Epidemiological Situation of Parasitic Diseases in South and Southeast Asian Countries along the “One Belt and One Road”
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摘要: “一带一路”共建国家的八个南亚国家和十一个东南亚国家是寄生虫病的高发区。由于受地理位置、经济状况、文化背景、饮食习惯等诸多原因的影响，疟疾、利士曼原虫、刚地弓形虫、蓝氏贾第鞭毛虫、人芽囊原虫、溶组织内阿米巴、阴道毛滴虫、日本血吸虫、蛔虫、鞭虫、钩虫、粪类圆线虫、蛲虫、带绦虫和丝虫等多种人体寄生虫在该地区流行严重，是一个严峻的公共卫生问题。分析和认识“一带一路”共建国家南亚和东南亚国家寄生虫病的流行状况，有的放矢地制定防控措施，对预防跨境传染病的发生、促进各国之间的密切合作及彻底消除寄生虫病有重要的意义。Abstract: Eight South Asian countries and eleven Southeast Asian countries along the "One Belt and One Road" are areas with high incidences of parasitic diseases. Due to the influence of geographical location, economic status, cultural background, and dietary habits, several human parasites such as Plasmodium spp, Leishmania spp, Toxoplasma gondii, Giardia lamblia, Blastocystis hominis, Entamoeba histolytica, Trichomonas vaginalis, schistosoma japonicum, Ascaris lumbricoides, Trichiruss trichiura, hookworm, strongyloides stercoralis, Enterobius vermicularis, tapeworms, and filaria are prevalent. Parasitic diseases are a serious public health problem in these regions. Analyzing the epidemic situation of parasitic diseases in South and Southeast Asian countries along the "One Belt and One Road", and formulating targeted measures of prevention and control are helpful for preventing the occurrence of cross-border infectious diseases, promoting close cooperation between countries, and completely eliminating parasitic diseases.
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Key words:
- One Belt and One Road /
- Parasitic diseases /
- South Asia /
- Southeast Asia
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表 1 菲律宾农村地区常见寄生虫病患病率（%）
Table 1. Prevalence of common parasitic diseases in rural areas of the Philippines（%）
感染寄生虫种类 患病率 成人 儿童 总体 血吸虫 13.7 11.6 12.5 土源性线虫 64.0 65.1 64.6 蛔虫 27.0 35.1 31.5 鞭虫 50.5 55.1 53.1 钩虫 10.0 2.7 5.9 土源性线虫与血吸虫混合感染 10.5 9.1 9.7 
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表 2 “一带一路”沿线南亚、东南亚国家寄生虫病流行情况（1）
Table 2. The prevalence of parasitic diseases in South and Southeast Asian countries along the “One Belt and One Road” （1）
国家 寄生虫种 年份 风险人数 病例数（例） 患病率 病死率 参考文献 印度 间日疟 2014 0.3% [4] 弓形虫 1991 57％（马翁族人） [21] 巴基斯坦 疟原虫 2012 450万 [5] 皮肤利什曼原虫 2005 738 [27] 孟加拉国 疟原虫 2013 3.1%～36% [8] 阿富汗 疟原虫 2002 12 786 [10] 疟原虫 2015 850万 61 362 [10] 疟原虫 2016 1 009 [10] 尼泊尔 疟疾 1985 42 321 [11] 蓝氏贾第鞭毛虫 2014 8.9% [32] 人芽囊原虫 2014 6.9% [32] 蛔虫 2014 15.6% [32] 鞭虫 2014 1.2% [32] 钩虫 2014 10.4% [32] 带绦虫 2014 3.4% [32] 不丹 疟原虫 2010 436 [12] 印度尼西亚 疟原虫 2007 2.89‰ [15] 弓形虫 2017 50% [24] 阴道毛滴虫 2005 15.1% [33] 日本血吸虫 2019 0.3％～4.8％（纳普、林杜河谷地区） [42] 疟原虫 2017 6500万 0.9‰ [15] 土源性线虫 2008 61％ [42] 丝虫 2014 4.7％ [42] 泰国 疟原虫 2000 2.61% [20] 疟原虫 2016 18 758 0.28% [20] 人芽囊原虫 2017 4.0％ [38] 蓝氏贾第鞭毛虫 2017 0.6% [38] 钩虫 2008 8.0％ [48] 粪类圆线虫 2008 0.9％ [48] 鞭虫 2008 0.3％ [48] 旋毛虫 2008 0.24～3.9/十万 [48] 马来西亚 弓形虫 2011 10%～77％ [21] 结肠内阿米巴 2013 3.2％ [35] 溶组织内阿米巴 2013 1.8％ [35] 蓝氏贾第鞭毛虫 2013 1.8％ [35] 人芽囊原虫 2013 1.2% [35] 鞭虫 2013 20.2％（儿童） [35] 蛔虫 2013 10.5％（儿童） [35] 钩虫 2013 6.7％（儿童） [35] 粪类圆线虫 2019 13.7％（小学生） [46] 猪囊虫 1996 2.2％（农村人口） [58]
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表 2 “一带一路”沿线南亚、东南亚国家寄生虫病流行情况（2）
Table 2. The prevalence of parasitic diseases in South and Southeast Asian countries along the “One Belt and One Road” （2）
