突变会导致后部副嗅球形成的异常，导致嗅觉传导异常。Smad4是公认的抑癌基因，其在癌细胞中的表达与正常组织具有显著差异。转化生长因子-β 通过其信号传导通路及其作用底物Smads 蛋白将生物信号由胞膜传至胞核激活相应核酸转录从而调控细胞的分化、增殖、粘附、迁移、凋亡，血管生成，免疫反应等。
- Smad4 /
- 嗅觉系统 /
- 鼻腔肿瘤 /
- 信息素
Abstract: Smad4 protein binds to the TGF-β type I receptor（TβR I） on transforming growth factor-β（TGF-β） and activates it. The TGF-β/Smads signaling pathway is known to play a key role in the maturation, function, and precise connectivity of vomeronasal sensory neurons（VSNs）. Mutations in Smad4 lead to abnormal formation of the posterior paraolfactory bulb, resulting in abnormal olfactory conduction. Smad4 is a recognized tumor suppressor gene, and its expression in malignant tumors is significantly different from normal tissues. TGF-β transmits biological signals from the cell membrane to the nucleus through its signal transduction pathway and its substrate Smads protein to activate transcription of nucleic acid; consequently, to regulate cell differentiation, proliferation, adhesion, migration, apoptosis, angiogenesis, and immune response.
- Smad4 /
- Olfactory system /
- Nasal tumor /
- Pheromones

HTML全文

参考文献(39)

