新型冠状病毒感染相关口腔损害

赵汉青; 钱石兵; 王孟琪; 杨镕羽; 段开文

doi:10.12259/j.issn.2095-610X.S20220831

新型冠状病毒感染相关口腔损害

doi: 10.12259/j.issn.2095-610X.S20220831

昆明医科大学附属延安医院口腔科，云南昆明　650051

基金项目: 国家自然科学基金资助项目（81160135）

详细信息

作者简介:
赵汉青（1996~），男，陕西咸阳人，在读硕士研究生，主要从事牙周病及口腔黏膜病防治工作

通讯作者:
段开文，E-mail：kwduan@aliyun.com

中图分类号: R780.1
计量
- 文章访问数: 3942
- HTML全文浏览量: 2140
- PDF下载量: 29
- 被引次数: 0
出版历程
- 收稿日期: 2022-02-26
- 网络出版日期: 2022-03-15
- 刊出日期: 2022-07-28

Oral Lesions Associated with 2019-nCoV

Dept. of Stomatology，Yan’an Hospital Affiliated to Kunming Medical University， Kunming Yunnan 650051，China

摘要

摘要: 新型冠状病毒是2019年底开始流行全球的传染病（COVID-19）-新型冠状病毒病的病原体，对人体呼吸道为主的多个器官造成损伤，口腔损害被认为也是该病常见表现。分析2019年12月至2021年11月期间发表的有关新冠病毒感染与口腔表现文献，总结COVID-19相关口腔损害特征及其可能机制。发现所报告的病例中口腔病变以味觉功能障碍、口干症和溃疡性损害等多见。口腔病损发病机制尚未完全清楚，但口腔上皮细胞广发存在2019-nCoV进入细胞受体ACE2，病毒复制并可能造成组织炎症和破坏是基本的致病机制。
- 新型冠状病毒 /
- 新型冠状病毒病 /
- 口腔黏膜损害 /
- 牙周病
Abstract: COVID-19 virus is the pathogen of the new type of corona virus disease 2019, a global infectious disease that began to spread at the end of 2019. It has caused damage to multiple organs particularly human respiratory tract. Oral lesions is considered to be a common manifestation of this disease. This article summarized the characteristics and possible mechanisms of COVID-19 related oral damage in novel coronavirus infections and oral manifestations from publications between December 2019 and November 2021. It showed that the oral manifestations of the reported cases were mainly gustatory dysfunction, xerostomia and ulcerative lesions. The mechanism of oral lesions is not yet fully understood, but 2019-nCoV enters the cell receptor ACE2 widely in oral epithelial cells. Virus replication and possible tissue inflammation and destruction could be its possible pathogenic mechanisms.
- Coronavirus 2019 /
- COVID-19 /
- Oral mucosal lesions /
- Periodontal disease

HTML全文

参考文献(27)