国家 寄生虫种 年份 风险人数 病例数（例） 患病率 病死率 参考文献 菲律宾 溶组织内阿米巴 2018 12.1% [36] 蓝氏贾第鞭毛虫 2018 4.5％ [36] 人芽囊原虫 2018 34.4％ [36] 日本血吸虫 2019 670万 74.5％ [41] 越南 弓形虫 2013 1～24％ [26] 蓝氏贾第鞭毛虫 2013 4.1％ [26] 带绦虫 2013 0.2-7.2％ [26] 缅甸 人芽囊原虫 2019 6.29％（中缅边境地区） [37] 鞭虫 2010 13.3% [47] 蛲虫 2010 8.1% [47] 华支睾吸虫 2010 0.7% [47] 丝虫 2018 2.63％ [65] 老挝 钩虫 2018 87％ [49] 鞭虫 2018 33% [49] 粪类圆线虫 2018 45％ [49] 柬埔寨 鞭虫 2018 4.1% [51]
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[1] WHO. World malaria report 2021: Regional data and trends. https://wwwwhoint/publications/m/item/WHO-UCN-GMP-2021092021. [2] Singh V,Mishra N,Awasthi G,et al. Why is it important to study malaria epidemiology in India[J]. Trends Parasitol,2009,25(10):452-427. doi: 10.1016/j.pt.2009.06.004 [3] Kochar D K,Das A,Kochar A,et al. A prospective study on adult patients of severe malaria caused by Plasmodium falciparum,Plasmodium vivax and mixed infection from Bikaner,northwest India[J]. J Vector Borne Dis,2014,51(3):200-210. [4] Rahimi B A,Thakkinstian A,White N J,et al. Severe vivax malaria:a systematic review and meta-analysis of clinical studies since 1900[J]. Malar J,2014,13:481. doi: 10.1186/1475-2875-13-481 [5] Umer M F, Zofeen S, Majeed A, et al. Spatiotemporal Clustering Analysis of Malaria Infection in Pakistan[J]. Int J Environ Res Public Health, 2018, 15（6）: 1202. [6] Yasinzai M I,Kakarsulemankhel J K. Prevalence of human malaria infection in bordering areas of East Balochistan,adjoining with Punjab:Loralai and Musakhel[J]. J Pak Med Assoc,2009,59(3):132-135. [7] Tariq A,Adnan M,Amber R,et al. Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites[J]. Ann Clin Microbiol Antimicrob,2016,15(1):52. doi: 10.1186/s12941-016-0170-0 [8] Islam N,Bonovas S,Nikolopoulos G K. An epidemiological overview of malaria in Bangladesh[J]. Travel Med Infect Dis,2013,11(1):29-36. doi: 10.1016/j.tmaid.2013.01.004 [9] Alam M S,Khan M G,Chaudhury N,et al. Prevalence of anopheline species and their Plasmodium infection status in epidemic-prone border areas of Bangladesh[J]. Malar J,2010,9:15. doi: 10.1186/1475-2875-9-15 [10] Safi N H,Ahmadi A A,Nahzat S,et al. Evidence of metabolic mechanisms playing a role in multiple insecticides resistance in Anopheles stephensi populations from Afghanistan[J]. Malar J,2017,16(1):100. doi: 10.1186/s12936-017-1744-9 [11] Rijal K R,Adhikari B,Ghimire P,et al. Epidemiology of Plasmodium vivax Malaria Infection in Nepal[J]. Am J Trop Med Hyg,2018,99(3):680-687. doi: 10.4269/ajtmh.18-0373 [12] Yangzom T,Gueye C S,Namgay R,et al. Malaria control in Bhutan:case study of a country embarking on elimination[J]. Malar J,2012,11:9. doi: 10.1186/1475-2875-11-9 [13] Grignard L,Shah S,Chua T H,et al. Natural Human Infections With Plasmodium cynomolgi and Other Malaria Species in an Elimination Setting in Sabah,Malaysia[J]. J Infect Dis,2019,220(12):1946-1949. doi: 10.1093/infdis/jiz397 [14] Singh B,Daneshvar C. Plasmodium knowlesi malaria in Malaysia[J]. Med J Malaysia,2010,65(3):166-172. [15] Sitohang V,Sariwati E,Fajariyani S B,et al. Malaria elimination in Indonesia:halfway there[J]. Lancet Glob Health,2018,6(6):e604-e606. doi: 10.1016/S2214-109X(18)30198-0 [16] Xu S, Zeng W, Ngassa Mbenda HG, et al. Efficacy of directly-observed chloroquine-primaquine treatment for uncomplicated acute Plasmodium vivax malaria in northeast Myanmar: A prospective