蛋白质S-亚硝基化与消化系统肿瘤关系的研究进展

吕煜; 胡义波; 王嘉鑫; 苏有橦; 代佑果

doi:10.12259/j.issn.2095-610X.S20220911

蛋白质S-亚硝基化与消化系统肿瘤关系的研究进展

doi: 10.12259/j.issn.2095-610X.S20220911

1.
浙江省人民医院/杭州医学院附属人民医院急诊科，浙江杭州　310014
2.
昆明医科大学第三附属医院/云南省肿瘤医院/云南省癌症中心胃与小肠外科，云南昆明　650118
3.
姑息医学科，云南昆明　650118

基金项目: 国家自然科学基金资助项目（82001986）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（2018FE001-064）；昆明医科大学创新基金资助项目（2021S240，2022S304）

详细信息

作者简介:
吕煜（1992～），女，黑龙江鸡西人，医学硕士，住院医师，主要从事急诊及消化道肿瘤的防治与治疗基础研究工作

通讯作者:
代佑果，E-mail： daiyouguo@126.com

中图分类号: R735
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- 被引次数: 0
出版历程
- 收稿日期: 2022-06-11
- 刊出日期: 2022-09-25

Advances on the Relationship between Protein S-nitrosylation and Digestive System Tumors

1.
Dept. of Emergency Medicine，Zhejiang Provincial People’s Hospital/Affiliated People’s Hospital，Hangzhou Medical College of Hangzhou Zhejiang 310014
2.
Dept. of Gastrointestinal Surgery
3.
Dept. of Palliative Medicine，The 3rd Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital/Yunnan Cancer Center，Kunming Yunnan 650118，China

摘要

摘要: S-亚硝基化修饰是由高浓度一氧化氮（NO）对蛋白质进行选择性的可逆性翻译后修饰，与多种细胞过程和组织稳态有关。大多消化系统肿瘤与炎症发展相互作用，炎症状态下机体诱导大量NO产生，NO具有使底物蛋白S-亚硝基化修饰的作用。目前已发现多种癌组织中蛋白的S-亚硝基化表达异常，回顾国内外相关研究，S-亚硝基化与肿瘤发生发展关系已成为当下研究热点。简述了蛋白质S-亚硝基化失衡在不同消化系统肿瘤中发生发展以及治疗中的作用机制，得出在不同消化系统肿瘤中S-亚硝基化失衡可以通过不同蛋白质的S-亚硝基化促进或抑制肿瘤的发展，旨在挖掘消化系统肿瘤中S-亚硝基化水平的治疗潜力。
- 蛋白质 /
- S-亚硝基化 /
- 一氧化氮 /
- 消化系统肿瘤
Abstract: S-nitrosylation modification is a selective and reversible post-translational modification of protein by high concentration of nitric oxide （NO）, which is related to a variety of cellular processes and tissue homeostasis. Most digestive system tumors interact with the development of inflammation. The body induces a great deal of NO in an inflammatory state and NO can modify the substrate protein S-nitrosylation. At present, it has been found that the expression of S-nitrosylation of proteins in a variety of cancer tissues is abnormal. Relevant studies at home and abroad show that the relationship between S-nitrosylation and tumor occurrence and development has become a current research focus. By briefly describing the mechanism of protein S-nitrosylation imbalance in the occurrence and development of different digestive system tumors and treatments,this review concludes that S-nitrosylation imbalance in different digestive system tumors can promote or inhibit the development of tumors through the S-nitrosylation of different proteins and aims to tap the therapeutic potential of S-nitrosylation level in digestive system tumors.
- Protein /
- S-nitrosylation /
- Nitric oxide /
- Digestive system tumor

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参考文献(37)