[1]	王业明,徐逸天,曹彬. 新型冠状病毒感染传播、发病机制、诊断和治疗的进展[J]. 中华结核和呼吸杂志,2021,44(7):684-688. doi: 10.3760/cma.j.cn112147-20201120-01106
[2]	Lu R,Zhao X,Li J,et al. Genomic characterisation and epidemiology of 2019 novel coronavirus:Implications for virus origins and receptor binding[J]. Lancet Lond Engl,2020,3959(3):565-574.
[3]	Chen L,Zhao J,Peng J,et al. Detection of SARS-CoV-2 in saliva and characterization of oral symptoms in COVID-19 patients[J]. Cell Prolif,2020,53(12):12923.
[4]	Hindson J. COVID-19:Faecal–oral transmission?[J]. Nature Reviews Gastroenterology &Hepatology,2020,17(5):259.
[5]	To K K,Tsang O T,YipC C,et al. Consistent detection of 2019 novel coronavirus in saliva[J]. Clin Infect Dis,2020,71(5):841-843.
[6]	Xu H,Zhong L,Deng J,et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa[J]. Int J Oral Sci,2020,12(1):8. doi: 10.1038/s41368-020-0074-x
[7]	Tay M Z,Poh C M,Rea L,et al. The trinity of COVID‐19:immunity,inflammation and intervention[J]. Nat Rev Immunol,2020,20(6):363-374.
[8]	Sapkota D,Søland T M,Galtung H K,et al. COVID-19 salivary signature:Diagnostic and research opportunities[J]. J Clin Pathol,2020,74(6):344-349.
[9]	Santos J A,Normando A G C,Carvalho da Silva R L,et al. Oral mucosal lesions ina COVID‐19 patient:New signs or secondary manifestations?[J]. Int J Infect Dis,2020,97(2):326-328.
[10]	Mullol J,Alobid I,Marino-Sanchez F,et al. The loss of smell and taste in the COVID-19 outbreak:A tale of many countries[J]. Curr Allergy Asthma Rep,2020,20(10):61. doi: 10.1007/s11882-020-00961-1
[11]	Benazzo M,Cassaniti I,Maiorano E,et al. SARS‐CoV‐2 virologic and immunologic correlates in patients with olfactory and taste disorders[J]. Microorganisms,2020,8(7):1052. doi: 10.3390/microorganisms8071052
[12]	MarinoSanchez F,SantamariaGadea A,De Los Santos G,et al. Psychophysical olfactory testing in COVID-19:Is smell function really impaired in nearly all patients?[J]. Int Forum Allergy Rhinol,2020,10(8):951-952.
[13]	Sakaguchi W,Kubota N,Shimizu T,et al. Existence of SARS-CoV-2 entry molecules in the oral cavity[J]. Int J Mol Sci,2020,21(17):6000. doi: 10.3390/ijms21176000
[14]	Finsterer J,Stollberger C. Causes of hypogeusia/hyposmia in SARS-CoV2 infected patients[J]. J Med Virol,2020,92(12):1793-1794.
[15]	Jothimani D,Kailasam E,Danielraj S,et al. COVID-19:Poor outcomes in patients with zinc deficiency[J]. Int J Infect Dis,2020,100(3):343-349.
[16]	Favia G,Tempesta A,Barile G,et al. Covid-19 symptomatic patients with oral lesions:Clinical and histopathological study on 123 cases of the university hospital policlinic of bari with a purpose of a new classification[J]. J Clin Med,2021,10(4):757. doi: 10.3390/jcm10040757
[17]	Gherlone E F,Polizzi E,Tete G,et al. Frequent and persistent salivary gland ectasia and oral disease after COVID-19[J]. J Dent Res,2021,100(5):464-471. doi: 10.1177/0022034521997112
[18]	Farshidfar N, Hamedani S. Hyposalivation as a potential risk for SARS-CoV-2 infection: Inhibitory role of saliva[J]. Oral Dis, 2020, 27（Suppl 3）: 750-751.
[19]	Biadsee A,Kassem F,Dagan O,et al. Olfactory and oral manifestations of COVID-19:Sex-related symptoms-A potential pathway to early diagnosis[J]. Otolaryngol Head Neck Surg,2020,163(4):722-728. doi: 10.1177/0194599820934380
[20]	Hockova B,Riad A,Valky J,et al. Oral Complications of ICU patients with COVID-19:Case-series and review of two hundred tencases[J]. J Clin Med,2021,10(4):581. doi: 10.3390/jcm10040581
[21]	Iranmanesh B,Khalili M,Amiri R,et al. Oral manifestations of COVID-19 disease:A review article[J]. Dermatol Ther,2021,34(1):14578.
[22]	Riad A,Gomaa E,Hockova B,et al. Oral candidiasis of COVID-19 patients:Case report and review of evidence[J]. J CosmetDermatol,2021,20(6):1580-1584.
[23]	Le Balch P,Pinceaux K,Pronier C,et al. Herpes simplex virus and cytomegalovirus reactivations among severe COVID-19 patients[J]. Crit Care,2020,24(1):530. doi: 10.1186/s13054-020-03252-3
[24]	Burgos Ponce J, Trijoe K C. Overlapping findings or oral manifestations in new SARS- CoV-2 infection[J]. Oral Dis, 2020 , 27 （Suppl 3）: 781-782.
[25]	Patel J, Woolley J. Necrotizing periodontal disease: Oral manifestation of COVID‐19[J]. Oral Dis, 2021, 27 （Suppl 3）: 768-769.
[26]	Anand P S,Jadhav P,Kamath K P,et al. A case-control study on the association between periodontitis and coronavirus disease (COVID-19)[J]. J Periodontol,2021,18(1):1-7.
[27]	Halepas S,Lee K C,Myers A,et al. Oral manifestations of COVID-2019-related multisystem inflammatory syndrome in children:A review of 47 pediatric patients[J]. J Am Dent Assoc,2021,152(3):202-208. doi: 10.1016/j.adaj.2020.11.014