open-label efficacy trial[J]. Travel Med Infect Dis, 2019, 10: 1499. [17] Briand V,Le Hesran J Y,Mayxay M,et al. Prevalence of malaria in pregnancy in southern Laos:a cross-sectional survey[J]. Malar J,2016,15(1):436. doi: 10.1186/s12936-016-1492-2 [18] Thanh P V,Van Hong N,Van Van N,et al. Epidemiology of forest malaria in Central Vietnam:the hidden parasite reservoir[J]. Malar J,2015,14:86. doi: 10.1186/s12936-015-0601-y [19] Bannister-Tyrrell M,Xa N X,Kattenberg J H,et al. Micro-epidemiology of malaria in an elimination setting in Central Vietnam[J]. Malar J,2018,17(1):119. doi: 10.1186/s12936-018-2262-0 [20] Sudathip P,Kongkasuriyachai D,Stelmach R,et al. The Investment Case for Malaria Elimination in Thailand:A Cost-Benefit Analysis[J]. Am J Trop Med Hyg,2019,100(6):1445-1453. doi: 10.4269/ajtmh.18-0897 [21] Singh S,Nautiyal B L. Seroprevalence of toxoplasmosis in Kumaon region of India[J]. Indian J Med Res,1991,93:247-249. [22] Ngui R,Ishak S,Chuen C S,et al. Prevalence and risk factors of intestinal parasitism in rural and remote West Malaysia[J]. PLoS Negl Trop Dis,2011,5(3):e974. doi: 10.1371/journal.pntd.0000974 [23] Ahmad A F,Ngui R,Muhammad Aidil R,et al. Current status of parasitic infections among Pangkor Island community in Peninsular Malaysia[J]. Trop Biomed,2014,31(4):836-843. [24] Tuda J,Adiani S,Ichikawa-Seki M,et al. Seroprevalence of Toxoplasma gondii in humans and pigs in North Sulawesi,Indonesia[J]. Parasitol Int,2017,66(5):615-618. doi: 10.1016/j.parint.2017.04.011 [25] Muflikhah N D,Supargiyono,Artama W T. Seroprevalence and Risk Factor of Toxoplasmosis in Schizophrenia Patients Referred to Grhasia Psychiatric Hospital,Yogyakarta,Indonesia[J]. Afr J Infect Dis,2018,12(1 Suppl):76-82. [26] Carrique-Mas J J,Bryant J E. A review of foodborne bacterial and parasitic zoonoses in Vietnam[J]. Ecohealth,2013,10(4):465-489. doi: 10.1007/s10393-013-0884-9 [27] Khan S J,Muneeb S. Cutaneous leishmaniasis in Pakistan[J]. Dermatol Online J,2005,11(1):4. [28] Aerts C,Vink M,Pashtoon S J,et al. Cost Effectiveness of New Diagnostic Tools for Cutaneous Leishmaniasis in Afghanistan[J]. Appl Health Econ Health Policy,2019,17(2):213-230. doi: 10.1007/s40258-018-0449-8 [29] Thornton S J,Wasan K M,Piecuch A,et al. Barriers to treatment for visceral leishmaniasis in hyperendemic areas:India,Bangladesh,Nepal,Brazil and Sudan[J]. Drug Dev Ind Pharm,2010,36(11):1312-1319. doi: 10.3109/03639041003796648 [30] Singh B B,Sharma R,Sharma J K,et al. Parasitic zoonoses in India:an overview[J]. Rev Sci Tech,2010,29(3):629-637. doi: 10.20506/rst.29.3.2007 [31] Galgamuwa L S,Dharmaratne S D,Iddawela D. Leishmaniasis in Sri Lanka:spatial distribution and seasonal variations from 2009 to 2016[J]. Parasit Vectors,2018,11(1):60. doi: 10.1186/s13071-018-2647-5 [32] Devleesschauwer B,Ale A,Torgerson P,et al. The burden of parasitic zoonoses in Nepal:a systematic review[J]. PLoS Negl Trop Dis,2014,8(1):e2634. doi: 10.1371/journal.pntd.0002634 [33] Mawu F O,Davies S C,McKechnie M,et al. Sexually transmissible infections among female sex workers in Manado,Indonesia,using a multiplex polymerase chain reaction-based reverse line blot assay[J]. Sex Health,2011,8(1):52-60. doi: 10.1071/SH10023 [34] Tanudyaya F K,Rahardjo E,Bollen L J,et al. Prevalence of sexually transmitted infections