[1]	姚方姝,陈科璞,周雯. 嗅觉新探索[J]. 科学世界,2019,20(5):100-105.
[2]	范晓清,杨铭. Smad4与胃癌关系的研究进展[J]. 当代医药论丛,2017,15(22):35-36. doi: 10.3969/j.issn.2095-7629.2017.22.022
[3]	Beltrán-Corbellini á,Chico-García JL,Martínez-Poles J,et al. Acute-onset smell and taste disorders in the context of COVID-19:A pilot multicentre polymerase chain reaction based case-control study[J]. Eur J Neurol,2020,27(9):1738. doi: 10.1111/ene.14273
[4]	Naik A S,Lin J M,Taroc E Z M,et al. Smad4 signaling establishes the somatosensory map of basal vomeronasal sensory neurons[J]. BioRxiv,2019,1(9):738393.
[5]	S Firestein. How the olfactory system makes sense of scents[J]. Nature,2001,413(6852):211-218. doi: 10.1038/35093026
[6]	Lapid H,Hummel T. Recording odor-evoked response potential at the human olfactory epithelium[J]. ChemSenses,2013,3(1):3-17.
[7]	Lin D Y,Zhang S Z,Block E,et a1. Encoding social signals in the mouse main olfactory bulb[J]. Nature,2005,434(3):470-477.
[8]	Brennan P A,Zufall F. Pheromonal communication in vertebrates[J]. Nature,2006,444(11):308-315.
[9]	Monti Bloch L,Grosser B I. Effect of putative pheromones on the electrical activity of the human vomeronasal organ and olfactory epithelium[J]. J Steroid Biochem Mol Biol,1991,39(4):573-582. doi: 10.1016/0960-0760(91)90255-4
[10]	Gower D B,Ruparelia B A. Olfaction in humans with special reference to odorous 16-androstenes:Their occurrence,perception and possible social,psychological and sexual impact[J]. J Endocrinol,1993,137(2):167-187. doi: 10.1677/joe.0.1370167
[11]	Thysen B,Elliott W H,Katzman P A. Identification of estra-l,3,5(10),16-tetraen-3-ol(estratetraenol)from the urine of pregnant women(1)[J]. Steroids,1968,11(1):73-87. doi: 10.1016/S0039-128X(68)80052-2
[12]	Wyart C,Webster W W,Chen J H,et al. Smelling a single component of male sweat alters levels of cortisol in women[J]. J Neurosci,2007,27(6):1261-1265. doi: 10.1523/JNEUROSCI.4430-06.2007
[13]	Lundstrom J N, Olsson M J. Subthreshold amounts of social odorant affect mood, but not behavior, in heterosexual women when tested by a male, but not a female, experimenter[J]. Biol Psychol, 2005, 70（3）: l 97-204.
[14]	Bensafi M,Brown W M,Tsutsui T,et a1. Sex-steroid derived compounds induce sex—specific effects on autonomic nervous system function in humans[J]. Behav Neurosci,2003,117(6):1125-1134. doi: 10.1037/0735-7044.117.6.1125
[15]	Grosser B I,Monti Bloch L,Jennings White C,et a1. Behavioral and electrophysiological effects of androstadienone,a humanpheromone[J]. Psychoneuroendocrinology,2000,25(3):289-299. doi: 10.1016/S0306-4530(99)00056-6
[16]	吴民耀,张凡,王宏元. 犁鼻器的结构和功能[J]. 动物医学进展,2012,33(01):111-114. doi: 10.3969/j.issn.1007-5038.2012.01.025
[17]	Zhao M,Mishra L,Deng C X. The role of TGF-β/SMAD4 signaling in cancer[J]. Int J Biol Sci,2018,14(2):111-123. doi: 10.7150/ijbs.23230
[18]	侯雪飞,杨铮,万崇华,等. 大肠癌患者报告结局、生命质量与基因关系的初步探讨[J]. 广东医科大学学报,2020,37(5):543-546,552. doi: 10.3969/j.issn.1005-4057.2020.05.007
[19]	A Rodewald,D Gisder,V M Gebhart,et al. Distribution of olfactory marker protein in the rat vomeronasal organ[J]. Journal of Chemical Neuroanatomy,2016,77(5):19-23.
[20]	Naik Ankana S,Lin Jennifer M,Taroc E d Zandro M,et al. Smad4-dependent morphogenic signals control the maturation and axonal targeting of basal vomeronasal sensory neurons to the accessory olfactory bulb.[J]. Development (Cambridge,England),2020,147(8):184036.
[21]	Noguchi Tomohiro,Miyazono Sadaharu,Kashiwayanagi Makoto. Stimulus dynamics-dependent information transfer of olfactory and vomeronasal sensory neurons in mice.[J]. Neuroscience,2018,4(12):5.
[22]	Chen K,Ye Y,Troje N F,et al. Oxytocin modulates human chemosensory decoding of sex in a dose-dependent manner[J]. ELife,2021,10(1):59376. doi: 10.7554/eLife.59376
[23]	叶玉婷,陈科璞,周雯. 信息素影响人类行为吗?[J]. 科学通报,2016,61(13):1389-1394.
[24]	Pause B M,Ohrt A,Prehn A,et a1. Positive emotional priming of facial affect perception in females is diminished by chemosensory anxiety signals[J]. Chem Senses,2004,29(9):797-805. doi: 10.1093/chemse/bjh245
[25]	Prehn A,Ohrt A,Sojka B,et a1. Chemosensory anxiety signals augment the startle reflex in humans[J]. Neurosci Lett,2006,394(2):127-130. doi: 10.1016/j.neulet.2005.10.012
[26]	Zhou W. Chen D. Fear-related chemosignals modulate recognition of fear in ambiguous facial expressions[J]. Psychol Sci,2009,20:177-183. doi: 10.1111/j.1467-9280.2009.02263.x
[27]	De Groot J H,Smeets M A,Kaldewaij A,et a1. Chemosignals communicate human emotions[J]. Psychol Sci,2012,23(11):1417-1424. doi: 10.1177/0956797612445317
[28]	Parma V,Tirindelli R,Bisazza A,et a1. Subliminally perceived odours modulate female intrasexual competition:An eye movement study[J]. PLoS One,2012,7(2):30645. doi: 10.1371/journal.pone.0030645
[29]	Gelstein S,Yeshurun Y,Rozenkrantz L,et a1. Human tears contain a chemosignal[J]. Science,2011,331(6014):226-230. doi: 10.1126/science.1198331
[30]	Sarah M,Joshua J,Sean K,et al. Smad4 loss promotesung cancer formation but increases sensitivity to DNA topoisomerase inhibitors[J]. Oncogene,2016,35(5):577-586. doi: 10.1038/onc.2015.112
[31]	Demagny H,De Robertis E M. Point mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-beta signaling[J]. Mol Cell Oncol,2016,3(1):1025181. doi: 10.1080/23723556.2015.1025181
[32]	方凌凌. LAMC1及PLAU调控微环境中CAF的活化及促进食管鳞癌进展的机制研究[D]. 北京: 北京协和医院博士学位论文, 2021.
[33]	陈海燕, 郝敏, 王志莲. Smad4与女性生殖系统恶性肿瘤关系的研究进展[J/CD]. 中华妇幼临床医学杂志, 2016, 12（3）: 349-353.
[34]	Mackenzie R,Kommoss S,Winterhoff B J,et al. Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping AS pathway activating mutations in borderline and cancerous neoplasms[J]. BMC Cancer,2015,15(5):415.
[35]	V á zquez P F,Carlini M J,Daroqui M C,et al. TGF-β specifically enhances the metastatic attributes of murine lung adenocarcinoma:implications for human non-small cell lung cancer[J]. Clin Exp Metastasis,2013,30(8):993-1007. doi: 10.1007/s10585-013-9598-1
[36]	Lei Z,Xu G,Wang L,et al. MiR-142-3p represses TGF-β-induced growth inhibition through repression of TGFβR1 in non-small cell lung cancer[J]. FASEB J,2014,28(6):2696-2704. doi: 10.1096/fj.13-247288
[37]	刘剑锋,杨大章. 鼻-鼻颅底恶性肿瘤的治疗进展[J]. 中国耳鼻咽喉颅底外科杂志,2017,23(6):501-508.
[38]	吴林林,刘红刚. 嗅神经母细胞瘤临床病理特征与治疗的研究进展[J]. 诊断病理学杂志,2021,28(2):124-127. doi: 10.3969/j.issn.1007-8096.2021.02.011
[39]	Topcagic J,Feldman R,Ghazalpour A,et al. Comprehensive molecular profiling of advanced/metastatic olfactory neuroblastomas[J]. PLoS One,2018,13(1):191,244.

