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人类胎盘的葡萄糖转运机制及GDM对胎盘葡萄糖转运的影响

何银东 张峻 黄桦 柳汝明 王茜

何银东, 张峻, 黄桦, 柳汝明, 王茜. 人类胎盘的葡萄糖转运机制及GDM对胎盘葡萄糖转运的影响[J]. 昆明医科大学学报, 2022, 43(9): 160-165. doi: 10.12259/j.issn.2095-610X.S20220903
引用本文: 何银东, 张峻, 黄桦, 柳汝明, 王茜. 人类胎盘的葡萄糖转运机制及GDM对胎盘葡萄糖转运的影响[J]. 昆明医科大学学报, 2022, 43(9): 160-165. doi: 10.12259/j.issn.2095-610X.S20220903
Yindong HE, Jun ZHANG, Hua HUANG, Ruming LIU, Xi WANG. Glucose Transport in Human Placenta and the Effect of GDM on Placental Glucose Transport[J]. Journal of Kunming Medical University, 2022, 43(9): 160-165. doi: 10.12259/j.issn.2095-610X.S20220903
Citation: Yindong HE, Jun ZHANG, Hua HUANG, Ruming LIU, Xi WANG. Glucose Transport in Human Placenta and the Effect of GDM on Placental Glucose Transport[J]. Journal of Kunming Medical University, 2022, 43(9): 160-165. doi: 10.12259/j.issn.2095-610X.S20220903

人类胎盘的葡萄糖转运机制及GDM对胎盘葡萄糖转运的影响

doi: 10.12259/j.issn.2095-610X.S20220903
基金项目: 国家自然科学基金资助项目(82160297,H0416);云南省高层次卫生计生技术人才培养专项基金资助项目(L-201614,H-2018077,H-201705,H-2018081);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2019FE001(-200),2018FE001(-167),202001AY070001-045,2018FE001(-310)]
详细信息
    作者简介:

    何银东(1997~),女,云南保山人,在读硕士研究生,主要从事妊娠期糖尿病患者治疗药物安全性相关的研究工作

    通讯作者:

    王茜,E-mail:crynner@126.com

  • 中图分类号: R713.1

Glucose Transport in Human Placenta and the Effect of GDM on Placental Glucose Transport

  • 摘要: 胎盘是将母体葡萄糖转运至子体的重要器官,正常的胎盘结构和功能为胎儿从母体有效摄取葡萄糖提供保障。胎盘上葡萄糖转运主要依赖于胎盘上的葡萄糖转运体(glucose transporters,GLUTs)。此外,胎盘自身对葡萄糖代谢也会影响经胎盘的葡萄糖转运。妊娠期糖尿病(gestational diabetes mellitus,GDM)是一种常见的妊娠期并发症。GDM患者胎盘上葡萄糖转体运功能的异常,可能是造成其子代产生不良结局的原因之一。就正常胎盘上的葡萄糖转运进行论述,并且探讨GDM患者胎盘上葡萄糖转运的改变及可能的分子机制。
  • 图  1  胎盘上的葡萄糖转运简图[1]

    注:Kmi :葡萄糖的胞间转运米氏常数;Kmo :葡萄糖的胞外转运米氏常数; [glucose] :葡萄糖浓度。葡萄糖通过GLUTs从血糖浓度较高的母体侧扩散到血糖浓度较低的胎儿侧。母体侧血糖浓度从动脉到静脉依次是[glucose] A > [glucose ]B > [glucose] C > > [glucose] H,胎盘各个区域的葡萄糖浓度由母体侧转运进来的血糖和各个区域向胎儿侧扩散的葡萄糖共同决定。

    Figure  1.  Transplacental glucose transport

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  • 收稿日期:  2022-06-09
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