[1]	Król M,Kepinska M. Human nitric oxide synthase-its functions,polymorphisms,and inhibitors in the context of inflammation[J]. Int J Mol Sci,2020,22(1):56. doi: 10.3390/ijms22010056
[2]	Singh N,Baby D,Rajguru J P,et al. Inflammation and cancer[J]. Ann Afr Med,2019,18(3):121-126. doi: 10.4103/aam.aam_56_18
[3]	Suarez Carmona M,Lesage J,Cataldo D,et al. EMT and inflammation:Inseparable actors of cancer progression[J]. Mol Oncol,2017,11(7):805-823. doi: 10.1002/1878-0261.12095
[4]	Khan F H,Dervan E,Bhattacharyya D D,et al. The role of nitric oxide in cancer:Master regulator or not?[J]. Int J Mol Sci,2020,21(24):9393. doi: 10.3390/ijms21249393
[5]	Hu Y, Xiang J, Su L, et al. The regulation of nitric oxide in tumor progression and therapy [J]. Int J Appl Basic Med Res, 2020, 48（2）: 300060520905985.
[6]	Mnatsakanyan R,Markoutsa S,Walbrunn K,et al. Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique[J]. Nat Commun,2019,10(1):2195. doi: 10.1038/s41467-019-10182-4
[7]	Chang H C,Guarente L. SIRT1 and other sirtuins in metabolism[J]. Trends Endocrinol Metab,2014,25(3):138-145. doi: 10.1016/j.tem.2013.12.001
[8]	Kane A E,Sinclair D A. Sirtuins and NAD(+) in the development and treatment of metabolic and cardiovascular diseases[J]. Circ Res,2018,123(7):868-885. doi: 10.1161/CIRCRESAHA.118.312498
[9]	Ong A L C,Ramasamy T S. Role of Sirtuin1-p53 regulatory axis in aging,cancer and cellular reprogramming[J]. Ageing Res Rev,2018,43(5):64-80.
[10]	Rezk N A,Lashin M B,Sabbah N A. MiRNA 34-a regulate SIRT-1 and Foxo-1 expression in endometriosis[J]. Non-coding RNA research,2021,6(1):35-41. doi: 10.1016/j.ncrna.2021.02.002
[11]	Rifaï K,Judes G,Idrissou M,et al. SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer[J]. Oncotarget,2018,9(55):30661-30678. doi: 10.18632/oncotarget.25771
[12]	Wang C,Yang W,Dong F,et al. The prognostic role of Sirt1 expression in solid malignancies:A meta-analysis[J]. Oncotarget,2017,8(39):66343-66351. doi: 10.18632/oncotarget.18494
[13]	Goto T,Haruma K,Kitadai Y,et al. Enhanced expression of inducible nitric oxide synthase and nitrotyrosine in gastric mucosa of gastric cancer patients[J]. Clin Cancer Res,1999,5(6):1411-1415.
[14]	Kornberg M D,Sen N,Hara M R,et al. GAPDH mediates nitrosylation of nuclear proteins[J]. Nat Cell Biol,2010,12(11):1094-1100. doi: 10.1038/ncb2114
[15]	Zhou D,Yang F,Lin L,et al. The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice[J]. Exp Anim,2021,70(3):302-310. doi: 10.1538/expanim.20-0014
[16]	Kiernan R,Brès V,Ng R W,et al. Post-activation turn-off of nf-kappa B-dependent transcription is regulated by acetylation of p65[J]. J Biol Chem,2003,278(4):2758-2766. doi: 10.1074/jbc.M209572200
[17]	Shinozaki S,Chang K,Sakai M,et al. Inflammatory stimuli induce inhibitory s-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65[J]. Sci Signal,2014,7(351):ra106.
[18]	Gregorio D E,Colell A,Morales A,et al. Relevance of SIRT1-nf-κB axis as therapeutic target to ameliorate inflammation in liver disease[J]. Int J Mol Sci,2020,21(11):3858. doi: 10.3390/ijms21113858
[19]	Nopparat C,Sinjanakhom P,Govitrapong P. Melatonin reverses H₂O₂ -induced senescence in SH-SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of nf-κB[J]. J Pineal Res,2017,63(1):e12407. doi: 10.1111/jpi.12407