相关文章(20)

[1]	马丽, 周玉娥, 蒋佳慧, 李军瑶, 穆晓燕, 马懿. 嗅觉安抚联合母亲音频刺激对住院早产儿睡眠情况的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240827
[2]	杨敏, 林琪琪, 刘丹丹, 周宏宇. 水仙环素的抗肿瘤活性及机制研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240222
[3]	杨诗瑶, 杨艳霞, 杨海银, 董勇, 苗金虎, 朱悦熙, 关琼瑶. 成人肿瘤患者跌倒发生率及影响因素的系统评价, 昆明医科大学学报.
[4]	吕煜, 胡义波, 王嘉鑫, 苏有橦, 代佑果. 蛋白质S-亚硝基化与消化系统肿瘤关系的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220911
[5]	陈紫红, 刘红, 刘明伟, 舒密, 南琼. MiRNA-145在消化系统恶性肿瘤中的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210334
[6]	陈鹏, 阳锡军, 李春满, 刘锋, 阿永俊. 槲皮素对裸鼠肝癌切除术后肿瘤复发的影响及机制, 昆明医科大学学报.
[7]	王春龙, 韩丹, 文亮. 间皮素与肿瘤诊治的相关研究进展, 昆明医科大学学报.
[8]	赵小琳. 调控内源性大麻素系统对酒精性肝细胞损伤模型的影响, 昆明医科大学学报.
[9]	廖然超. 鼻腔蝇蛆病1例报道, 昆明医科大学学报.
[10]	江超武. 鼻腔鼻窦神经内分泌癌诊治与预后分析, 昆明医科大学学报.
[11]	杜兴华. ALX4基因在肿瘤中的甲基化与表达, 昆明医科大学学报.
[12]	刘建军. 人肿瘤抗原基因Delta-like4(DLL4）可溶性表达、纯化及鉴定, 昆明医科大学学报.
[13]	李瑞. CIK细胞治疗泌尿系统恶性肿瘤的护理体会, 昆明医科大学学报.
[14]	杨丽华. 抗整合素αⅤβ3单抗抑制上皮性卵巢癌血管及肿瘤生成的实验研究, 昆明医科大学学报.
[15]	李玉晓. 大蒜新素对变应性鼻炎患者外周血白介素4和γ干扰素的影响, 昆明医科大学学报.
[16]	孙涛. 眶上锁孔入路显微手术治疗前颅窝底肿瘤4例报告, 昆明医科大学学报.
[17]	马云. 肠系膜脂膜炎误诊为结肠肿瘤病4例分析报道, 昆明医科大学学报.
[18]	解燕华. CIK细胞治疗泌尿系统肿瘤的临床疗效分析, 昆明医科大学学报.
[19]	. 深低温停循环对大鼠额叶皮质Smad2和Smad4表达的影响, 昆明医科大学学报.
[20]	邓德耀. 实验室信息系统中检验申请信息录入错误的调查分析, 昆明医科大学学报.