Smad4与嗅觉系统功能及疾病的研究进展

张切; 王淑芬; 曹守明; 吴海莺

doi:10.12259/j.issn.2095-610X.S20220826

Smad4与嗅觉系统功能及疾病的研究进展

doi: 10.12259/j.issn.2095-610X.S20220826

1.
昆明医科大学第二附属医院耳鼻咽喉科, 云南昆明　650101
2.
昆明医科大学生物医学工程研究中心云南省干细胞和再生医学重点实验室, 云南昆明　650500

基金项目: 国家自然科学基金资助项目（81960240，31460314）;　云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202001AY070001-001，202201AY070001-122）

详细信息

作者简介:
张切（1995～），男，湖北随州人，在读硕士研究生，主要从事鼻颅底及嗅觉障碍临床与基础研究工作

通讯作者:
吴海莺，E-mail：smilewhy@126.com

中图分类号: R765
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- 文章访问数: 2565
- HTML全文浏览量: 2135
- PDF下载量: 18
- 被引次数: 0
出版历程
- 收稿日期: 2022-01-10
- 网络出版日期: 2022-07-21
- 刊出日期: 2022-07-28

Advances on Smad4 on Olfactory System Function and Disease

1.
Dept .of Otorhinolaryngology, The 2nd Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650101
2.
Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Biomedical Engineering Research Center, Kunming Medical University, Kunming Yunnan 650500, China

摘要

摘要: Smad4蛋白可与转化生长因子β（TGF-β）上的 TGF-β I 型受体（TβR I）相结合，并将其激活。目前已知TGF-β/Smads 信号通路在犁鼻感觉神经元（vomeronasal sensory neurons，VSN）的成熟、功能和精确连通性方面起着关键作用，Smad4的突变会导致后部副嗅球形成的异常，导致嗅觉传导异常。Smad4是公认的抑癌基因，其在癌细胞中的表达与正常组织具有显著差异。转化生长因子-β 通过其信号传导通路及其作用底物Smads 蛋白将生物信号由胞膜传至胞核激活相应核酸转录从而调控细胞的分化、增殖、粘附、迁移、凋亡，血管生成，免疫反应等。
- Smad4 /
- 嗅觉系统 /
- 鼻腔肿瘤 /
- 信息素
Abstract: Smad4 protein binds to the TGF-β type I receptor（TβR I） on transforming growth factor-β（TGF-β） and activates it. The TGF-β/Smads signaling pathway is known to play a key role in the maturation, function, and precise connectivity of vomeronasal sensory neurons（VSNs）. Mutations in Smad4 lead to abnormal formation of the posterior paraolfactory bulb, resulting in abnormal olfactory conduction. Smad4 is a recognized tumor suppressor gene, and its expression in malignant tumors is significantly different from normal tissues. TGF-β transmits biological signals from the cell membrane to the nucleus through its signal transduction pathway and its substrate Smads protein to activate transcription of nucleic acid; consequently, to regulate cell differentiation, proliferation, adhesion, migration, apoptosis, angiogenesis, and immune response.
- Smad4 /
- Olfactory system /
- Nasal tumor /
- Pheromones

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