相关文章(20)

[1]	吕松琴, 黄山, 马礼堂, 王秀, 张洪涛, 李钦, 万春平, 吕正超. 云南地区HIV/AIDS人群新型冠状病毒疫苗接种情况及接种意愿的调查, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240108
[2]	何海萍. 新型冠状病毒肺炎的老年患者的凝血功能指标分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240414
[3]	黄瑛, 罗云, 武彦, 刘冰, 江姗, 何花. 新型冠状病毒感染者咽拭子与粪便排毒规律及临床表现, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220112
[4]	王芳, 赵蓉, 郑虹. 康复新联合蒙脱石散防治放射性口腔黏膜炎的临床疗效, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210626
[5]	殷顺会, 周建忠, 李自良. Tiger17促进口腔黏膜成纤维细胞的增殖和迁移, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210823
[6]	段婷婷, 吕娅, 潘蕊, 王莉, 田莹. 集束化护理方案在预防急性白血病化疗所致口腔黏膜炎中的效果, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210108
[7]	吴莉, 杨云辉, 张靖, 杨章聪, 苏宇, 温勇坚, 吴玉春, 王鹏, 李志鹏, 赵卫, 韩丹, 王瑞东, 何波. 输入性新型冠状病毒肺炎首诊影像学特点与临床严重度分级的相关性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210708
[8]	丁慧, 姚兰. 云南省农村65～74岁老年人牙周状况及其相关因素, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210407
[9]	杨云辉, 何波, 游顶云, 杨俊涛, 高茜. CT在早期预测新型冠状病毒肺炎不同临床分型的应用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210524
[10]	彭思思, 丁慧, 马丽娅, 吕扬, 段彦好, 阳磊, 张石楠. 昆明市大学生口腔健康状况调查, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210624
[11]	李欢, 徐秋月, 王云娟, 苏洋, 唐睿珠. 利用逆转录环介导恒温扩增技术建立新型冠状病毒核酸快速检测方法, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210904
[12]	王亚洲, 黄芩, 李小明, 张笃飞, 韦焘. 川崎病冠状动脉损害与发热持续时间的相关性, 昆明医科大学学报.
[13]	古利明, 曾勇, 陈俊辉, 王福平, 郝应禄, 吴海鹰, 阮继银, 李燕皎, 陈云, 夏婧, 孙佳, 胡隽源, 李薇, 余从涛, 马朝霞, 钱传云, 胡敏. 人脐带间充质干细胞联合抗病毒等方法治疗新型冠状病毒肺炎, 昆明医科大学学报.
[14]	马志强, 王霖, 罗煜, 瞿春燕, 李保萍, 马云珊, 董睿, 吴艳蓉, 赵金花, 许娅琳. COVID-19患者粪便核酸检测结果特征及其临床意义, 昆明医科大学学报.
[15]	叶文君, 王瑞珩, 曾小菊, 刘卫青, 刘芳. 新型冠状病毒肺炎时期普通人群的正念减压, 昆明医科大学学报.
[16]	袁宇, 李翔. 2019型冠状病毒病之心肌损害述评, 昆明医科大学学报.
[17]	何红, 张婉丽, 李星星, 牛涛, 李红云. 固定式恒久性牙周夹板的临床应用, 昆明医科大学学报.
[18]	彭艺. 云南临沧480名拉祜族居民口腔健康调查, 昆明医科大学学报.
[19]	税艳青. 牙周病相关研究及组织工程应用的研究进展, 昆明医科大学学报.
[20]	普冬. AIDS 患者CD4水平及病毒载量与口腔念珠菌之间的关系, 昆明医科大学学报.