and sexual risk behavior among female sex workers in nine provinces in Indonesia,2005[J]. Southeast Asian J Trop Med Public Health,2010,41(2):463-473. [35] Sinniah B,Hassan A K,Sabaridah I,et al. Prevalence of intestinal parasitic infections among communities living in different habitats and its comparison with one hundred and one studies conducted over the past 42 years (1970 to 2013) in Malaysia[J]. Trop Biomed,2014,31(2):190-206. [36] Weerakoon K G,Gordon C A,Williams G M,et al. Co-parasitism of intestinal protozoa and Schistosoma japonicum in a rural community in the Philippines[J]. Infect Dis Poverty,2018,7(1):121. doi: 10.1186/s40249-018-0504-6 [37] Gong B,Liu X,Wu Y,et al. Prevalence and subtype distribution of Blastocystis in ethnic minority groups on both sides of the China-Myanmar border,and assessment of risk factors[J]. Parasite,2019,26:46. doi: 10.1051/parasite/2019046 [38] Punsawad C,Phasuk N,Bunratsami S,et al. Prevalence of intestinal parasitic infection and associated risk factors among village health volunteers in rural communities of southern Thailand[J]. BMC Public Health,2017,17(1):564. doi: 10.1186/s12889-017-4486-2 [39] Kang G,Mathew M S,Rajan D P,et al. Prevalence of intestinal parasites in rural Southern Indians[J]. Trop Med Int Health,1998,3(1):70-75. doi: 10.1046/j.1365-3156.1998.00175.x [40] Traub R J,Robertson I D,Irwin P,et al. Thompson RC. Humans,dogs and parasitic zoonoses--unravelling the relationships in a remote endemic community in northeast India using molecular tools[J]. Parasitol Res,2003,90(Suppl 3):S156-S157. [41] Francisco I,Jiz M,Rosenbaum M,et al. Knowledge,attitudes and practices related to schistosomiasis transmission and control in Leyte,Philippines[J]. PLoS Negl Trop Dis,2019,13(5):e0007358. doi: 10.1371/journal.pntd.0007358 [42] Lee J,Ryu JS. Current Status of Parasite Infections in Indonesia:A Literature Review[J]. Korean J Parasitol,2019,57(4):329-339. doi: 10.3347/kjp.2019.57.4.329 [43] Karthikeyan K,Thappa D M,Jeevankumar B. Cutaneous larva migrans of the penis[J]. Sex Transm Infect,2003,79(6):500. doi: 10.1136/sti.79.6.500 [44] Krsak M,Patel N U,Poeschla E M. Case Report:Hepatic Fascioliasis in a Young Afghani Woman with Severe Wheezing,High-Grade Peripheral Eosinophilia,and Liver Lesions:A Brief Literature Review[J]. Am J Trop Med Hyg,2019,100(3):588-590. doi: 10.4269/ajtmh.18-0625 [45] Liwanag H J,Uy J,Bataller R,et al. Soil-Transmitted Helminthiasis and Schistosomiasis in Children of Poor Families in Leyte,Philippines:Lessons for Disease Prevention and Control[J]. J Trop Pediatr,2017,63(5):335-345. [46] Al-Mekhlafi H M,Nasr N A,Lim Y A L,et al. Prevalence and risk factors of Strongyloides stercoralis infection among Orang Asli schoolchildren:new insights into the epidemiology,transmission and diagnosis of strongyloidiasis in Malaysia[J]. Parasitology,2019,146(12):1602-14. doi: 10.1017/S0031182019000945 [47] Hotez P J,Ehrenberg J P. Escalating the global fight against neglected tropical diseases through interventions in the Asia Pacific region[J]. Adv Parasitol,2010,72:31-53. [48] Kaewpitoon N,Kaewpitoon S J,Pengsaa P. Food-borne parasitic zoonosis:distribution of trichinosis in Thailand[J]. World J Gastroenterol,2008,14(22):3471-3475. doi: 10.3748/wjg.14.3471 [49] Htun N S N,Odermatt P,Paboriboune P,et al. Association