Smad4与嗅觉系统功能及疾病的研究进展

张切; 王淑芬; 曹守明; 吴海莺

doi:10.12259/j.issn.2095-610X.S20220826

Smad4与嗅觉系统功能及疾病的研究进展

doi: 10.12259/j.issn.2095-610X.S20220826

1.
昆明医科大学第二附属医院耳鼻咽喉科, 云南昆明　650101
2.
昆明医科大学生物医学工程研究中心云南省干细胞和再生医学重点实验室, 云南昆明　650500

基金项目: 国家自然科学基金资助项目（81960240，31460314）;　云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202001AY070001-001，202201AY070001-122）

详细信息

作者简介:
张切（1995～），男，湖北随州人，在读硕士研究生，主要从事鼻颅底及嗅觉障碍临床与基础研究工作

通讯作者:
吴海莺，E-mail：smilewhy@126.com

中图分类号: R765
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- 文章访问数: 2136
- HTML全文浏览量: 1738
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- 被引次数: 0
出版历程
- 收稿日期: 2022-01-10
- 网络出版日期: 2022-07-21
- 刊出日期: 2022-07-28

Advances on Smad4 on Olfactory System Function and Disease

1.
Dept .of Otorhinolaryngology, The 2nd Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650101
2.
Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Biomedical Engineering Research Center, Kunming Medical University, Kunming Yunnan 650500, China

摘要

摘要: Smad4蛋白可与转化生长因子β（TGF-β）上的 TGF-β I 型受体（TβR I）相结合，并将其激活。目前已知TGF-β/Smads 信号通路在犁鼻感觉神经元（vomeronasal sensory neurons，VSN）的成熟、功能和精确连通性方面起着关键作用，Smad4的突变会导致后部副嗅球形成的异常，导致嗅觉传导异常。Smad4是公认的抑癌基因，其在癌细胞中的表达与正常组织具有显著差异。转化生长因子-β 通过其信号传导通路及其作用底物Smads 蛋白将生物信号由胞膜传至胞核激活相应核酸转录从而调控细胞的分化、增殖、粘附、迁移、凋亡，血管生成，免疫反应等。
- Smad4 /
- 嗅觉系统 /
- 鼻腔肿瘤 /
- 信息素
Abstract: Smad4 protein binds to the TGF-β type I receptor（TβR I） on transforming growth factor-β（TGF-β） and activates it. The TGF-β/Smads signaling pathway is known to play a key role in the maturation, function, and precise connectivity of vomeronasal sensory neurons（VSNs）. Mutations in Smad4 lead to abnormal formation of the posterior paraolfactory bulb, resulting in abnormal olfactory conduction. Smad4 is a recognized tumor suppressor gene, and its expression in malignant tumors is significantly different from normal tissues. TGF-β transmits biological signals from the cell membrane to the nucleus through its signal transduction pathway and its substrate Smads protein to activate transcription of nucleic acid; consequently, to regulate cell differentiation, proliferation, adhesion, migration, apoptosis, angiogenesis, and immune response.
- Smad4 /
- Olfactory system /
- Nasal tumor /
- Pheromones

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Smad4与嗅觉系统功能及疾病的研究进展

doi: 10.12259/j.issn.2095-610X.S20220826

作者简介:
张切（1995～），男，湖北随州人，在读硕士研究生，主要从事鼻颅底及嗅觉障碍临床与基础研究工作

通讯作者:
吴海莺，E-mail：smilewhy@126.com

计量

Advances on Smad4 on Olfactory System Function and Disease

计量

目录

[1]	杨敏, 林琪琪, 刘丹丹, 周宏宇. 水仙环素的抗肿瘤活性及机制研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240222
[2]	吕煜, 胡义波, 王嘉鑫, 苏有橦, 代佑果. 蛋白质S-亚硝基化与消化系统肿瘤关系的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220911
[3]	陈紫红, 刘红, 刘明伟, 舒密, 南琼. MiRNA-145在消化系统恶性肿瘤中的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210334
[4]	陈鹏, 阳锡军, 李春满, 刘锋, 阿永俊. 槲皮素对裸鼠肝癌切除术后肿瘤复发的影响及机制, 昆明医科大学学报.
[5]	王春龙, 韩丹, 文亮. 间皮素与肿瘤诊治的相关研究进展, 昆明医科大学学报.
[6]	赵小琳. 调控内源性大麻素系统对酒精性肝细胞损伤模型的影响, 昆明医科大学学报.
[7]	廖然超. 鼻腔蝇蛆病1例报道, 昆明医科大学学报.
[8]	杨小蕾. 系统性红斑狼疮患者STAT4基因mRNA和血清中IL-12、IFN-γ的表达, 昆明医科大学学报.
[9]	江超武. 鼻腔鼻窦神经内分泌癌诊治与预后分析, 昆明医科大学学报.
[10]	江超武. 鼻腔鼻窦神经内分泌癌诊治与预后分析, 昆明医科大学学报.
[11]	杜兴华. ALX4基因在肿瘤中的甲基化与表达, 昆明医科大学学报.
[12]	刘建军. 人肿瘤抗原基因Delta-like4(DLL4）可溶性表达、纯化及鉴定, 昆明医科大学学报.
[13]	李瑞. CIK细胞治疗泌尿系统恶性肿瘤的护理体会, 昆明医科大学学报.
[14]	杨丽华. 抗整合素αⅤβ3单抗抑制上皮性卵巢癌血管及肿瘤生成的实验研究, 昆明医科大学学报.
[15]	李玉晓. 大蒜新素对变应性鼻炎患者外周血白介素4和γ干扰素的影响, 昆明医科大学学报.
[16]	孙涛. 眶上锁孔入路显微手术治疗前颅窝底肿瘤4例报告, 昆明医科大学学报.
[17]	马云. 肠系膜脂膜炎误诊为结肠肿瘤病4例分析报道, 昆明医科大学学报.
[18]	解燕华. CIK细胞治疗泌尿系统肿瘤的临床疗效分析, 昆明医科大学学报.
[19]	. 深低温停循环对大鼠额叶皮质Smad2和Smad4表达的影响, 昆明医科大学学报.
[20]	邓德耀. 实验室信息系统中检验申请信息录入错误的调查分析, 昆明医科大学学报.

留言板

Smad4与嗅觉系统功能及疾病的研究进展

doi: 10.12259/j.issn.2095-610X.S20220826

作者简介: 张切（1995～），男，湖北随州人，在读硕士研究生，主要从事鼻颅底及嗅觉障碍临床与基础研究工作

通讯作者: 吴海莺，E-mail：smilewhy@126.com

计量

出版历程

Advances on Smad4 on Olfactory System Function and Disease

计量

出版历程

目录

作者简介:
张切（1995～），男，湖北随州人，在读硕士研究生，主要从事鼻颅底及嗅觉障碍临床与基础研究工作

通讯作者:
吴海莺，E-mail：smilewhy@126.com