[20]	Chen Y J,Ching W C,Chen J S,et al. Decoding the s-nitrosoproteomic atlas in individualized human colorectal cancer tissues using a label-free quantitation strategy[J]. J Proteome Res,2014,13(11):4942-4958. doi: 10.1021/pr5002675
[21]	Guslandi M. Nitric oxide in ulcerative colitis[J]. Lancet,1993,341(8849):905-906.
[22]	Miller M J,Sandoval M. Nitric oxide. III. A molecular prelude to intestinal inflammation[J]. Am J Physiol,1999,276(4):G795-G799.
[23]	Zhao Q,Zheng K,Ma C,et al. PTPS facilitates compartmentalized LTBP1 s-nitrosylation and promotes tumor growth under hypoxia[J]. Mol Cell,2020,77(1):95-107. doi: 10.1016/j.molcel.2019.09.018
[24]	Gao Y,Zhou S,Xu Y,et al. Nitric oxide synthase inhibitors 1400W and L-NIO inhibit angiogenesis pathway of colorectal cancer[J]. Nitric oxide,2019,83(2):33-39.
[25]	Li K,Huang M,Xu P,et al. Microcystins-LR induced apoptosis via s-nitrosylation of GAPDH in colorectal cancer cells[J]. Ecotoxicol Environ Saf,2020,190(3):110096.
[26]	Leon-Bollotte L,Subramaniam S,Cauvard O,et al. S-nitrosylation of the death receptor fas promotes fas ligand-mediated apoptosis in cancer cells[J]. Gastroenterology,2011,140(7):2009-2018. doi: 10.1053/j.gastro.2011.02.053
[27]	Zhao J,O'neil M,Schonfeld M,et al. Hepatocellular protein arginine methyltransferase 1 suppresses alcohol-induced hepatocellular carcinoma formation by inhibition of inducible nitric oxide synthase[J]. Hepatol Commun,2020,4(6):790-808. doi: 10.1002/hep4.1488
[28]	López-Sánchez L M,Corrales F J,López-Pedrera C,et al. Pharmacological impairment of s-nitrosoglutathione or thioredoxin reductases augments protein s-nitrosation in human hepatocarcinoma cells[J]. Anticancer Res,2010,30(2):415-421.
[29]	Stomberski C T,Hess D T,Stamler J S. Protein s-nitrosylation:Determinants of specificity and enzymatic regulation of s-nitrosothiol-based signaling[J]. Antioxid Redox Signal,2019,30(10):1331-1351. doi: 10.1089/ars.2017.7403
[30]	Fukumura D,Kashiwagi S,Jain R K. The role of nitric oxide in tumour progression[J]. Nat Rev Cancer,2006,6(7):521-534. doi: 10.1038/nrc1910
[31]	Luanpitpong S,Chanvorachote P. Nitric oxide and aggressive behavior of lung cancer cells[J]. Anticancer Res,2015,35(9):4585-4592.
[32]	Wei W,Li B,Hanes M A,et al. S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis[J]. Sci Transl Med,2010,2(19):19ra3.
[33]	Tang C H,Wei W,Hanes M A,et al. Hepatocarcinogenesis driven by GSNOR deficiency is prevented by iNOS inhibition[J]. Cancer Res,2013,73(9):2897-2904. doi: 10.1158/0008-5472.CAN-12-3980
[34]	González R,Rodríguez-Hernández M A,Negrete M,et al. Downregulation of thioredoxin-1-dependent CD95 s-nitrosation by sorafenib reduces liver cancer[J]. Redox Biol,2020,34(7):101528.
[35]	Wei W,Yang Z,Tang C H,et al. Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine[J]. Carcinogenesis,2011,32(7):973-977. doi: 10.1093/carcin/bgr041
[36]	Kota J,Hancock J,Kwon J,et al. Pancreatic cancer:Stroma and its current and emerging targeted therapies[J]. Cancer Lett,2017,391(4):38-49.
[37]	Tan C,Li Y,Huang X,et al. Extensive protein s-nitrosylation associated with human pancreatic ductal adenocarcinoma pathogenesis[J]. Cell Death Dis,2019,10(12):914. doi: 10.1038/s41419-019-2144-6

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