between helminth infections and diabetes mellitus in adults from the Lao People's Democratic Republic:a cross-sectional study[J]. Infect Dis Poverty,2018,7(1):105. doi: 10.1186/s40249-018-0488-2 [50] Liao C W,Chiu K C,Chiang I C,et al. Prevalence and Risk Factors for Intestinal Parasitic Infection in Schoolchildren in Battambang,Cambodia[J]. Am J Trop Med Hyg,2017,96(3):583-588. [51] Phosuk I,Sanpool O,Thanchomnang T,et al. Molecular Identification of Trichuris suis and Trichuris trichiura Eggs in Human Populations from Thailand,Lao PDR,and Myanmar[J]. Am J Trop Med Hyg,2018,98(1):39-44. doi: 10.4269/ajtmh.17-0651 [52] Khieu V,Furst T,Miyamoto K,et al. Is Opisthorchis viverrini Emerging in Cambodia?[J]. Adv Parasitol,2019,103:31-73. [53] Ng-Nguyen D,Stevenson M A,Traub R J. A systematic review of taeniasis,cysticercosis and trichinellosis in Vietnam[J]. Parasit Vectors,2017,10(1):150. doi: 10.1186/s13071-017-2085-9 [54] Aung A K,Spelman D W. Taenia solium Taeniasis and Cysticercosis in Southeast Asia[J]. Am J Trop Med Hyg,2016,94(5):947-954. doi: 10.4269/ajtmh.15-0684 [55] Prasad K N,Chawla S,Jain D,et al. Human and porcine Taenia solium infection in rural north India[J]. Trans R Soc Trop Med Hyg,2002,96(5):515-516. doi: 10.1016/S0035-9203(02)90423-2 [56] Foo S S,Selvan V S,Clarke M J,et al. Unusual cause of seizures in Singapore:neurocysticercosis[J]. Singapore Med J,2008,49(6):e147-150. [57] Xu J M,Acosta L P,Hou M,et al. Seroprevalence of cysticercosis in children and young adults living in a helminth endemic community in leyte,the Philippines[J]. J Trop Med,2010,2010:603174. [58] Noor Azian M Y,Hakim S L,Sumiati A,et al. Seroprevalence of cysticercosis in a rural village of Ranau,Sabah,Malaysia[J]. Southeast Asian J Trop Med Public Health,2006,37(1):58-61. [59] Wandra T,Ito A,Swastika K,et al. Taeniases and cysticercosis in Indonesia:past and present situations[J]. Parasitology,2013,140(13):1608-1616. doi: 10.1017/S0031182013000863 [60] Zein U,Siregar S,Janis I,et al. Identification of a previously unidentified endemic region for taeniasis in North Sumatra,Indonesia[J]. Acta Trop,2019,189:114-116. doi: 10.1016/j.actatropica.2018.10.004 [61] Salim L,Ang A,Handali S,et al. Seroepidemiologic survey of cysticercosis-taeniasis in four central highland districts of Papua,Indonesia[J]. Am J Trop Med Hyg,2009,80(3):384-388. doi: 10.4269/ajtmh.2009.80.384 [62] McCleery E J,Patchanee P,Pongsopawijit P,et al. Taeniasis among Refugees Living on Thailand-Myanmar Border,2012[J]. Emerg Infect Dis,2015,21(10):1824-1826. [63] Anantaphruti M T,Okamoto M,Yoonuan T,et al. Molecular and serological survey on taeniasis and cysticercosis in Kanchanaburi Province,Thailand[J]. Parasitol Int,2010,59(3):326-330. doi: 10.1016/j.parint.2010.03.007 [64] Sato M O,Sato M,Yanagida T,et al. Taenia solium,Taenia saginata,Taenia asiatica,their hybrids and other helminthic infections occurring in a neglected tropical diseases' highly endemic area in Lao PDR[J]. PLoS Negl Trop Dis,2018,12(2):e0006260. doi: 10.1371/journal.pntd.0006260 [65] Dickson B F R,Graves P M,Aye N N,et al. The prevalence of lymphatic filariasis infection and disease following six rounds of mass drug administration in Mandalay Region,Myanmar[J]. PLoS Negl Trop Dis,2018,12(11):e0006944. doi: 10.1371/journal.pntd.0006944 -
